Tip 1 Diyabetes Mellituslu Çocuklarda Ortalama Trombosit Hacmi ile Metabolik Kontrol Arasındaki İlişki

Abstract

Amaç: Bu çalışmada, tip 1 diyabetes mellituslu (T1DM) çocuklarda ortalama trombosit hacmi (MPV) ve trombosit sayısı gibi trombosit morfolojisi indekslerinin sağlıklı çocuklarla karşılaştırılması ve metabolik kontrol düzeyleri ile ilişkilerinin değerlendirilmesi amaçlanmıştır. Yöntem: Retrospektif, kesitsel, kontrollü karşılaştırmalı bu çalışma, Eylül 2020–Şubat 2021 tarihleri arasında üçüncü basamak bir hastanenin çocuk endokrinoloji polikliniğinde yürütüldü. Çalışma evrenini belirtilen dönemde polikliniğe başvuran ve en az bir yıldır T1DM tanısı ile izlenen tüm çocuklar oluşturdu; evrenin tamamı çalışmaya dâhil edildiğinden örneklem seçimi yapılmadı. Kontrol grubunu diyabet dışı nedenlerle başvuran ve tam kan sayımı yapılan sağlıklı çocuklar oluşturdu. Akut enfeksiyonu, diyabetik ketoasidozu olan veya trombosit fonksiyonunu etkileyebilecek ilaç kullanan çocuklar çalışma dışı bırakıldı. Demografik veriler, antropometrik ölçümler ve laboratuvar bulguları hasta dosyalarından kaydedildi. Tüm olgularda MPV ve trombosit sayısı karşılaştırıldı. İstatistiksel analizde veriler ortalama ± standart sapma (SS) olarak sunuldu; gruplar arasındaki karşılaştırmalarda uygun parametrik veya non-parametrik testler kullanıldı ve p <0,05 anlamlı kabul edildi. Bulgular: Çalışmaya 90 T1DM’li çocuk ve 50 sağlıklı çocuk dahil edildi. Gruplar arasında yaş ve cinsiyet açısından anlamlı fark yoktu (sırasıyla p=0,628 ve p=0,816). Hasta grubunun ortalama diyabet süresi 4,3±2,1 yıl olup olguların %32’si pubertal dönemdeydi. T1DM grubunun ortalama glikozillenmiş hemoglobin (HbA1c) değeri %10,4±2,4 bulundu. Trombosit sayısı (352.000 ± 135.000/µL ve 300.000 ± 128.000/µL; p=0,056) ve MPV değerleri (10,3 ± 1,05 fL ve 10,0 ± 1,67 fL; p=0,256) açısından T1DM ve kontrol grupları arasında anlamlı fark saptanmadı. MPV ile yaş, HbA1c ve diyabet süresi arasında anlamlı ilişki gözlenmedi. Sonuç: T1DM’li çocuklarda MPV ve trombosit sayısı sağlıklı çocuklara benzer bulundu. Bu durum, çocukluk çağında hastalık süresinin kısa olması ve komplikasyonların henüz gözlenmemiş olmasına bağlı olabilir. Daha geniş örneklemli, prospektif çalışmalarla çocukluk döneminde MPV’nin metabolik kontrol göstergesi olarak kullanılabilirliği değerlendirilmelidir.

Keywords

• Tip 1 diyabetes mellitus
• Ortalama trombosit hacmi
• Glikozillenmiş hemoglobin

Supporting Institution

yok

Ethical Statement

Çalışma onayı, XXX Üniversitesi Girişimsel Olmayan Klinik Araştırmalar Etik Kurulundan alındı. Tarih: 31.08.2020. Karar No: HRU20.15.26.

Thanks

yok

Association Between Mean Platelet Volume and Metabolic Control in Children with Type 1 Diabetes Mellitus

Abstract

Objective: To compare mean platelet volume (MPV) and platelet count in children with type 1 diabetes mellitus (T1DM) and healthy controls and to evaluate their relationships with metabolic control. Method: This retrospective, cross-sectional study was conducted between September 2020 and February 2021 in a tertiary paediatric endocrinology clinic. Children aged 3–18 years who had been followed for T1DM for at least one year and met the eligibility criteria were included. Controls were children who underwent a complete blood count for reasons unrelated to diabetes. Children with acute infection or diabetic ketoacidosis and those using medications that could affect platelet function were excluded. Data were obtained from medical records. MPV and platelet count were compared between groups. Data were expressed as mean ± standard deviation, appropriate parametric or non-parametric tests were used, and p <0.05 was considered statistically significant. Results: The study included 90 children with T1DM and 50 healthy controls. The groups did not differ significantly in age or sex (p=0.628 and p=0.816, respectively). The mean diabetes duration was 4.3 ± 2.1 years, and 32% of the participants were pubertal. The mean glycated hemoglobin (HbA1c) level in the T1DM group was 10.4% ± 2.4%. Platelet counts (352,000 ± 135,000/µL vs. 300,000 ± 128,000/µL; p=0.056) and MPV values (10.3 ± 1.05 fL vs. 10.0 ± 1.67 fL; p=0.256) were similar between the T1DM and control groups. MPV was not significantly associated with age, HbA1c, or diabetes duration. Conclusion: MPV and platelet counts in children with T1DM were similar to those in healthy children. This finding may reflect the relatively short disease duration and absence of established complications in childhood. Larger prospective studies are needed to clarify whether MPV can be used as a marker of metabolic control in children.

Keywords

• Type 1 diabetes mellitus
• Mean platelet volume
• Glycated hemoglobin

Supporting Institution

none

Ethical Statement

The study was approved by the Non-Interventional Clinical Research Ethics Committee of XXX University. Date: 31 August 2020. Decision No: HRU20.15.26.

Thanks

none

References

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