INVESTIGATION OF THE FREQUENCY OF MICROSATELLITE INSTABILITY FROM PATHOLOGICAL TISSUE SAMPLES OF PATIENTS WITH GASTRIC CANCER AND ITS EFFECT ON DISEASE PROGNOSIS AND TREATMENT

Year 2025, Volume: 7 Issue: 1, 17 - 21, 30.04.2025

Husnu Serdar Kiziltunc , Salim Başol Tekin

Abstract

Gastric cancers continues to be one of the most important health problems in our society with high morbidity and mortality rates. Based on genomic characterization, gastric cancer has recently been defined as a heterogeneous disease consisting of different subtypes, each with unique molecular features and specific clinics. In this study, we tried to investigate the frequency of microsatellite instability in gastric cancers and its effects on the disease. In our study, microsatellite instability results of the patients were seen as microsatellite stable (MSS) in 45 (90%) patients, microsatellite instability high (MSI-H) in 2 (4%) patients and microsatellite instability low (MSI-L) in 3 (6%) patients. It was observed that microsatellite stability was an independent risk factor for mortality. (p=0.035). As a result, it was seen that microsatellite stability was a negative risk factor for mortality in gastric cancer, however, it was concluded that microsatellite instability should be evaluated together with other risk factors that may have an effect on the disease.

Keywords

Gastric cancer , Microsatellite instability , Morbidity , Mortality , Treatment

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