Gastrointestinal Stromal Tümörlerin Demografik, Histopatolojik, ve İmmünohistokimyasal Karakteristik Bulguları: Tek Merkez Çalışması

Year 2020, Volume: 10 Issue: 3, 381 - 389, 15.09.2020

Arzu Tasdemir , Hatice Karaman

https://doi.org/10.31832/smj.740190

Abstract

Amaç: Gastrointestinal
stromal tümör (GİST), gastrointestinal sistemin en sık görülen mezenkimal
tümörüdür, interstisyel Cajal hücresinden kaynaklanır veya farklılaşır. Bu
çalışmanın amacı GIST tanılı olguların demografik, histopatolojik ve
immünohistokimyasal özelliklerini literatür ışığında gözden geçirmektir.

Gereç ve Yöntemler:
Çalışmayaxxxxxx Şehir hastanesi patoloji kliniğinde, 2010-2018 yılları arasında
tanı konulan 45 GİST olgusu dahil edildi. Olgular retrospektif olarak
hematoksilen-eozin kesitleri ve immünohistokimyasal boyamaları ile yeniden
değerlendirildi.

Bulgular: Olguların 21'i (%46,66) kadın, 24'ü
(%53,33) erkekti. Yaş ortalaması 64.9 idi. Çalışmaya dahil edilen olguların
4/45'i(%8,88) çok düşük, 20/45'i (%44,44) düşük, 8/45'i (%17,77) orta
derecedeydi ve 13 / 45 olgu (%28.88) yüksek risk grubundaydı.

Sonuç:
GİST'lerde doğru tanı, sınıflandırma, prognoz ve tedavi için histopatoloji ve
immünhistokimyasal çalışmalar önemlidir. Merkezler, rapor formatlarını
uluslararası kabul görmüş rapor örneklerine ve fikir birliği kriterlerine göre
hazırlamalı ve özel makroskobik ve mikroskobik bulgular ile immünohistokimyasal
inceleme sonuçları raporun sonunda liste halinde verilmelidir.

Keywords

gastroi̇ntesti̇nal stromal tümörler, histopatoloji, immunohistokimyasal boyama

Supporting Institution

Kayseri Şehir Hastanesi

Demographic, Histopathological and Immunohistochemical Characteristic Findings of Gastrointestinal Stromal Tumors: A Single-Centered Study

Abstract

Objective:
Gastrointestinal stromal tumor (GIST) is the most frequent mesenchymal tumor of
the gastrointestinal tract, arises from or is differentiated towards
interstitial cell of Cajal. The aim of this study is to review the demographic,
histopathological and immunohistochemical characteristics of cases diagnosed
with GIST in the light of the literature.

Material and Methods: 

Forty-five GIST cases diagnosed between 2010 and 2018 in xxxxxx
City Hospital's pathology clinic were included in the study. The
cases were reevaluated retrospectively by hematoxylin-eosin sections and
immunohistochemical staining.

Results: Twenty-one of the cases (46.66%) were
female, and 24 (53.33%) were male. The average age was 64.9 years. 4/45 (8.88%)
of the cases included in the study were in the very low risk, 20/45 (44.44%)
were in the low risk, 8/45 (17.77%) were in the intermediate risk, and 13/45
cases (28.88%) were in the high-risk group.

Conclusion:
Histopathology and immunohistochemical studies are important for the accurate
diagnosis, classification, prognosis, and treatment in GISTs. The centers
should prepare their report formats according to internationally accepted
report samples and consensus criteria, and significant macroscopic and
microscopic findings and immunohistochemical examination results should be
given as a list at the end of the report.

Keywords

Gastrointestinal stromal tumors, histopathology, immunohistochemistry staining

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