Araştırma Makalesi
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Peripheral Intravenous Cannula Location and the Effect of the Antiseptic Solution on the Development of Thrombophlebitis: A Quasi-Experimental Study

Yıl 2026, Cilt: 34 Sayı: 6, 441 - 451, 12.02.2026
https://izlik.org/JA77UJ77DU

Öz

Aim: Peripheral Intravenous Cannulae (PIVC) are an indispensable tool in modern medical treatment; however, their misapplication may lead to preventable complications such as thrombophlebitis. The location of the cannula and the antiseptic solution utilised have been hypothesised to exert an influence on the development of thrombophlebitis. The present study was conducted with the objective of investigating the effects of PIVC site and antiseptic solution on the development of thrombophlebitis.
Methods: The present study adopts a quasi-experimental design, employing a pre- and post-test model. PIVC was applied to the veins of the dorsum of the hand, forearm and cubital fossa, which were determined according to the patient's condition, using 70% alcohol, 10% povidone iodine or 2% chlorhexidine antiseptic solutions sequentially. The cannula site was observed at 24-hour intervals post-application using the Visual Phlebitis Scale, with the results documented on the designated form. In this study, a total of 341 PIVC were observed for a maximum of 96 hours.
Results: Following the conclusion of the study, it was determined that the optimal cannula location for the prevention of thrombophlebitis was the dorsum of the hand, and that the most efficacious antiseptic solution was 10% povidone iodine.
Conclusion: Thrombophlebitis has been an important complication in the context of PIVC applications from past to present. The present study determined that the location of the PIVC and the aseptic solution used are effective in the development of thrombophlebitis. It is thought that performing cannula applications in this direction may prevent the complication of thrombophlebitis.

