Frequency of Low Immunglobuline level in Pre-School Recurrent Wheezing

Abstract

Objective: Immunoglobulin lowering may be associated with recurrent wheezing symptoms and clinic by increasing the tendency to viral respiratory tract infections. This study aimed to investigate the frequency of immunoglobulinemia in preschoolers with wheezing. Material and Methods: The study was conducted between 01.01.2013 - 01.01.2016 between T.C. University of Health Sciences, Ankara Child Health and Diseases Hematology Oncology Training, and Research Hospital, The Pediatric Allergy and Immunology Clinic included patients who had been followed up and treated for at least one year with recurrent wheezing attacks within 72 months. The patients’ immunoglobulin (G, A, M) values were retrospectively analyzed. Immunoglobulin levels were determined to be normal and low according to age limits. Results: The study included 585 patients (65.6% male, 34.4% female) under the age of 6 years with a mean age of 26.9 months. The mean follow-up period of the patients is 2.2 years. In 33.7% of these patients, at least one immunoglobulin was low. None of these patients had any signs or symptoms of immunodeficiency. Immunoglobulin A was low in 21% of the patients, immünglobulin G in 18%, and immünglobulin M in 7.5% of all patients. Conclusion: Hypogammaglobulinemia was found in approximately 1/3 of the patients. There were no signs of immunodeficiency in these patients. Whether this is a special group in preschooler recurrent wheezing and hypogammaglobulinemia combination should be etiologically investigated.

Keywords

• pre-school recurrent wheezing
• low immunoglobulin
• immunoglobulin M
• immunoglobulin A
• immunoglobulin G

Okul Öncesi Tekrarlayan Vizing ile İzlenen Hastalarda İmmünglobulin Düşüklüğü Sıklığı

Abstract

Amaç: İmmünglobulin düşüklüğü viral solunum yolu enfeksiyonlarına eğilimi arttırarak tekrarlayan vizing semptomları ve kliniği ile ilişki olabilir. Bu çalışmada okul öncesi vizingli hastalarda immünglobulin düşüklüğü sıklığını araştırmak amaçlandı. Gereç ve Yöntemler: Çalışmaya 01.01.2013 - 01.01.2016 tarihleri arasında T.C. Sağlık Bilimleri Üniversitesi Ankara Çocuk Sağlığı ve Hastalıkları Hematoloji Onkoloji Eğitim ve Araştırma Hastanesi Çocuk Allerji ve İmmünoloji Kliniği’nde 72 ay altında tekrarlayan vizing ataklarıyla en az bir yıldır takip ve tedavi edilen hastalar dahil edildi. Hastaların immünglobulin (G,A,M) değerleri geriye dönük olarak incelendi. İmmünglobulin düzeyleri yaş sınırlarına göre normal ve düşük olarak belirlendi. Bulgular: Çalışmada ortalama başvuru yaşı 26.9 ay olan 6 yaş altı 585 (%65.6 erkek, %34.4 kız) hasta dahil edilmiştir. Hastaların ortalama takip süresi 2.2 yıldır. Bu hastaların %33.7 sinde en az bir immünglobulinde düşüklük saptanmıştır. Bu hastaların hiçbirinde immün yetmezlik düşündürecek semptom ve bulgular saptanmamıştır. Tüm hastaların %21’inde immünglobulin A, %18’inde immünglobulin G, %7.5’inde immünglobulin M değerlerinde düşüklük olduğu saptanmıştır. Sonuç: Hastaların yaklaşık 1/3’ünde hipogamaglobulinemi saptandı. Bu hastalarda immün yetmezlik belirtileri yoktu. Okul öncesi tekrarlayan hışıltı ve hipogamaglobulinemi kombinasyonu saptanan hastaların özel bir grup olup olmadığı konusunda araştırmalar yapılmalıdır.

Keywords

• okul öncesi tekrarlayan vizing
• düşük immunglobulin
• immunglobulin G
• immunglobulin M
• immunglobulin A

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