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Analysis of Hematological Parameters According to TSH Levels in Thyroid Patients

Year 2023, Volume: 13 Issue: 2, 247 - 254, 30.06.2023
https://doi.org/10.31832/smj.1019576

Abstract

Objective: In this study, it was aimed to investigate hematological parameters according to thyroid stimulating hormone (TSH) levels in thyroid patients.
Materials and Methods: Thyroid function tests and hemogram data of 5130 thyroid patients admitted to our hospital between January 2019 and August 2021 were analyzed retrospectively.
Results: There was no significant difference between hemoglobin, MCH, leukocyte, basophil and thrombocyte levels according to TSH levels. When compared in terms of MCV, a significant difference was found between group 1 (TSH<0.05) and group 2 (TSH=0.5-4.99) (p<0.001) and group 2 (TSH=0.5-4.99) and group 4 (TSH ≥10). When the neutrophil levels were compared, there were significant differences between group 1 and group 2, group 3 (TSH=5.0-9.99) and group 4. When the lymphocyte levels were compared, there were significant differences between group 1 and group 2 and group 3, and between group 2 and group 3. When monocyte and eosinophil levels were compared, there were significant differences between group 1 and group 4, group 2 and group 3. there were differences. When MPV levels were compared, there were significant differences between group 1 and group 4, and between group 2 and group 3. There were significant differences between the 3rd and 4th groups in terms of MPV levels.
Conclusions: It was determined that there was a significant difference between MCV, neutrophil, lymphocyte, monocytes, eosinophil and MCV values.

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References

  • 1. Tiroid Hastalıklarına Güncel Yaklaşım. Metin Özata, 1. Baskı, Epsilon Yayınları, 2005, İstanbul.
  • 2. Tiroid El Kitabı. Prof. Dr. Taylan Kabalak. 1. Basım, Güven Kitabevi, 2009, İzmir.
  • 3. Harrison Endokrinoloji. J Larry Jameson, Çeviri Editörü Abdullah Bereket, Nobel Tıp Kitabevi, 2009, Ankara.
  • 4. Kaya Z. Interpretation of automated blood cell counts. Dicle Medical Journal. 2013; 40 (3): 521-528.
  • DOI:10.5798/diclemedj.0921.2013.03.0326 5. Sağlam F, Çakır B. Clinical Approach To Thyroid Diseases In Primary Health Care. Ankara Medical Journal, 2012; 12(3): 136-139.
  • 6. Volkan Sinan. Hipotiroidili ve hipertiroidili hastalarda HbA1c düzeyi. Uzmanlık Tezi. İstanbul 2006.
  • 7. Emirzeoğlu M, Sancak R. Tiroit bezi anatomisi, Journal of Experimental and Clinical Medicine, 2012; 29(4S): 273-275. DOI: 10.5835/jecm.omu.29.s4.013
  • 8. Slatosky J, Shipton B, Wahba H, Thyroiditis: differential diagnosisand management. Am. Fam. Physician. 2000;61:1047-1052.
  • 9. Çorapoğlu D, Uysal AR, Çetinarslan B. Haşhimoto tiroiditli olgularımızın klinik ve laboratuvar değerlendirilmesi. Ankara Üniversitesi Tıp Fakültesi mecmuası cilt 49, sayı 1,33-37, 1996.
  • 10. Ferrucci L and Balducci L. “Anemia of aging: the role of chronic inflammation and cancer”. Seminars in Hematology 45.4 (2008): 242-249
  • 11. Çelik B. Tiroid Hormon Disfonksiyonu Olan Hastalarda Trombosit Agregasyon Bozukluğunun İn Vitro Olarak ASPİ/ADP Testleri ile Değerlendirilmesi. Uzmanlık Tezi. Ankara-2014
  • 12. Anand R. “A study of prevalence and pattern of anemia in primary hypothyroidism”. International Journal of Medical Science and Public Health 7.2 (2018):153-160. DOI: 10.5455/ijmsph.2018.1131728122017
  • 13. Szczepanek-Parulska E. “Anemia in thyroid diseases”. Polish Archives of Internal Medicine 127.5(2017): 352-360.
  • 14. Patel RP and Jain A. “Study of anemia in primary hypothyroidism”. Thyroid Research and Practice 14.1(2017):22. DOI: 10.4103/0973-0354.200564
  • 15. Allen Dawson M and W Yarbro J. “Anemia in Hypothyroidism”. Southern Medical Journal 63.8 (1970): 966-970. DOI: 10.1097/00007611-197008000-00018
  • 16. Refaat B. “Prevalence and characteristics of anemia associated with thyroid disorders in non-pregnant Saudi women during the childbearing age: A cross-sectional study”. Biomedical Journal 38.4 (2015): 307-316. DOI: 10.4103/2319-4170.151032.
  • 17. Pekgör S, Eryılmaz MA, Kaya İFK. Evaluation of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Mean Platelet Volume in Patients with Hypothyroidism. Euras J Fam Med 2020;9(3):139-46. DOI: 10.33880/ejfm.2020090304
  • 18. Peraka SA, Karre S, Ravuri S, Shanmugam CK. To evaluate prevalence of anemia in hypothyroid patients. IP J Diagn Pathol Oncol 2019; 4(2): 110-113. DOI: 10.18231/j.jdpo.2019.021
  • 19. Özdin M. Atopik Dermatiti Olan Çocuklarda Hematolojik ve Alerjik Değerler Arasındaki İlişki, Balıkesir Medical Journal, 2020; 4(3): 1-6. DOI: 10.33716/bmedj.760653
  • 20. Bilge M, Adas M, Helvaci A. Neutrophil/LymphocyteRatio (NLR) and Platelet/LymphocyteRatio (PLR) in Patients with Hashimoto's Thyroiditis and Their Relationship with Thyroid Autoimmunity. Endocrine Society 2015 https://endo.confex.com/endo/ 2015endo/webprogram/Paper20422.html
  • 21. Kutluturk F, Gul SS, Sahin S, Tasliyurt T. Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma. Endocr Metab Immune Disord Drug Targets 2019; 19: 859-65.DOI: 10.2174/1871530319666190206125545.

