ERYTHROCYTE MEMBRANE FATTY ACID COMPOSITION OF DEPRESSIVE PATIENTS

Abstract

Abstract Major depressive disorder (MDD) is a serious affective illness. Eventhough association of some fatty acids and depression is reported, there is no information on composition of total fatty acids in erythrocyte mebranes. The present study was aimed to investigate for a possible relationship between depression and fatty acid composition of erythrocyte membranes. For this purpose, 30 patients diagnosed with major unipolar depression and 30 healthy control groups without any depression symptoms were formed. In these groups, erythrocyte membrane fatty acid composition was detected by Gas Chromatopgraphy. According to our results, unsaturated fatty acid levels in depressive patients were lower than in control group. The level of some fatty acids, especially with 18 to 22 carbon fatty acids, was reduced. The reduction of some fatty acids in erythrocyte mebranes during depression may indicate an alteration or a defect in polyunsaturated fatty acid (PUFA) methabolism in depressive patients. Özet Majör depresif bozukluk (MDB) ciddi bir duygudurum hastalığıdır. Bazı yağ asitlerinin depresyonla ilişkisi bildirilse de eritrosit zarlarındaki toplam yağ asitlerinin bileşimi hakkında literatürde yeterli bilgi mevcut değildir. Bu çalışma ile depresyon ile eritrosit membranlarının yağ asidi bileşimi arasındaki olası bir ilişkiyi araştırmak amaçlanmıştır. Bu amaçla majör unipolar depresyon tanısı alan 30 hasta ve herhangi bir depresyon belirtisi olmayan 30 sağlıklı kontrol grubu oluşturuldu. Bu gruplarda eritrosit membran yağ asidi kompozisyonu Gaz Kromatografisi ile tespit edildi. Sonuçlarımıza göre depresif hastalarda doymamış yağ asidi düzeyleri kontrol grubuna göre daha düşüktü. Özellikle 18 ila 22 karbonlu yağ asitleri ile bazı yağ asitlerinin seviyesinin düşük olduğu tespit edildi. Depresyon sırasında eritrosit zarlarındaki bazı yağ asitlerinin azalması, depresif hastalarda çoklu doymamış yağ asidi (PUFA) metabolizmasında bir değişikliği veya bir bozukluğu gösterebilir.

Keywords

• Deppresive patients
• Erytrocytes membranes
• Fatty acids
• Gas Chromatopgraphy

Supporting Institution

Tokat Gaziosmanpaşa Ünivrsitesi Bilimsel Araştırma Projeleri Başkanlığı

Project Number

: 2007/23

Thanks

The authors thank to Feryal Çam Çelikel and Meryem Dumanlı for the critical review of the article and the kind assistance in obtaining the patient’s samples.

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