Objectives: Postdural puncture headache (PDPH) is a complication that may arise following spinal anesthesia. We investigated whether homocysteine and C-reactive protein levels may be associated in the development of PDPH in patients that received spinal anesthesia.
Materials and Methods: In order to determine homocysteine and C-reactive protein (CRP) levels, blood samples were taken from patients before and one day following spinal anesthesia. A total of 100 male patients were enrolled in the study. The mean age of the patients was 29 years old. Out of all the patients, a total of 6 developed headaches. The Mann-Whitney U-test was used to compare homocysteine and CRP levels between patients that did and did not develop headaches.
Results: Homocysteine levels before and after the operation were higher in subjects that developed a headache as compared to patients that did not develop headaches (p<0.001). CRP levels did not differ significantly between patients with headaches and patients that did not experience them (p>0.05).
Conclusions: High blood levels of homocysteine in patients with
PDPH might be used as a biomarker so to predict the development of PDPH.
However, future larger, multi-center studies are needed to further elucidate
|Subjects||Primary Health Care|
|Journal Section||Research Articles|
|Supporting Institution||Erzincan Binali Yıldırım Üniversitesi Bilimsel Araştırma Projesi|
|Publication Date||August 30, 2019|
|Submission Date||August 1, 2019|
|Acceptance Date||August 29, 2019|
|Published in Issue||Year 2019, Volume 1, Issue 1|
|APA||Şahin, M. , Peker, K. & Bozkurt, A. S. (2019). In patients receiving spinal anesthesia, can homocysteine and C-reactive protein levels predict the development of postdural puncture headache? . Sabuncuoglu Serefeddin Health Sciences , 1 (1) , 34-41 . Retrieved from https://dergipark.org.tr/en/pub/sshs/issue/48459/599681|