Research Article
BibTex RIS Cite

Investigation of Proton and Sodium Ion Affinities of Topiramate (anticonvulsant drug) by DFT Calculations

Year 2017, Volume: 1 Issue: 2, 1 - 5, 15.12.2017

Hamid Saeidian

Abstract

The
proton and sodium ion affinities of Topiramate has been investigated by DFT
approach. The most basic site for protonation on Topiramate is nitrogen atom of
sulfamate group.  It is also interesting
that sodium ion affinity of Topiramate was determined as 670 kJ mol-1
is less than its proton ion affinity. Because of the limited understanding of the biological
molecular mechanism of Topiramate, these results might devise a clear
understanding of the role of Topiramate in blockade of voltage-dependent sodium
channels in biological systems.

Keywords

Topiramate anticonvulsant drug DFT calculation sodium ion affinity Theoretical chemistry

References

  • [1]. Spina E, Perugi G. Epileptic Disord. 2004;6:57.
  • [2]. Trimble MR, New Anticonvulsants Advances in the Treatment of Epilepsy, Wiley, New York, 1994.
  • [3]. Brodi MJ. Lancet. 1990;336:93.
  • [4]. Saeidian H, Abdoli M, Mirjafary Z. Synthesis. 2015;47:105.
  • [5]. Abdoli M, Saeidian H. J Sulfur Chem. 2015;36:556.
  • [6]. Saeidian, H. Abdoli, M. J Sulfur Chem. 2015;36:463.
  • [7]. Shank R P, Gordoeki JF. J Streter Epilepsia.. 2000;41:53.
  • [8]. Winum JW, Scozzafava A, Montero JL, Supuran KT. Med Res Rev. 2005;25:186.
  • [9]. Shank RP, Gardocki JF, Vaught JL, Davis CB, Schupsky JJ, Raffa RB, Dodgson, SJ, Nortey SO, Maryanoff BE. Epilepsia. 1994;35:450.
  • [10]. Rosenfeld WE. ClinTher. 1997;19:1294.
  • [11]. Zullino DF, Krenz S, Besson J. J Clin Psych. 2003;64:219.
  • [12]. Kwan P, Sills GJ, Brodie MJ. Pharmacol Therapeut. 2001;90;21.
  • [13]. Taverna S, Sancini G, Mantegazza M, Franceschetti S, Avanzini G. J Pharmacol Exp Ther. 1999;88:960.
  • [14]. Cowan J. A, Inorganic Biochemistry: An Introduction, 2th ed., Wiley-VCH, New York, 1997.
  • [15]. Kaim W, Schwederski B. Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life: An Introduction and Guide, Wiley, New York, 1994, p. 267.
  • [16]. Michell AR. The clinical biology of sodium: the physiology and pathophysiology of sodium in mammals, Oxford, UK, 1995, p. 16.
  • [17]. Frisch, MJ. et al. Gaussian, Inc., Wallingford CT, Gaussian 03, Revision E.01, Gaussian, Inc., Pittsburgh PA, 2003.
  • [18]. Ghiasi M, Oskouie A. A, Saeidian H. Carbohyd Res. 2012;348;47.
  • [19]. Ghiasi M, Kamalinahad S, Arabieh M, Zahedi M. Carbohydrate Res. 2012;992;59.
  • [20]. Shakourian-Fard M, Fattahi A, Jamshidi Z. J Phys Org Chem. 2012;25;153.