Kaynakça

  • Maier D. To Replace or Not to Replace? Replacing short peripheral catheters based on clinical indication. J Infus Nurs. 2019;42(3):143–8.
  • Oliveira ADSS, Basto ML, Braga LM, Sena CA, Melo MN, Parreira PMDSD. Nursing practices in peripheral venous catheter: Phlebitis and patient safety. Texto e Context Enferm. 2019;28:1–13.
  • Ray-Barruel G, Xu H, Marsh N, Cooke M, Rickard CM. Effectiveness of insertion and maintenance bundles in preventing peripheral intravenous catheter-related complications and bloodstream infection in hospital patients: A systematic review. Infect Dis Heal [Internet]. 2019;24(3):152–68. Available from: https://doi.org/10.1016/j.idh.2019.03.001
  • Lulie M, Tadesse A, Tsegaye T, Yesuf T, Silamsaw M. Incidencia de flebitis por catéter intravenoso periférico y sus factores asociados entre pacientes ingresados en el hospital de la Universidad de Gondar, noroeste de Etiopía: un estudio. Thromb J [Internet]. 2021;19(1):1–8. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276507/pdf/12959_2021_Article_301.pdf
  • Kassahun CW, Abate AT, Tezera ZB, Beshah DT, Agegnehu CD, Getnet MA, et al. Incidence and associated factors of failed first peripheral intravenous catheters among adult patients at medical surgical wards in Public Referral Hospitals of West Amhara, Ethiopia, 2021. Nurs Res Pract. 2022;2022:8261225
  • Tolpadi A, Mane A, Modak M, Verma AK, Ambekar V, Shilawat T. Impact of interventions on the incidence of thrombophlebitis in peripheral venous cannulation in a tertiary care teaching hospital. Int Surg J. 2021;8(7):2007.
  • Uslusoy E, Mete S. Predisposing factors to phlebitis in patients with peripheral intravenous catheters: A descriptive study. J Am Acad Nurse Pract. 2008;20(4):172–80.
  • Infusion Nurses Society. Infusión Nursing Standards of Practice [Internet]. Journal of Infusion Nursing: The official publication of the Infusion Nurses Society. 2011;34:50–70 Available at: http://www.vardhandboken.se/Dokument/INS_2011.pdf
  • Lv L, Zhang J. The incidence and risk of infusion phlebitis with peripheral intravenous catheters: A meta-analysis. J Vasc Access. 2020;21(3):342–9.
  • Cicolini G, Bonghi AP, Di Labio L, Di Mascio R. Position of peripheral venous cannulae and the incidence of thrombophlebitis: An observational study. J Adv Nurs. 2009;65(6):1268–73.
  • Sheikhi A, Asadizaker M, Jahani S, Koochak M, Shamlo M, Zadeh M. The Effect of Rosemary topical ointment on phlebitis caused by antibiotic therapy in intensive care units. J Int Pharm Res. 2018;45(January):5–11.
  • O’Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, et al. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis. 2011;52(9):e162-93.
  • Nyamuryekung’e MK, Mmari EE, Patel MR. A missing piece: Fracture of peripheral intravenous cannula, a case report. Int J Surg Case Rep. 2021;78:296–9.
  • Nassaji-Zavareh M, Ghorbani R. Peripheral intravenous catheter-related phlebitis and related risk factors. Singapore Med J. 2007;48(8):733–6.
  • Van der Mee-Marquet NL, Amirault P, Besnard P, Bloc D, Branger B, Boucher MF, et al. Efficacy and safety of a two-step method of skin preparation for peripheral intravenous catheter insertion: A prospective multi-centre randomised trial. BMC Anesthesiol. 2007;7:1–8.
  • Simin D, Milutinović D, Turkulov V, Brkić S. Incidence, severity and risk factors of peripheral intravenous cannula-induced complications: An observational prospective study. J Clin Nurs. 2019;28(9–10):1585–99.
  • Anselmi ML, Peduzzi M, Benedita dos Santos C. Errors in the administration of intravenous medications in university hospital. Int J Clin Pharm [Internet]. 2013;35(5):980–1. Available at: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L71239735%5Cnhttp://dx.doi.org/10.1007/s11096-013-9801-0
  • Thwaites RS, Uruchurtu ASS, Siggins MK, Liew F, Russell CD, Moore SC, et al. Info _ Outline. Crit Rev Clin Lab Sci [Internet]. 2020;8(1):1–5.
  • Jackson A. Reflecting on the nursing contribution to vascular access. Br J Nurs. 2003;12(11):657–65.
  • Infusion Nurses Society (INS). Infusion Nursing Standards of Practice [Internet]. Journal of Infusion Nursing. 2011;34. 1–110. Available at: http://engage.ahima.org/HigherLogic/System/DownloadDocumentFile.ashx?DocumentFileKey=2238ee0a-c2df-4d1a-affa-f69f2ce41856
  • Jamal Z, Umair M, Zubair R, Zafar N, Rauf F, Affif M. Peripheral intravenous catheter related thrombophlebitis-incidence and risk factors: A Cross Sectional Study. Journal SJRMU [Internet]. 2019;23(1):22–7. Available from: http://www.journalrmc.com/index.php/JRMC/article/view/1030
  • Atay S, Sen S, Cukurlu D. Phlebitis-related peripheral venous catheterization and the associated risk factors. Niger J Clin Pract. 2018;21(7):827–31.
  • Joae Brett Nito P, Sari Mulia Banjarmasin S, Ahmad Yani S. Relationship of age, gender, location insertion and catheter size of incidence phlebitis. Din Kesehat. 2017;8(2):365–75.
  • Guenezan J, Marjanovic N, Drugeon B, Neill RO, Liuu E, Roblot F, et al. Chlorhexidine plus alcohol versus povidone iodine plus alcohol, combined or not with innovative devices, for prevention of short-term peripheral venous catheter infection and failure (CLEAN 3 study): An investigator-initiated, open-label, single centre, r. Lancet Infect Dis. 2021;21(7):1038–48.
  • Gunasegaran N, See MTA, Leong ST, Yuan LX, Ang SY. A randomized controlled study to evaluate the effectiveness of 2 treatment methods in reducing incidence of short peripheral catheter-related phlebitis. J Infus Nurs. 2018;41(2):131–7.
  • Myaneh ZT, Alizadeh SA, Shahrokhi A, Rashvand F. Comparing the effects of chlorhexidine 2% and iodopovidone-alcohol on peripheral venous catheter bacterial colonization in preterm neonates. Iran J Neonatol. 2019;10(3):64–9.
  • Yasuda H, Sanui M, Abe T, Shime N, Komuro T, Hatakeyama J, et al. Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: A multicenter randomized controlled study. Crit Care. 2017;21(1):1–10.
  • Guanche-Sicilia A, Sánchez-Gómez MB, Castro-Peraza ME, Rodríguez-Gómez JÁ, Gómez-Salgado J, Duarte-Clíments G. Prevention and treatment of phlebitis secondary to the insertion of a peripheral venous catheter: A scoping review from a nursing perspective. Healthc. 2021;9(5):1–24.
  • Öztürk E, Erdđl FA, Begeç Z, Yücel A, Şanli M, Malatya T. The effects of ice on intravenous cannulation pain. Fırat Tıp Derg (Firat Med Journal) [Internet]. 2009;14(2):108–10. Available at: http://www.firattipdergisi.com/text.php3?id=553
  • Nobre A, Martins M. Prevalence of peripheral intravenous catheter-related phlebitis: Associated factors. Rev Enferm Ref. 2018;IV Série(No16):127–38.
  • Chang WP, Peng YX. Occurrence of phlebitis: A systematic review and meta-analysis. Nurs Res. 2018;67(3):252–60.

