Spinal Herniasyon Hastalarının Toplam Antioksidan Seviyeleri

Year 2020, Volume: 10 Issue: 3, 445 - 449, 15.09.2020

Halil İbrahim Sun

https://doi.org/10.31832/smj.747736

Abstract

Amaç: İnflamatuar yanıt disk bozulmalarında görülen önemli bir faktör olarak kabul görmüştür ve spinal herniasyon hastalarında acı hissinin ortaya çıkmasında önemli bir rolü olabilir. Bu çalışmanın amacı, cerrahi tedavi görmüş spinal herniasyon hastalarındaki toplam antioksidan statüsü (TAS), toplam oksidan statüsü (TOS) ve oranlanmalarından ortaya çıkan oksidatif stress endeksinin (OSE) ölçülmesi ve bu değerlerin toplanan yaş, cinsiyet ve herniasyon bölgesi arasında ilişki olup olmadığının araştırılmasıdır.

Gereç ve Yöntemler: 19 kadın (48,72%) ve 20 erkek (51,28%) hasta çalışmaya dahil edilmiştir. TAS ve TOS seviyeleri laboratuvarda bulunan kitlerle ölçülmüş ve OSE bu değerlerin oranlanmasıyla elde edilmiştir (Rel Assay Diagnostics, Türkiye).

Bulgular: Sonuçlar spinal herniasyonlu hastalarda ortalama TAS seviyesinin,1.518 ± 0.176, ortalama TOS seviyesinin 3.168 ± 0.956, ve ortalama OSE değerinin 0.222 ± 0.078 olduğunu %95 güven aralığıyla göstermektedir. Demografik ve herniasyon bölgesi değişkenlerinin TAS, TOS ve OSE değerleri üzerinde bir etkisi bulunamamıştır.

Sonuç: Cerrahi tedavi görmüş spinal herniasyon hastalarının normal oksidatif durumda oldukları ve diğer değişkenlerin bu bulgu üstünde etkisi yoktur.

Keywords

Spinal herniasyon, antioksidan, serbest radikal, oksidatif stres

Total Antioxidant Levels in Patients with Spinal Herniation

Abstract

Objective: Inflammatory response has been acknowledged to be an important factor in the process of disc degeneration and may play an important role in generation of pain, among patients with spinal herniation. The aim of this study is to investigate the total antioxidant status (TAS), total oxidant status (TOS), and their ratio, oxidative stress index (OSI) in patients with spinal herniations, and the relationship between these dependent variables and location of herniation, gender and age.

Materials and Methods: 19 female (48,72%) and 20 male (51,28%) patients are included in the study. TAS and TOS levels are measured by commercially available kits in laboratory (Rel Assay Diagnostics, Turkey). OSI levels are calculated by their ratio.

Results: Results show that mean TAS level is 1.518 ± 0.176, mean TOS level is 3.168 ± 0.956, and mean OSI level is 0.222 ± 0.078 with 95 % confidence interval. No correlations are found between age with the TAS, TOS and OSI levels.

Conclusion: Post-operative patients with spinal herniation have normal oxidative statuses and the location of herniation and gender seems to have no effect on the TAS, TOS and OSI levels.

Keywords

spinal herniation, antioxidant, free radical, oxidative stress

References

• Kim YK, Kang D, Lee I, & Kim SY. Differences in the Incidence of Symptomatic Cervical and Lumbar Disc Herniation According to Age, Sex and National Health Insurance Eligibility: A Pilot Study on the Disease’s Association with Work. International journal of environmental research and public health 2018;15(10):2094.
• Cunha C, Silva A, Pereira P, Vaz R, Gonçalves R, Barbosa M. The inflammatory response in the regression of lumbar disc herniation. Arthritis Res Ther 2018;20(1):251.
• Muramatsu K, Hachiya Y, Morita C. Postoperative magnetic resonance imaging of lumbar disc herniation: comparison of microendoscopic discectomy and Love's method. Spine 2001;26:1599–1605.
• Liuke M, Solovieva S, Lamminen A et al. Disc degeneration of the lumbar spine in relation to overweight. Int J Obes 2005;29(8):903-908.
• Dario AB, Ferreira ML, Refshauge KM, Lima TS, Ordoñana JR, Ferreira PH. The relationship between obesity, low back pain, and lumbar disc degeneration when genetics and the environment are considered: A systematic review of twin studies Spine J 2015;15:1106–1117.
• Takatalo J, Karppinen J, Taimela S et al. Association of Abdominal Obesity with Lumbar Disc Degeneration – A Magnetic Resonance Imaging Study. PLoS ONE 2013;8(2):e56244.
• Goupille P, Jayson M, Valat J, Freemont A. The role of inflammation in disk herniation-associated radiculopathy. Semin Arthritis Rheum 1998;28(1):60-71.
• Yang X, Jin L, Yao L, Shen FH, Shimer AL, Li X. Antioxidative nanofullerol prevents intervertebral disk degeneration. Int J Nanomedicine 2014;15(9):2419-2430.
• Xiao L, Ding M, Fernandez A, Zhao P, Jin L, Li X. Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors. European Cells and Materials 2017;33:279-293.
• Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 2010;4(8):118.
• Alberto Alexandre E, Andrea Alexandre E. Disc Herniation and Knee Arthritis as Chronic Oxidative Stress Diseases: The Therapeutic Role of Oxygen Ozone Therapy. J Arthritis 2015;04(03).
• Ray P, Huang B, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal 2012;24(5):981-990.
• Sies H. Oxidative stress: oxidants and antioxidants. Exp Physiol 1997;82(2):291-295.
• Katerji M, Filippova M, Duerksen-Hughes P. Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field. Oxid Med Cell Longev 2019;2019:1-29.
• Sharma R, Pasqualotto F, Nelson D, Thomas A, Agarwal A. The reactive oxygen species—total antioxidant capacity score is a new measure of oxidative stress to predict male infertility*. Human Reproduction 1999;14(11):2801-2807.
• Zhou L, Feng JT, Zhang L, Kuang Y. Clinical significance of serum total oxidant/antioxidant status for the disease activity in active rheumatoid arthritis. International Journal of Clinical and Experimental Pathology 2017;10.8: 8895-8900.
• Buico A, Cassino C, Ravera M, Betta P, Osella D. Oxidative stress and total antioxidant capacity in human plasma. Redox Report 2009;14(3):125-131.
• Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radicalcation. Clin Biochem 2004;37:277-85.
• Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38:1103-11.