Tiroid Hastalarında TSH Düzeylerine Göre Hematolojik Parametrelerin Analizi

Year 2023, Volume: 13 Issue: 2, 247 - 254, 30.06.2023
https://doi.org/10.31832/smj.1019576

Abstract

Amaç: Bu çalışmada tiroid hastalarında tiroid uyarıcı hormon (TSH) düzeylerine göre hematolojik parametrelerin araştırılması amaçlandı.
Gereç ve Yöntemler: Ocak 2019-Ağustos 2021 tarihleri arasında hastanemize başvuran 5130 tiroid hastasının tiroid fonksiyon testleri ve hemogram verileri retrospektif olarak incelendi.
Bulgular: TSH düzeylerine göre hemoglobin, MCH, lökosit, bazofil ve trombosit düzeyleri arasında anlamlı fark yoktu. MCV açısından karşılaştırıldığında, grup 1 (TSH<0.05) ve grup 2 (TSH=0.5-4.99) (p<0.001) ve grup 2 (TSH=0.5-4.99) ve grup 4 (TSH) arasında anlamlı fark bulundu (TSH ≥10). Nötrofil düzeyleri açısından karşılaştırıldığında grup 1 ve grup 2, grup 3 (TSH=5.0-9.99) ile grup 4 ve grup arasında anlamlı farklar vardı. Lenfosit düzeyleri açısından karşılaştırıldığında, grup 1 ile grup 2 arasında, grup 2 ile grup 3 arasında ve grup 1 ile grup 3 ve grup arasında anlamlı farklar vardı. Monosit ve eozinofil düzeyleri karşılaştırıldığında grup 1 ile grup 4, grup 2 ile grup 3 arasında anlamlı farklar vardı. MPV düzeyleri karşılaştırıldığında grup 1 ile grup 4 arasında, grup 2 ile grup 3 arasında anlamlı farklar vardı. MPV seviyeleri açısından 3. ve 4. grup arasında anlamlı farklar vardı.

Sonuç: MCV, nötrofil, lenfosit, monosit, eozinofil ve MCV değerleri arasında anlamlı fark olduğu belirlendi.

