Eozinofili ve Sistemik Semptomların Eşlik Ettiği İlaç Döküntüsü (Dress ) ile Eş Zamanlı Sitomegalovirus Enfeksiyonu: Bir Olgu Sunumu

Abstract

Eozinofili ve sistemik semptomların eşlik ettiği ilaç döküntüsü (DRESS) genellikle antikonvülzanların dahil olduğu birtakım ilaçlara, 3-6 hafta maruz kaldıktan sonra görünen şiddetli çoklu organ aşırı duyarlılık reaksiyonu ile karakterizedir. Birçok çalışmada insan Herpes Virüs 6 (HHV-6) reaktivasyonunun DRESS gelişimine katkıda bulunduğu gösterilmiştir. Bununla birlikte yakın dönemdeki çalışmalarda diğer Herpes virüslerden, Herpes virüs 7 (HHV-7), Ebstein-Barr virüs (EBV) ve Sitomegalovirus (CMV) reaktivasyonunun DRESS gelişimiyle ilişkili olduğu gösterilmiştir. Burada febril konvülsiyon profilaksisi için fenitoin kullanmakta olan 2 yaşında bir kız çocuğunda DRESS gelişimi ve eş zamanlı CMV viral yük varlığı gösterilmiştir.

Keywords

• Sitomegalovirus enfeksiyonu, Eozinofili ve sistemik semptomların eşlik ettiği ilaç döküntüsü, DRESS sendromu, İntravenöz immunoglobulin

Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Concurrent with Cytomegalovirus Infection: A Case Report

Abstract

Drug rash with eosinophilia and systemic symptoms (DRESS) is characterized by a severe multiorgan hypersensitivity reaction that usually appears after a 3–6-week exposure to certain drugs, including anticonvulsants. Many reports have revealed that human herpesvirus 6 (HHV-6) reactivation contributes to the development of DRESS. In addition, recent articles have shown that reactivation of other herpesviruses such as human herpesvirus 7 (HHV-7), Epstein-Barr virus (EBV) and cytomegalovirus (CMV) might be also implicated in development of DRESS. Here we report development of the DRESS syndrome and concurrent presence of CMV viral load in a 2-year-old girl who was on phenytoin prophylaxis for febrile seizure

Keywords

• Cytomegalovirus infection, Drug rash with eosinophilia and systemic symptoms, DRESS syndrome, Intravenous immunoglobulin

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