Çocuklarda Astım Atağında Trombosit Aktivasyonun Değerlendirilmesi

Abstract

Amaç: Astım havayollarının kronik inflamatuvar bir hastalığıdır. Allerjik inflamasyon özellikle mast hücreler, eozinofiller, T lenfositler ve trombositlerin toplanmasıyla karakterizedir. Astımlı çocuklarda atak anında ve ataktan en az 1 ay sonraki dönemde ortalama trombosit hacmi (MPV), trombosit dağılım aralığı (PDW), plateletcrit ve p-selektin düzeylerindeki değişimlerin belirlenerek atak sırasında bir belirteç olarak kullanılabilirliğinin olup olmadığını araştırdık.Gereç ve Yöntemler: Çalışmaya astım atağındaki 40 çocuk alındı. Hastalardan atak anında ve ataktan en az 1 ay sonra MPV, PDW, PCT, p-selektin, eozinofil ve trombosit sayılarını değerlendirmek için kan örnekleri alındı.Bulgular: Atak anındaki MPV, PCT ve p-selektin düzeyleri ataktan bir ay sonrası ile karşılaştırıldığında daha düşük bulundu.Sonuç: Bulgularımız rutin pratikte sık kullanılan parametreler olan MPV ve PCT değerlerinin astım atağını belirlemede kullanılabileceğini göstermiştir.

Keywords

• Astım, Ortalama trombosit hacmi (MPV), Trombosit dağılım aralığı (PDW), Plateletcrit, P-selektin

Evaluation of Platelet Activation During an Asthmatic Attack in Children

Abstract

Objective: Asthma is a chronic inflammatory disease of the airways. Allergic inflammation is characterized by accumulation of various cells, particularly mast cells, eosinophils, T lymphocytes and platelets. We investigated whether changes in mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) and p-selectin levels of children with asthma during and at least 1 month after the attack can be used as a marker.Material and Methods: The study was performed in 40 children who suffered asthma attacks. Blood samples were taken for MPV, PDW, PCT, p-selectin, eosinophil and platelet values during and at least 1 month after the attack. Results: Mean platelet volume, PCT, and p-selectin levels were significantly lower at the time of the attack when compared to those at least 1 month after the attack. Conclusion: Our findings suggest that MPV and PCT, common parameters in routine practice, can be used to determine an asthma attack

Keywords

• Asthma, Mean platelet volume (MPV), Platelet distribution width (PDW), Plateletcrit (PCT), P-selectin

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