Project Number

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References

  • 1. Tiroid Hastalıklarına Güncel Yaklaşım. Metin Özata, 1. Baskı, Epsilon Yayınları, 2005, İstanbul.
  • 2. Tiroid El Kitabı. Prof. Dr. Taylan Kabalak. 1. Basım, Güven Kitabevi, 2009, İzmir.
  • 3. Harrison Endokrinoloji. J Larry Jameson, Çeviri Editörü Abdullah Bereket, Nobel Tıp Kitabevi, 2009, Ankara.
  • 4. Kaya Z. Interpretation of automated blood cell counts. Dicle Medical Journal. 2013; 40 (3): 521-528.
  • DOI:10.5798/diclemedj.0921.2013.03.0326 5. Sağlam F, Çakır B. Clinical Approach To Thyroid Diseases In Primary Health Care. Ankara Medical Journal, 2012; 12(3): 136-139.
  • 6. Volkan Sinan. Hipotiroidili ve hipertiroidili hastalarda HbA1c düzeyi. Uzmanlık Tezi. İstanbul 2006.
  • 7. Emirzeoğlu M, Sancak R. Tiroit bezi anatomisi, Journal of Experimental and Clinical Medicine, 2012; 29(4S): 273-275. DOI: 10.5835/jecm.omu.29.s4.013
  • 8. Slatosky J, Shipton B, Wahba H, Thyroiditis: differential diagnosisand management. Am. Fam. Physician. 2000;61:1047-1052.
  • 9. Çorapoğlu D, Uysal AR, Çetinarslan B. Haşhimoto tiroiditli olgularımızın klinik ve laboratuvar değerlendirilmesi. Ankara Üniversitesi Tıp Fakültesi mecmuası cilt 49, sayı 1,33-37, 1996.
  • 10. Ferrucci L and Balducci L. “Anemia of aging: the role of chronic inflammation and cancer”. Seminars in Hematology 45.4 (2008): 242-249
  • 11. Çelik B. Tiroid Hormon Disfonksiyonu Olan Hastalarda Trombosit Agregasyon Bozukluğunun İn Vitro Olarak ASPİ/ADP Testleri ile Değerlendirilmesi. Uzmanlık Tezi. Ankara-2014
  • 12. Anand R. “A study of prevalence and pattern of anemia in primary hypothyroidism”. International Journal of Medical Science and Public Health 7.2 (2018):153-160. DOI: 10.5455/ijmsph.2018.1131728122017
  • 13. Szczepanek-Parulska E. “Anemia in thyroid diseases”. Polish Archives of Internal Medicine 127.5(2017): 352-360.
  • 14. Patel RP and Jain A. “Study of anemia in primary hypothyroidism”. Thyroid Research and Practice 14.1(2017):22. DOI: 10.4103/0973-0354.200564
  • 15. Allen Dawson M and W Yarbro J. “Anemia in Hypothyroidism”. Southern Medical Journal 63.8 (1970): 966-970. DOI: 10.1097/00007611-197008000-00018
  • 16. Refaat B. “Prevalence and characteristics of anemia associated with thyroid disorders in non-pregnant Saudi women during the childbearing age: A cross-sectional study”. Biomedical Journal 38.4 (2015): 307-316. DOI: 10.4103/2319-4170.151032.
  • 17. Pekgör S, Eryılmaz MA, Kaya İFK. Evaluation of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Mean Platelet Volume in Patients with Hypothyroidism. Euras J Fam Med 2020;9(3):139-46. DOI: 10.33880/ejfm.2020090304
  • 18. Peraka SA, Karre S, Ravuri S, Shanmugam CK. To evaluate prevalence of anemia in hypothyroid patients. IP J Diagn Pathol Oncol 2019; 4(2): 110-113. DOI: 10.18231/j.jdpo.2019.021
  • 19. Özdin M. Atopik Dermatiti Olan Çocuklarda Hematolojik ve Alerjik Değerler Arasındaki İlişki, Balıkesir Medical Journal, 2020; 4(3): 1-6. DOI: 10.33716/bmedj.760653
  • 20. Bilge M, Adas M, Helvaci A. Neutrophil/LymphocyteRatio (NLR) and Platelet/LymphocyteRatio (PLR) in Patients with Hashimoto's Thyroiditis and Their Relationship with Thyroid Autoimmunity. Endocrine Society 2015 https://endo.confex.com/endo/ 2015endo/webprogram/Paper20422.html
  • 21. Kutluturk F, Gul SS, Sahin S, Tasliyurt T. Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma. Endocr Metab Immune Disord Drug Targets 2019; 19: 859-65.DOI: 10.2174/1871530319666190206125545.
There are 21 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Mehmet Özdin 0000-0003-3077-7171

Selcuk Yaylacı 0000-0002-6768-7973

Taner Demirci 0000-0002-9579-4530

Project Number -
Early Pub Date June 27, 2023
Publication Date June 30, 2023
Submission Date November 5, 2021
Published in Issue Year 2023 Volume: 13 Issue: 2

Cite

AMA Özdin M, Yaylacı S, Demirci T. Analysis of Hematological Parameters According to TSH Levels in Thyroid Patients. Sakarya Tıp Dergisi. June 2023;13(2):247-254. doi:10.31832/smj.1019576

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