Abstract
In the present study, an off-axis
cavity-enhanced absorption spectroscopy (OA-CEAS)-based optoelectronic sensor
is reported for analysis of water vapor present in breath. First, theoretical
study based on the HITRAN data base was performed in order to determine an
isolated absorption line for detection of water vapor. After that, the
experimental analysis of water vapor in breath was conducted using the
absorption line found out from the theoretical study. A
tunable laser system operating between the spectral range 1250 and 1350 nm was
used. This laser was coupled into the CEAS cell via a lens with a focal length
of 50 cm and a mirror. The cavity consists of two highly reflective mirrors
positioned 50 cm apart with a reflectivity of > 99.96% over the spectral range
between 700 and 1650 nm with a 2.54 cm diameter and a radius of curvature of 1
m.
References
- Bayraklı, I., Akman, H., 2015, "Ultrasensitive, real-time analysis of biomarkers in breath using tunable external cavity laser and off-axis cavity enhanced absorption spectroscopy," Journal of Biomedical Optics, cilt 20, sayı 3, ss. 037001-8.
- Bayraklı, I., 2015, "External cavity diode lasers-based off-axis cavity enhanced absorption spectroscopy in the spectral range between 1000 nm and 1620 nm for trace-gas measurements," Journal of Near Infrared Spectroscopy, cilt 23, sayı 4, ss. 237–243.
- Bayraklı, I., Öztürk, Ö., Akman, H., 2016, "Investigation of acetone, butanol, and carbon dioxide as new breath biomarkers for convenient and non-invasive diagnosis of obstructive sleep apnea syndrome," Biomedical Chromatography, cilt 30, sayı 12, ss. 1890-1899.
- Bayraklı, I., Türkmen, A., Koçkar, M. C., 2016, “Examination of feasibility of using breath ammonia analysis based on off-axis cavity-enhanced absorption spectroscopy with external cavity diode laser for non-invasive real-time diagnosis of Helicobacter Pylori," Applied Spectroscopy, cilt 70, sayı 8, pp. 1269–1277.
- Bayraklı, I., 2017, "Breath analysis using external cavity diode lasers: a review," Journal of Biomedical Optics, cilt 22, sayı 4, pp. 040901, ss. 1-15.
- Bielecki, Z., et al., 2015, "Application of quantum cascade lasers to trace gas detection," Bulletin of the polish academy of sciences technical sciences, cilt 63, ss. 515–525.
- Huh, J., Yi. B. Gam, D., 1613, Korea Traditional Medicine Book, Seoul, Korea: NaeYi Won.
- Jiang, C., Sun, M., Wang, Z., Chen, Z., Zhao, X., Yuan, Y., Li, Y., Wang, C., 2016, "A Portable Real-Time Ringdown Breath Acetone Analyzer: Toward Potential Diabetic Screening and Management, Sensors, cilt 16, sayı 1199, ss. 1-15.
- Pauling, L., Robinson, A. B., Teranishi, R., Cary, P., 1971, "Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography," Proc. Natl. Acad. Sci. USA, cilt 68, sayı 10, ss. 2374-2376.
- Risby, T. H., Tittel, F. K., 2010, "Current status of mid-infrared quantum and interband cascade lasers for clinical breath analysis," Optical Engineering, cilt 49, sayı 11, ss. 1-15.
- Wang, C., Sahay, P., 2009, "Breath analysis using laser spectroscopic techniques: breath biomarkers, spectral fingerprints, and detection Limits," Sensors, cilt 9, ss. 8230-8262.
