Bu çalışmada, organoselenyum bileşikler olarak 1-(fenilseleno)-3-siklohekzilamino-2 propanol (FSSP), 1-(p-metoksifenilseleno)-3-morfolino-2-propanol (p-MFSMP), 1-(p-bromofenilseleno)-3-morfolino-2-propanol (p-BFSMP) ve onların klorhidratları sentezlenmiş, hayvanlar üzerinde yapılan denemelerde lipid peroksidasyonu ve antioksidan aktivite (AOA) düzeyleri üzerine olan etkileri araştırılmıştır. Bunun için ağırlığı 25g olan 80 adet kobay, her birinde 10 adet olmak üzere 8 gruba ayrıldı. Sentezlenen organoselenyum bileşikler farelerin deri altına 40, 80, 120, 160, 200, 240, 320 mg/kg dozlarda verildi. Verilen bu dozlarda 24, 48 ve 72 saatlerde ölen hayvanların miktarı belirlendi. Sentezlenen organoselenyum bileşiklerden her birinin belirli toksik etkiye sahip olduğu, LD50 değerlerinin 160 mg/kg, LD100 değerlerinin 200-240 mg/kg olduğu ,en az toksik dozun 80 mg/kg olduğu belirlendi. Elde edilen sonuçlara göre sentezlenen organoselenyum bileşiklerin antioksidatif etkinliğe sahip olduğu ve bu bileşiklerin klorhidratlarının antioksidan aktivitelerinin FSSP > p- MFSMP > p- BFSMP gibi sıralandığı belirlenmiştir.
In this study, the polyfunctional organoselenium compounds such as 1- phenylseleno-3-cyclohexylamine-2-propanole(FSSP), 1-(p-methoxyphenylseleno)-3- morpholine-2-propanole (MFSMP), 1-(p-brominephenylseleno)-3-morpholine-2- propanole (BFSMP) and its chlorohydrats were synthesized, their toxic dose levels and lipid peroxidation and antioxidant activity (AOA) effects on animals were evaluated. For this purpose, 7 dose levels beginning with 40 mg/kg and following as 80 mg/kg, 120 mg/kg, 160 mg/kg, 200 mg/kg, 240 mg/kg, 320 mg/kg experimented under skin of the 8 groups each containing 10 guinea pigs which are 25 gr weight. After 24, 48 and 72 hours following administration of the chemicals, the numbers of dead and alive animals were recorded and morthalities were calculated. It was determined that all of the synthesized chlorohydrats organoselenium compounds has some toxic effect and LD50 value is 160 mg/kg, LD100 value is 200-240 mg/kg. The lowest morthality was in 80 mg/kg given group, whereas the highest morthality was found in 210 mg/kg group. Antioxidant activity of chlorohydrats organoselenium compounds was determined as following rank: FSSP > p- MFSMP > p- BFSMP
Other ID | JA58BZ27FR |
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Journal Section | Research Articles |
Authors | |
Publication Date | December 1, 2010 |
Submission Date | December 1, 2010 |
Published in Issue | Year 2010 Volume: 2 Issue: 35 |
Journal Owner: On behalf of Selçuk University Faculty of Science, Rector Prof. Dr. Hüseyin YILMAZ
Selcuk University Journal of Science Faculty accepts articles in Turkish and English with original results in basic sciences and other applied sciences. The journal may also include compilations containing current innovations.
It was first published in 1981 as "S.Ü. Fen-Edebiyat Fakültesi Dergisi" and was published under this name until 1984 (Number 1-4).
In 1984, its name was changed to "S.Ü. Fen-Edeb. Fak. Fen Dergisi" and it was published under this name as of the 5th issue.
When the Faculty of Letters and Sciences was separated into the Faculty of Science and the Faculty of Letters with the decision of the Council of Ministers numbered 2008/4344 published in the Official Gazette dated 3 December 2008 and numbered 27073, it has been published as "Selcuk University Journal of Science Faculty" since 2009.
It has been scanned in DergiPark since 2016.
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