Periferik İntravenöz Kanül Yeri ve Antiseptik Solüsyonun Tromboflebit Gelişimi Üzerindeki Etkisi: Yarı Deneysel Bir Çalışma

Yıl 2026, Cilt: 34 Sayı: 6, 441 - 451, 12.02.2026
https://izlik.org/JA77UJ77DU

Öz

Amaç: Periferik Intravenöz Kanüller (PIVK), modern tıbbi tedavide vazgeçilmez bir araçtır; ancak yanlış kullanımı, tromboflebit gibi önlenebilir komplikasyonlara yol açabilir. Kanülün yerleştirildiği bölge ve kullanılan antiseptik solüsyonun tromboflebit gelişimini etkilediği bilinmektedir. Bu çalışma, PIVK yerleştirilen bölge ve antiseptik solüsyonun tromboflebit gelişimine etkisini araştırmak amacıyla yapılmıştır.
Yöntemler: Bu çalışma, ön test ve son test modelini kullanan yarı deneysel bir tasarımdadır. PIVK uygulaması, hastanın durumuna göre belirlenen el üstü, önkol ve antekübital bölge damarlarına, sırasıyla %70 alkol, %10 povidon iyot ve %2 klorheksidin antiseptik solüsyonları kullanılarak gerçekleştirilmiştir. Kanül bölgesi, uygulama sonrası 24 saatlik aralıklarla Görsel Flebit Ölçeği kullanılarak gözlemlenmiş ve sonuçlar kaydedilmiştir. Bu çalışmada, toplam 341 PIVK maksimum 96 saat boyunca gözlemlenmiştir.
Bulgular: Çalışmanın sonunda, tromboflebitin önlenmesi için en uygun kanül yerinin el üstü olduğu ve en etkili antiseptik solüsyonun %10 povidon iyot olduğu belirlenmiştir.
Sonuç: Tromboflebit, geçmişten günümüze PIVK uygulamaları bağlamında önemli bir komplikasyon olmuştur. Bu çalışma, PIVK'nın yeri ve kullanılan antiseptik solüsyonun tromboflebit gelişiminde etkili olduğunu belirlemiştir.

Etik Beyan

Atatürk Üniversitesi Sağlık Bilimleri Esntitüsü Etik Kurulu 018448 nolu karar ile onaylanmıştır.