Abstract
Bu çalışma kapsamında, biyomedikal uygulamalar
için kullanılabilecek olan eksen-dışı kovuk-artırılmış soğurma spektroskopisine
dayalı optoelektronik sensör kullanılarak nefeste bulunan su buharı analiz
çalışmaları yapılmıştır. İlk önce HITRAN veri tabanı kullanılarak teorik
çalışma yapılmış ve su buharı molekülünün algılanması için kullanılabilecek
olan soğurma çizgisi tespit edilmiştir. Ardından, bulunan soğurma çizgisi
kullanılarak nefesteki su buharı molekülü analiz edilmiştir. Bunun için 1250-1350 nm aralığında dalga boyu taranabilen
dış kavite diyot lazer sistemi kullanılmıştır. Lazerden çıkan ışın, 50 cm odak
uzaklığına sahip bir mercek ve bir ayna kullanılarak eksen dışı (off axis, OA)
düzenekte, kovuk artırılmış soğurma spektroskopi kovuğuna bağdaştırılmıştır.
Kovuk, 700 nm ile 1650 nm spektral aralığında çok yüksek geri yansıma
katsayısına sahip (% 99.96), 1 m eğrilik yarıçapında ve 2.54 cm çapında iki
tane aynadan oluşmaktadır. Bildiğimiz kadarıyla, su moleküllerinin analizi için
ilgili spektral alan ilk defa bu çalışmada kullanılmıştır.
References
- Bayraklı, I., Akman, H., 2015, "Ultrasensitive, real-time analysis of biomarkers in breath using tunable external cavity laser and off-axis cavity enhanced absorption spectroscopy," Journal of Biomedical Optics, cilt 20, sayı 3, ss. 037001-8.
- Bayraklı, I., 2015, "External cavity diode lasers-based off-axis cavity enhanced absorption spectroscopy in the spectral range between 1000 nm and 1620 nm for trace-gas measurements," Journal of Near Infrared Spectroscopy, cilt 23, sayı 4, ss. 237–243.
- Bayraklı, I., Öztürk, Ö., Akman, H., 2016, "Investigation of acetone, butanol, and carbon dioxide as new breath biomarkers for convenient and non-invasive diagnosis of obstructive sleep apnea syndrome," Biomedical Chromatography, cilt 30, sayı 12, ss. 1890-1899.
- Bayraklı, I., Türkmen, A., Koçkar, M. C., 2016, “Examination of feasibility of using breath ammonia analysis based on off-axis cavity-enhanced absorption spectroscopy with external cavity diode laser for non-invasive real-time diagnosis of Helicobacter Pylori," Applied Spectroscopy, cilt 70, sayı 8, pp. 1269–1277.
- Bayraklı, I., 2017, "Breath analysis using external cavity diode lasers: a review," Journal of Biomedical Optics, cilt 22, sayı 4, pp. 040901, ss. 1-15.
- Bielecki, Z., et al., 2015, "Application of quantum cascade lasers to trace gas detection," Bulletin of the polish academy of sciences technical sciences, cilt 63, ss. 515–525.
- Huh, J., Yi. B. Gam, D., 1613, Korea Traditional Medicine Book, Seoul, Korea: NaeYi Won.
- Jiang, C., Sun, M., Wang, Z., Chen, Z., Zhao, X., Yuan, Y., Li, Y., Wang, C., 2016, "A Portable Real-Time Ringdown Breath Acetone Analyzer: Toward Potential Diabetic Screening and Management, Sensors, cilt 16, sayı 1199, ss. 1-15.
- Pauling, L., Robinson, A. B., Teranishi, R., Cary, P., 1971, "Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography," Proc. Natl. Acad. Sci. USA, cilt 68, sayı 10, ss. 2374-2376.
- Risby, T. H., Tittel, F. K., 2010, "Current status of mid-infrared quantum and interband cascade lasers for clinical breath analysis," Optical Engineering, cilt 49, sayı 11, ss. 1-15.
- Wang, C., Sahay, P., 2009, "Breath analysis using laser spectroscopic techniques: breath biomarkers, spectral fingerprints, and detection Limits," Sensors, cilt 9, ss. 8230-8262.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Engineering |
| Journal Section | Articles |
| Authors | |
| Publication Date | March 1, 2019 |
| Published in Issue | Year 2019 Volume: 7 Issue: 1 |