Year 2017, Volume: 1 Issue: 2, 1 - 5, 15.12.2017

Hamid Saeidian

Abstract

References

  • [1]. Spina E, Perugi G. Epileptic Disord. 2004;6:57.
  • [2]. Trimble MR, New Anticonvulsants Advances in the Treatment of Epilepsy, Wiley, New York, 1994.
  • [3]. Brodi MJ. Lancet. 1990;336:93.
  • [4]. Saeidian H, Abdoli M, Mirjafary Z. Synthesis. 2015;47:105.
  • [5]. Abdoli M, Saeidian H. J Sulfur Chem. 2015;36:556.
  • [6]. Saeidian, H. Abdoli, M. J Sulfur Chem. 2015;36:463.
  • [7]. Shank R P, Gordoeki JF. J Streter Epilepsia.. 2000;41:53.
  • [8]. Winum JW, Scozzafava A, Montero JL, Supuran KT. Med Res Rev. 2005;25:186.
  • [9]. Shank RP, Gardocki JF, Vaught JL, Davis CB, Schupsky JJ, Raffa RB, Dodgson, SJ, Nortey SO, Maryanoff BE. Epilepsia. 1994;35:450.
  • [10]. Rosenfeld WE. ClinTher. 1997;19:1294.
  • [11]. Zullino DF, Krenz S, Besson J. J Clin Psych. 2003;64:219.
  • [12]. Kwan P, Sills GJ, Brodie MJ. Pharmacol Therapeut. 2001;90;21.
  • [13]. Taverna S, Sancini G, Mantegazza M, Franceschetti S, Avanzini G. J Pharmacol Exp Ther. 1999;88:960.
  • [14]. Cowan J. A, Inorganic Biochemistry: An Introduction, 2th ed., Wiley-VCH, New York, 1997.
  • [15]. Kaim W, Schwederski B. Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life: An Introduction and Guide, Wiley, New York, 1994, p. 267.
  • [16]. Michell AR. The clinical biology of sodium: the physiology and pathophysiology of sodium in mammals, Oxford, UK, 1995, p. 16.
  • [17]. Frisch, MJ. et al. Gaussian, Inc., Wallingford CT, Gaussian 03, Revision E.01, Gaussian, Inc., Pittsburgh PA, 2003.
  • [18]. Ghiasi M, Oskouie A. A, Saeidian H. Carbohyd Res. 2012;348;47.
  • [19]. Ghiasi M, Kamalinahad S, Arabieh M, Zahedi M. Carbohydrate Res. 2012;992;59.
  • [20]. Shakourian-Fard M, Fattahi A, Jamshidi Z. J Phys Org Chem. 2012;25;153.
There are 20 citations in total.

Details

Primary Language English
Subjects Chemical Engineering
Journal Section Research Article
Authors

Hamid Saeidian

Publication Date December 15, 2017
Submission Date May 14, 2017
Published in Issue Year 2017 Volume: 1 Issue: 2

Cite

APA Saeidian, H. (2017). Investigation of Proton and Sodium Ion Affinities of Topiramate (anticonvulsant drug) by DFT Calculations. Turkish Computational and Theoretical Chemistry, 1(2), 1-5.
AMA Saeidian H. Investigation of Proton and Sodium Ion Affinities of Topiramate (anticonvulsant drug) by DFT Calculations. Turkish Comp Theo Chem (TC&TC). December 2017;1(2):1-5.
Chicago Saeidian, Hamid. “Investigation of Proton and Sodium Ion Affinities of Topiramate (anticonvulsant Drug) by DFT Calculations”. Turkish Computational and Theoretical Chemistry 1, no. 2 (December 2017): 1-5.
EndNote Saeidian H (December 1, 2017) Investigation of Proton and Sodium Ion Affinities of Topiramate (anticonvulsant drug) by DFT Calculations. Turkish Computational and Theoretical Chemistry 1 2 1–5.
IEEE H. Saeidian, “Investigation of Proton and Sodium Ion Affinities of Topiramate (anticonvulsant drug) by DFT Calculations”, Turkish Comp Theo Chem (TC&TC), vol. 1, no. 2, pp. 1–5, 2017.
ISNAD Saeidian, Hamid. “Investigation of Proton and Sodium Ion Affinities of Topiramate (anticonvulsant Drug) by DFT Calculations”. Turkish Computational and Theoretical Chemistry 1/2 (December 2017), 1-5.
JAMA Saeidian H. Investigation of Proton and Sodium Ion Affinities of Topiramate (anticonvulsant drug) by DFT Calculations. Turkish Comp Theo Chem (TC&TC). 2017;1:1–5.
MLA Saeidian, Hamid. “Investigation of Proton and Sodium Ion Affinities of Topiramate (anticonvulsant Drug) by DFT Calculations”. Turkish Computational and Theoretical Chemistry, vol. 1, no. 2, 2017, pp. 1-5.
Vancouver Saeidian H. Investigation of Proton and Sodium Ion Affinities of Topiramate (anticonvulsant drug) by DFT Calculations. Turkish Comp Theo Chem (TC&TC). 2017;1(2):1-5.
 Download Cover Image

Journal Full Title: Turkish Computational and Theoretical Chemistry


Journal Abbreviated Title: Turkish Comp Theo Chem (TC&TC)