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Pulmoner Fibrozis Gelişen Bir Çocukta Nintedanib Deneyimi

Year 2024, , 71 - 74, 10.01.2024
https://doi.org/10.12956/tchd.1324744

Abstract

Çocuklarda pulmoner fibrozis (PF) çok nadir görülen, ilerleyici ve yaşamı tehdit eden bir durumdur. Nintedanib gibi antifibrotiklerin onaylanmasıyla erişkinlerde idiyopatik PF tedavisinde ilerlemeler kaydedilmiştir. Bununla birlikte, çocuklarda PF tedavisi hala daha fazla çalışılması gereken sonuçsuz bir alandır. Burada, PF'li bir çocukta nintedanib deneyimini sunuyoruz.

References

  • Adamson I. Drug-induced pulmonary fibrosis. Environ. Health Perspect 1984;55:25-36.
  • Bennett JM, Reich SD. Drugs five years later: bleomycin. Ann Intern Med 1979;90:945-8.
  • Reinert T, Baldotto CSdR, Nunes FAP, Scheliga AAdS. Bleomycin-induced lung injury. J. Cancer Res 2013;2013:1-9.
  • Braun S, Ferner M, Kronfeld K, Griese M. Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases. Pediatr Pulmonol 2015;50:410-9.
  • Deterding R, Young LR, DeBoer EM, Warburton D, Cunningham S, Schwerk N, et al. Nintedanib in children and adolescents with fibrosing interstitial lung diseases. Eur Respir J 2023;61:2201512
  • https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205832Orig1s000TOC.cfm.
  • Abid SH, Malhotra V, Perry MC. Radiation-induced and chemotherapy-induced pulmonary injury. Curr Opin Oncol 2001;13:242-8.
  • Eigen H, Wyszomierski D. Bleomycin lung injury in children. Pathophysiology and guidelines for management. Am. J Pediatric Hematol Oncol 1985;7:71-8.
  • Cooper Jr JAD, White DA, Matthay RA. Drug-induced pulmonary disease: Part 1: Cytotoxic drugs. Am Rev Respir Dis 1986;133:321-40.
  • Graves PR, Siddiqui F, Anscher MS, Movsas B. Radiation pulmonary toxicity: from mechanisms to management. Semin Radiat Oncol 2010;20:201-7.
  • Nathan N, Sileo C, Thouvenin G, Berdah L, Delestrain C, Manali E, et al. Pulmonary fibrosis in children. J Clin Med 2019;8:1312.
  • Fyfe A, McKay P. Toxicities associated with bleomycin. JR Coll Physicians Edinb 2010;40:213-5.
  • Banakh I, Lam A, Tiruvoipati R, Carney I, Botha J. Imatinib for bleomycin induced pulmonary toxicity: a case report and evidence‐base review. Clin Case Rep 2016;4:486-90.
  • Sakamoto K, Ito S, Hashimoto N, Hasegawa Y. Pirfenidone as salvage treatment for refractory bleomycin-induced lung injury: a case report of seminoma. BMC cancer 2017;17:1-4.
  • Gundogan BD, Taskinlar S, Arikoglu T, Balci Y, Citak EC. Bleomycin-induced Pneumonitis in a Child Treated With Nintedanib: Report of the First Case in a Childhood. J Pediatr. Hematol Oncol 2022;44:500-2.

Nintedanib Treatment in a Child with Pulmonary Fibrosis

Year 2024, , 71 - 74, 10.01.2024
https://doi.org/10.12956/tchd.1324744

Abstract

Pulmonary fibrosis (PF) in children is a very rare, progressive, and life-threatening condition. There are advances in the treatment of idiopathic PF in adults with the approval of antifibrotics like nintedanib. However, PF treatment in children is still an inconclusive area that needs to be studied further. Here, we present the nintedanib experience in a child with PF.

References

  • Adamson I. Drug-induced pulmonary fibrosis. Environ. Health Perspect 1984;55:25-36.
  • Bennett JM, Reich SD. Drugs five years later: bleomycin. Ann Intern Med 1979;90:945-8.
  • Reinert T, Baldotto CSdR, Nunes FAP, Scheliga AAdS. Bleomycin-induced lung injury. J. Cancer Res 2013;2013:1-9.
  • Braun S, Ferner M, Kronfeld K, Griese M. Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases. Pediatr Pulmonol 2015;50:410-9.
  • Deterding R, Young LR, DeBoer EM, Warburton D, Cunningham S, Schwerk N, et al. Nintedanib in children and adolescents with fibrosing interstitial lung diseases. Eur Respir J 2023;61:2201512
  • https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/205832Orig1s000TOC.cfm.
  • Abid SH, Malhotra V, Perry MC. Radiation-induced and chemotherapy-induced pulmonary injury. Curr Opin Oncol 2001;13:242-8.
  • Eigen H, Wyszomierski D. Bleomycin lung injury in children. Pathophysiology and guidelines for management. Am. J Pediatric Hematol Oncol 1985;7:71-8.
  • Cooper Jr JAD, White DA, Matthay RA. Drug-induced pulmonary disease: Part 1: Cytotoxic drugs. Am Rev Respir Dis 1986;133:321-40.
  • Graves PR, Siddiqui F, Anscher MS, Movsas B. Radiation pulmonary toxicity: from mechanisms to management. Semin Radiat Oncol 2010;20:201-7.
  • Nathan N, Sileo C, Thouvenin G, Berdah L, Delestrain C, Manali E, et al. Pulmonary fibrosis in children. J Clin Med 2019;8:1312.
  • Fyfe A, McKay P. Toxicities associated with bleomycin. JR Coll Physicians Edinb 2010;40:213-5.
  • Banakh I, Lam A, Tiruvoipati R, Carney I, Botha J. Imatinib for bleomycin induced pulmonary toxicity: a case report and evidence‐base review. Clin Case Rep 2016;4:486-90.
  • Sakamoto K, Ito S, Hashimoto N, Hasegawa Y. Pirfenidone as salvage treatment for refractory bleomycin-induced lung injury: a case report of seminoma. BMC cancer 2017;17:1-4.
  • Gundogan BD, Taskinlar S, Arikoglu T, Balci Y, Citak EC. Bleomycin-induced Pneumonitis in a Child Treated With Nintedanib: Report of the First Case in a Childhood. J Pediatr. Hematol Oncol 2022;44:500-2.
There are 15 citations in total.

Details

Primary Language English
Subjects Clinical Sciences (Other)
Journal Section CASE REPORTS
Authors

Meltem Akgül Erdal 0000-0002-7507-0770

Didem Alboğa 0000-0001-8586-5975

Birce Sunman 0000-0001-9818-8782

Hatice Nursun Özcan 0000-0003-4756-4359

Nagehan Emiralioğlu 0000-0002-1405-8401

Ebru Yalçın 0000-0002-7325-1981

Deniz Doğru 0000-0001-9931-9473

Uğur Özçelik 0000-0003-1587-5216

Nural Kiper 0000-0003-1261-7393

Early Pub Date November 6, 2023
Publication Date January 10, 2024
Submission Date July 9, 2023
Published in Issue Year 2024

Cite

Vancouver Akgül Erdal M, Alboğa D, Sunman B, Özcan HN, Emiralioğlu N, Yalçın E, Doğru D, Özçelik U, Kiper N. Nintedanib Treatment in a Child with Pulmonary Fibrosis. Türkiye Çocuk Hast Derg. 2024;18(1):71-4.

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