ACTN3 (rs1815739) GENİ İLE DARBEYE BAĞLI OLMAYAN SPOR YARALANMALARI İLİŞKİSİNİN İNCELENMESİ

Year 2023, , 145 - 157, 30.12.2023

Sedat Kahya

https://doi.org/10.33689/spormetre.1290017

Abstract

Günümüz dünyasında sporun artan popülaritesi ve sporcuların performans limitlerinin ötesine geçme isteği beraberinde birtakım sorunları gündeme getirmiştir. Bu sorunlardan biri olan spor yaralanmaları, spora ayrılan zamanın kaybolması ile sonuçlanan multifaktöriyel özelliğe sahip olumsuz bir durumdur. Spor yaralanmalarının oluş mekanizmaları dikkate alındığında, içsel ve dışsal birçok faktörün bu fenomen üzerinde önemli etkilere sahip olduğu görülmektedir. Bu faktörlerden biri olmaya aday genetik, sporcuları yumuşak doku yaralanmalarına karşı daha duyarlı hâle getirebilmektedir. Derleme, bugüne kadar ACTN3 rs1815739 gen polimorfizmi ve spor yaralanmaları ile ilgili internet veri tabanına kayıtlı çalışmaların değerlendirmesini içermektedir. ACTN3 rs1815739 gen polimorfizmi, kaslarda aktin filamentlerinin Z diskine bağlanmasını sağlayan alfa aktinin 3 proteinini kodlamaktadır. Aktin miyofilamentleri, kas fibrillerinin kasılma fonksiyonunda önemli bir göreve sahiptir. ACTN3 geninin kodladığı alfa aktinin proteini, kan ve kasdaki seviyeye bağlı olarak kas morfolojisini etkileyebilmektedir. Sonuç olarak, ACTN3 rs1815739 gen polimorfizmindeki genotip ve aleller darbeye bağlı olmayan kas yaralanmalarının mekanizmasını önemli ölçüde değiştirebilmektedir.

Keywords

ACTN3 geni, kas, spor, yaralanma, yumuşak doku

INVESTIGATION OF THE RELATIONSHIP BETWEEN ACTN3 (rs1815739) GENE AND NON-CONTACT SPORTS INJURIES

Abstract

In today's world, the increasing popularity of sports and the desire of athletes to go beyond the performance limits have brought with them a number of problems. Sports injuries, one of these problems, is a negative condition with a multifactorial feature that results in the loss of time allocated to sports. When the mechanisms of occurrence of sports injuries are considered, it is seen that many internal and external factors have significant effects on this phenomenon. Genetics, which is a candidate for one of these factors, may make athletes more susceptible to soft tissue injuries. The review includes an evaluation of the studies recorded to date in the online database on ACTN3 rs1815739 gene polymorphism and sports injuries. The ACTN3 rs1815739 gene polymorphism encodes the alpha actin 3 protein that enables actin filaments in muscles to bind to the Z disc. Actin myofilaments have an important role in the contractile function of muscle fibrils. The alpha actin protein encoded by the ACTN3 gene can affect muscle morphology depending on the level in the blood and muscle. As a result, genotypes and alleles in the ACTN3 rs1815739 gene polymorphism can significantly alter the mechanism of non-contact muscle injuries.

Keywords

ACTN3 gene, injury, muscle, soft tissue, sport

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