The Relationship of COMP and MMP-3 Levels with Radiographic and Clinical Findings in Knee Osteoarthritis

Öz

Purpose: Osteoarthritis is the most common joint disease affecting the knee joints mostly. The aim of this study was to investigate the relationship between radiological stages of the disease and daily life activity levels of the patient and serum cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3(MMP-3) levels in patients with knee osteoarthritis. Material and Methods: Eighty-five patients were divided into three groups according to Kellgren-Lawrence scale. In the 1st group Stage I, in the 2nd group Stage II/III and in the 3rd group Stage IV patients were included. Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Lequesne algofunctional knee index, and Knee Injury and Osteoarthritis Outcome Score Short Form (KOOS-PS) were used to evaluate the severity of pain and functional status in daily life activities of patients. Results: In all three patient groups serum COMP and MMP-3 levels were found to be similar. A weak correlation was found between serum COMP levels and VAS (p=0.682), Lequesne (p=0.941) scores. There was also a weak correlation between serum MMP-3 levels and VAS (p=0.911), Lequesne (p=0.636) and KOOS-PS (p=0.965). Conclusion: No significant differences were found in serum COMP and MMP-3 levels between different radiological stages of knee osteoarthritis groups and the clinical parameters as severity of pain and functional status in daily life activities. Further studies with larger sample groups are needed on this issue.

Anahtar Kelimeler

• Knee
• Osteoartritis
• Radiography
• COMP
• MMP-3
• Function
• Pain

Diz Osteoartritinde COMP ve MMP-3 Düzeylerinin Radyografik ve Klinik Bulgularla İlişkisi

Öz

Amaç: Osteoartrit, çoğunlukla dizleri etkileyen en yaygın eklem hastalığıdır. Bu çalışmanın amacı diz osteoartriti olan hastalarda hastalığın radyolojik evreleri ve hastanın günlük yaşam aktivite düzeyleri ile serum kıkırdak oligomerik matriks proteini (COMP) ve matriks metaloproteinaz-3 (MMP-3) düzeyleri arasındaki ilişkiyi araştırmaktır. Materyal ve Metod: Seksen beş hasta Kellgren-Lawrence ölçeğine göre üç gruba ayrıldı. 1. grup Evre I, 2. grup Evre II/III ve 3. grup Evre IV hastalar dahil edildi. Hastaların günlük yaşam aktivitelerinde ağrı şiddetini ve fonksiyonel durumlarını değerlendirmek için Görsel Analog Skala (VAS), Western Ontario ve McMaster Üniversiteleri Osteoartrit İndeksi (WOMAC), Lequesne indeksi ve Diz Yaralanması ve Osteoartrit Sonuç Skoru Kısa Formu (KOOS-PS) kullanıldı. Bulgular: Her üç hasta grubunda da serum COMP ve MMP-3 düzeyleri benzer bulundu. Serum COMP düzeyleri ile VAS (p=0.682), Lequesne (p=0.941) skorları arasında zayıf korelasyon saptandı. Serum MMP-3 düzeyleri ile VAS (p= 0.911), Lequesne (p=0.636) ve KOOS-PS (p=0.965) arasında da zayıf bir korelasyon olduğu belirlendi. Sonuç: Diz osteoartrit gruplarının farklı radyolojik evreleri ile günlük yaşam aktivitelerinde ağrı şiddeti ve fonksiyonel durum olan klinik parametreler ile serum COMP ve MMP-3 düzeyleri arasında anlamlı farklılık saptanmadı.

Anahtar Kelimeler

• Diz
• Osteoartrit
• Radyografi
• COMP
• MMP-3
• Fonksiyon
• Ağrı

Kaynakça

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