In patients receiving spinal anesthesia, can homocysteine and C-reactive protein levels predict the development of postdural puncture headache?

Year 2019, Volume: 1 Issue: 1, 34 - 41, 30.08.2019

Murat Şahin , Kemal Peker , Ali Seydi Bozkurt

Abstract

Objectives: Postdural
puncture headache (PDPH) is a complication that may arise following spinal
anesthesia. We investigated whether homocysteine and C-reactive protein levels may
be associated in the development of PDPH in patients that received spinal
anesthesia.

Materials and Methods: In order to determine homocysteine and C-reactive protein (CRP) levels,
blood samples were taken from patients before and one day following spinal
anesthesia. A total of 100 male patients were enrolled in the study. The mean
age of the patients was 29 years old. Out of all the patients, a total of 6
developed headaches. The Mann-Whitney U-test was used to compare homocysteine
and CRP levels between patients that did and did not develop headaches.

Results: Homocysteine
levels before and after the operation were higher in subjects that developed a
headache as compared to patients that did not develop headaches (p<0.001). CRP
levels did not differ significantly between patients with headaches and
patients that did not experience them (p>0.05).

Conclusions: High blood levels of homocysteine in patients with
PDPH might be used as a biomarker so to predict the development of PDPH.
However, future larger, multi-center studies are needed to further elucidate
this association.

Keywords

Spinal Anesthesia, Postdural Puncture Headache, Homocysteine, C-Reactive Proteine

Project Number

2012/12.01.08

References

• Referans 1.Bedirli N, Akkaya T: Postspinal Başağrısı. Anestezi Dergisi. 2010:18(3):135-140