Abstract
AMAÇ
Psoriatik Artritte nöropatik ağrı varlığı ile ilişkili klinik ve laboratuvar parametreleri arasındaki ilişki iyi bilinmemektedir ve yeterince çalışılmamıştır. Bu varsayımlara dayanarak çalışmamızın amacı, Psoriatik Artrit hastalığı bulunan kişilerde nöropatik ağrı dediğimiz durumun ne sıklıkta olduğunu ve hastalığın klinik ve laboratuvar parametreleri ile ne kadar ilişkili olduğunu araştırmaktır.
MATERYAL VE METOD
Kesitsel çalışmada The Classification Criteria for Psoriatics'e göre tanı almış 45 Psöriatik Artrit hastası dahil edilmiştir. Çalışmamızda nöropatik ağrı özelliklerinin değerlendirilmesi için Pain Detect Anketi (PDQ) kullanıldı. Objektif ölçümler yapılması amacıyla SPARCC (Spondyloarthritis Research Consortium of Canada) aracılığıyla entezit varlığı belirlendi. Fonkiyonel durum, Sağlık Değerlendirme Anketi (HAQ) ile değerlendirilmiştir. Yaşam kalitesini değerlendirmek için Kısa Form-36 (SF-36) anketi kullanılmıştır.
BULGULAR
Çalışmaya toplam 45 hasta (32 kadın [%71,1], 13 erkek [%28,9]) alınmıştır. Ortalama semptom süresi 78,91 ± 95,8 aydır. Nsaid tedavisi alan 16 hasta (%35,6), DMARD tedavisi alan 28 hasta (%62,2), Biyolojik tedavi alan 13 hasta (%28,9) bulunmaktadır. Çalışmaya alınan hastalarda Pain Detect anketine göre NP olan 30 hasta (%66,7), Nöropatik ağrı olmayan 15 (33,3) saptanmıştır. Bu iki grup arasında DAPSA, VAS hareket, HAQ, sabah tutukluğu ve SF-36 Vücut ağrısı sonuçlarında anlamlı farklılık saptanmıştır.
SONUÇ
Psoriatik Artritli hastalarda Nöropatik ağrının yüksek prevelansta bulunduğu çalışmamızla gösterilmiştir. Bu birlikteliğin fonksiyonel kısıtlılıkla ilişkili olduğu görülmüştür. Ayrıca Ağrı hissi nedeniyle DAPSA skoru Nöropatik ağrı olan hastalarda anlamlı olarak yüksek bulunmuş ve bu da tedavi başarısını düşüren bir etken olabileceğini düşündürmektedir. Nöropatik ağrının tanınması ve tedavi edilmesinin Psoriatik Artrit tedavisindeki başarıyı arttırabileceği düşünülebilir.
References
- 1. Felquer MA, FitzGerald O. Peripheral joint involvement in psoriatic arthritis patients. Clin Exp Rheumatol. 2015;33(93):S26-S30. 2. Kavanaugh A, Helliwell P, Ritchlin CT. Psoriatic arthritis and burden of disease: patient perspectives from the population-based multinational assessment of psoriasis and psoriatic arthritis (MAPP) survey. Rheumatology and therapy. 2016;3(1):91-102. 3. Mease PJ, Gladman DD, Papp KA, et al. Prevalence of rheumatologist-diagnosed psoriatic arthritis in patients with psoriasis in European/North American dermatology clinics. Journal of the American Academy of Dermatology. 2013;69(5):729-735. 4. Kemal N, Kilic E, Cevik R, et al. Management of psoriatic arthritis: Turkish League Against Rheumatism (TLAR) expert opinions. Archives of rheumatology. 2018;33(2):108.
Abstract
Objectives
The relationship between clinical and laboratory parameters associated with the neuropathic pain presence in Psoriatic Arthritis is not well known and has not been adequately studied. Based on these assumptions, the aim of our study is to investigate how often neuropathic pain occurs in Psoriatic Arthritis patients and how much it is related to the clinical and laboratory parameters of the disease.
Methods
In the cross-sectional study, 45 Psoriatic Arthritis patients diagnosed according to The Classification Criteria for Psoriatics were included. In our study, Pain Detect Questionnaire (PDQ) was used to assess the neuropathic pain characteristics. Presence of enthesitis was determined by SPARCC to ensure objective measurements. Functional status was evaluated with the Health Assessment Questionnaire (HAQ). The Short Form-36 (SF-36) questionnaire was used to evaluate the quality of life.
Results
A total of 45 patients were included in the study. The mean duration of symptoms was 78.91 ± 95.8 months. There are 16 patients receiving Nsaid treatment, 28 patients receiving DMARD treatment, and 13 patients receiving biological therapy. Among the patients included in the study, 30 patients with neuropathic pain and 15 without neuropathic pain were found according to the Pain Detect questionnaire. A significant difference was observed between these two groups in the results of DAPSA, VAS movement, HAQ, morning stiffness, and SF-36 Body pain.
Conclusion
Our study has shown that neuropathic pain has a high prevalence in Psoriatic Arthritis patients. This association was observed to be related to functional limitation. Additionally, the DAPSA score was found to be significantly higher in patients with neuropathic pain due to pain sensation which suggests that it may be a factor reducing treatment success. It is conceivable that the recognition and treatment of neuropathic pain may increase the success of Psoriatic Arthritis treatment.
References
- 1. Felquer MA, FitzGerald O. Peripheral joint involvement in psoriatic arthritis patients. Clin Exp Rheumatol. 2015;33(93):S26-S30. 2. Kavanaugh A, Helliwell P, Ritchlin CT. Psoriatic arthritis and burden of disease: patient perspectives from the population-based multinational assessment of psoriasis and psoriatic arthritis (MAPP) survey. Rheumatology and therapy. 2016;3(1):91-102. 3. Mease PJ, Gladman DD, Papp KA, et al. Prevalence of rheumatologist-diagnosed psoriatic arthritis in patients with psoriasis in European/North American dermatology clinics. Journal of the American Academy of Dermatology. 2013;69(5):729-735. 4. Kemal N, Kilic E, Cevik R, et al. Management of psoriatic arthritis: Turkish League Against Rheumatism (TLAR) expert opinions. Archives of rheumatology. 2018;33(2):108.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | September 30, 2023 |
| Submission Date | September 29, 2022 |
| Published in Issue | Year 2023 Volume: 13 Issue: 3 |
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