The Efficacy of Pre-Treatment Proton Pump Inhibitors in the Eradication of Helicobacter pylori

Abstract

Objective: Proton pump inhibitors significantly reduce Helicobacter pylori colonization and provide recovery in its activity and inflammation. We investigated; the effects of eradication initiated 28 days after proton pump inhibitor treatment and eradication initiated simultaneously with proton pump inhibitor treatment, on treatment success rates of Helicobacter pylori. Material and Methods: The study took place at our tertiary care hospital, where 42 patients in the study group were given oral lansoprazole treatment for 28 days followed by eradication treatment and 41 patients in the control group were given both treatments simultaneously. Eradication success was monitored using Helicobacter pylori polyclonal antigen stool tests. Results: A total of 83 participants, aged between 8 and 18 years, tested positive for Helicobacter pylori. The mean age of the participants was 15.14 ± 2.01 years. The Helicobacter pylori cure rate was found to be 92.9% in the study group and 92.7% in the control group. There were no significant differences observed between the two groups in terms of eradicating Helicobacter pylori (p=0.976). Conclusion: We found no significant differences in Helicobacter pylori treatment success rates with modified proton pump inhibitor usage in children.

Keywords

• Esophagogastroduodenoscopy
• Helicobacter pylori
• Proton pump inhibitors
• Treatment

Helicobacter pylori Eradikasyonunda Tedavi Öncesi Proton Pompa İnhibitörlerinin Etkinliği

Abstract

Amaç: Proton pompa inhibitörleri Helicobacter pylori kolonizasyonunu önemli ölçüde azaltarak aktivitesinde ve inflamasyonda azalma sağlar. Proton pompası inhibitörü tedavisinden 28 gün sonra başlatılan eradikasyonun ve proton pompası inhibitörü tedavisiyle eş zamanlı başlatılan eradikasyonun Helicobacter pylori tedavi başarı oranlarına etkisini araştırdık. Gereç ve Yöntemler: Araştırma, üçüncü basamak tedavi merkezi olan hastanemizde gerçekleştirildi; burada çalışma grubundaki 42 hastaya 28 gün boyunca oral lansoprazol tedavisi ve ardından eradikasyon tedavisi verildi, kontrol grubundaki 41 hastaya ise her iki tedavi aynı anda verildi. Eradikasyon başarısı Helicobacter pylori poliklonal antijen dışkı testi kullanılarak değerlendirildi. Bulgular: Çalışmamıza yaşları 8 ile 18 arasında değişen ve Helicobacter pylori pozitif olan toplam 83 katılımcı dahil edildi. Katılımcıların ortalama yaşı 15.14±2.01’di. Helicobacter pylori iyileşme oranı çalışma grubunda %92.9, kontrol grubunda ise %92.7 olarak bulundu. Helicobacter pylori’nin eradikasyonu açısından iki grup arasında anlamlı bir fark gözlenmedi (p=0.976). Sonuç: Çocuklarda modifiye proton pompa inhibitörü kullanımı ile Helicobacter pylori tedavisi başarı oranlarında anlamlı bir fark bulunamadı.

Keywords

• Özofagogastroduodenoskopi
• Helicobakter pylori
• Proton pompa inhibitörleri
• Tedavi

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