Kaynakça

  • Maier D. To Replace or Not to Replace? Replacing short peripheral catheters based on clinical indication. J Infus Nurs. 2019;42(3):143–8.
  • Oliveira ADSS, Basto ML, Braga LM, Sena CA, Melo MN, Parreira PMDSD. Nursing practices in peripheral venous catheter: Phlebitis and patient safety. Texto e Context Enferm. 2019;28:1–13.
  • Ray-Barruel G, Xu H, Marsh N, Cooke M, Rickard CM. Effectiveness of insertion and maintenance bundles in preventing peripheral intravenous catheter-related complications and bloodstream infection in hospital patients: A systematic review. Infect Dis Heal [Internet]. 2019;24(3):152–68. Available from: https://doi.org/10.1016/j.idh.2019.03.001
  • Lulie M, Tadesse A, Tsegaye T, Yesuf T, Silamsaw M. Incidencia de flebitis por catéter intravenoso periférico y sus factores asociados entre pacientes ingresados en el hospital de la Universidad de Gondar, noroeste de Etiopía: un estudio. Thromb J [Internet]. 2021;19(1):1–8. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276507/pdf/12959_2021_Article_301.pdf
  • Kassahun CW, Abate AT, Tezera ZB, Beshah DT, Agegnehu CD, Getnet MA, et al. Incidence and associated factors of failed first peripheral intravenous catheters among adult patients at medical surgical wards in Public Referral Hospitals of West Amhara, Ethiopia, 2021. Nurs Res Pract. 2022;2022:8261225
  • Tolpadi A, Mane A, Modak M, Verma AK, Ambekar V, Shilawat T. Impact of interventions on the incidence of thrombophlebitis in peripheral venous cannulation in a tertiary care teaching hospital. Int Surg J. 2021;8(7):2007.
  • Uslusoy E, Mete S. Predisposing factors to phlebitis in patients with peripheral intravenous catheters: A descriptive study. J Am Acad Nurse Pract. 2008;20(4):172–80.
  • Infusion Nurses Society. Infusión Nursing Standards of Practice [Internet]. Journal of Infusion Nursing: The official publication of the Infusion Nurses Society. 2011;34:50–70 Available at: http://www.vardhandboken.se/Dokument/INS_2011.pdf
  • Lv L, Zhang J. The incidence and risk of infusion phlebitis with peripheral intravenous catheters: A meta-analysis. J Vasc Access. 2020;21(3):342–9.
  • Cicolini G, Bonghi AP, Di Labio L, Di Mascio R. Position of peripheral venous cannulae and the incidence of thrombophlebitis: An observational study. J Adv Nurs. 2009;65(6):1268–73.
  • Sheikhi A, Asadizaker M, Jahani S, Koochak M, Shamlo M, Zadeh M. The Effect of Rosemary topical ointment on phlebitis caused by antibiotic therapy in intensive care units. J Int Pharm Res. 2018;45(January):5–11.
  • O’Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, et al. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis. 2011;52(9):e162-93.
  • Nyamuryekung’e MK, Mmari EE, Patel MR. A missing piece: Fracture of peripheral intravenous cannula, a case report. Int J Surg Case Rep. 2021;78:296–9.
  • Nassaji-Zavareh M, Ghorbani R. Peripheral intravenous catheter-related phlebitis and related risk factors. Singapore Med J. 2007;48(8):733–6.
  • Van der Mee-Marquet NL, Amirault P, Besnard P, Bloc D, Branger B, Boucher MF, et al. Efficacy and safety of a two-step method of skin preparation for peripheral intravenous catheter insertion: A prospective multi-centre randomised trial. BMC Anesthesiol. 2007;7:1–8.
  • Simin D, Milutinović D, Turkulov V, Brkić S. Incidence, severity and risk factors of peripheral intravenous cannula-induced complications: An observational prospective study. J Clin Nurs. 2019;28(9–10):1585–99.
  • Anselmi ML, Peduzzi M, Benedita dos Santos C. Errors in the administration of intravenous medications in university hospital. Int J Clin Pharm [Internet]. 2013;35(5):980–1. Available at: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L71239735%5Cnhttp://dx.doi.org/10.1007/s11096-013-9801-0
  • Thwaites RS, Uruchurtu ASS, Siggins MK, Liew F, Russell CD, Moore SC, et al. Info _ Outline. Crit Rev Clin Lab Sci [Internet]. 2020;8(1):1–5.
  • Jackson A. Reflecting on the nursing contribution to vascular access. Br J Nurs. 2003;12(11):657–65.
  • Infusion Nurses Society (INS). Infusion Nursing Standards of Practice [Internet]. Journal of Infusion Nursing. 2011;34. 1–110. Available at: http://engage.ahima.org/HigherLogic/System/DownloadDocumentFile.ashx?DocumentFileKey=2238ee0a-c2df-4d1a-affa-f69f2ce41856
  • Jamal Z, Umair M, Zubair R, Zafar N, Rauf F, Affif M. Peripheral intravenous catheter related thrombophlebitis-incidence and risk factors: A Cross Sectional Study. Journal SJRMU [Internet]. 2019;23(1):22–7. Available from: http://www.journalrmc.com/index.php/JRMC/article/view/1030
  • Atay S, Sen S, Cukurlu D. Phlebitis-related peripheral venous catheterization and the associated risk factors. Niger J Clin Pract. 2018;21(7):827–31.
  • Joae Brett Nito P, Sari Mulia Banjarmasin S, Ahmad Yani S. Relationship of age, gender, location insertion and catheter size of incidence phlebitis. Din Kesehat. 2017;8(2):365–75.
  • Guenezan J, Marjanovic N, Drugeon B, Neill RO, Liuu E, Roblot F, et al. Chlorhexidine plus alcohol versus povidone iodine plus alcohol, combined or not with innovative devices, for prevention of short-term peripheral venous catheter infection and failure (CLEAN 3 study): An investigator-initiated, open-label, single centre, r. Lancet Infect Dis. 2021;21(7):1038–48.
  • Gunasegaran N, See MTA, Leong ST, Yuan LX, Ang SY. A randomized controlled study to evaluate the effectiveness of 2 treatment methods in reducing incidence of short peripheral catheter-related phlebitis. J Infus Nurs. 2018;41(2):131–7.
  • Myaneh ZT, Alizadeh SA, Shahrokhi A, Rashvand F. Comparing the effects of chlorhexidine 2% and iodopovidone-alcohol on peripheral venous catheter bacterial colonization in preterm neonates. Iran J Neonatol. 2019;10(3):64–9.
  • Yasuda H, Sanui M, Abe T, Shime N, Komuro T, Hatakeyama J, et al. Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: A multicenter randomized controlled study. Crit Care. 2017;21(1):1–10.
  • Guanche-Sicilia A, Sánchez-Gómez MB, Castro-Peraza ME, Rodríguez-Gómez JÁ, Gómez-Salgado J, Duarte-Clíments G. Prevention and treatment of phlebitis secondary to the insertion of a peripheral venous catheter: A scoping review from a nursing perspective. Healthc. 2021;9(5):1–24.
  • Öztürk E, Erdđl FA, Begeç Z, Yücel A, Şanli M, Malatya T. The effects of ice on intravenous cannulation pain. Fırat Tıp Derg (Firat Med Journal) [Internet]. 2009;14(2):108–10. Available at: http://www.firattipdergisi.com/text.php3?id=553
  • Nobre A, Martins M. Prevalence of peripheral intravenous catheter-related phlebitis: Associated factors. Rev Enferm Ref. 2018;IV Série(No16):127–38.
  • Chang WP, Peng YX. Occurrence of phlebitis: A systematic review and meta-analysis. Nurs Res. 2018;67(3):252–60.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Hemşirelik (Diğer)
Bölüm Araştırma Makalesi
Yazarlar

Özlem Albayrak 0000-0002-9167-307X

Mağfiret Kaşıkçı 0000-0001-5136-462X

Gönderilme Tarihi 18 Aralık 2023
Kabul Tarihi 27 Ocak 2026
Yayımlanma Tarihi 12 Şubat 2026
DOI https://doi.org/10.17942/sted.1406322
IZ https://izlik.org/JA77UJ77DU
Yayımlandığı Sayı Yıl 2026 Cilt: 34 Sayı: 6

Kaynak Göster

Vancouver 1.Albayrak Ö, Kaşıkçı M. Peripheral Intravenous Cannula Location and the Effect of the Antiseptic Solution on the Development of Thrombophlebitis: A Quasi-Experimental Study. STED [Internet]. 01 Şubat 2026;34(6):441-5. Erişim adresi: https://izlik.org/JA77UJ77DU