Endokrin Polikliniğimize Başvuran Obez Çocuklarda Metabolik Sendrom Sıklığı

Abstract

Giriş ve Amaç: Polikliniğimize başvuran obez çocuk ve adölesanlarda metabolik sendrom (MS) sıklığının araştırılmasıdır.Gereç ve Yöntemler: Ekzojen obezite tanısı alan ve oral glukoz tolerans testi uygulanan 6-18 yaş arası 92 çocuk ve adölesan çalışmaya alındı. Hastaların dosyaları retrospektif olarak incelendi. NCEP/ATP III ve DSÖ tarafından erişkinler için tanımlanan MS kriterleri çocukluk çağı referans değerleri ile değiştirildi. Üç veya daha fazla kriter taşıyanlar MS olarak kabul edildi.Bulgular: 30 (%32) hastada MS tespit edildi. MS’i olanların 18’inde insülin rezistansı (IR), altısında bozulmuş açlık glukozu, dokuzunda bozulmuş glukoz intoleransı, ikisinde diyabet vardı. Dislipidemisi olan 27 MS’li hastanın 12’sinde hipertrigliseridemi, ikisinde HDL-C düşüklüğü, dokuzunda hipertrigliseridemi ve HDL-C düşüklüğü, üçünde hipertrigliseridemi ve LDL-C yüksekliği, birinde sadece LDL-C yüksekliği saptandı. 12 hastada sistolik, 10 hastada diyastolik hipertansiyon vardı. 21 MS’li hastanın 10’unda USG ile hepatosteatoz saptandı.Sonuç: Obez çocuk ve adölesanlarda MS sıklığı oldukça yüksektir. Bu hastalar ileride diyabet ve kardiyovasküler hastalık gelişimi açısından hipertansiyon, dislipidemi, IR ve/veya diyabet gibi birden fazla risk faktörü taşımaktadırlar.

Keywords

• Dislipidemi, İnsülin rezistansı, Metabolik sendrom, Obezite

Prevalence of Metabolic Syndrome in Obese Children who Presented at Our Endocrinology Clinic

Abstract

Objective: To investigate the prevalence of the metabolic syndrome in obese children and adolescents who presented at our endocrine clinic.Material and Methods: We included 92 children and adolescents between the ages of 6-18 who underwent a standard dose of oral glucose tolerance test with a diagnosis of exogenous obesity. Their medical records were analyzed retrospectively. We modified the criteria of metabolic syndrome (MS) for adults defined by the NCEP/ATP III and WHO with the pediatric age reference values. MS was diagnosed in those with three or more criteria.Results: 30 (32%) patients were diagnosed with MS. Among these patients with MS, we determined insulin resistance (IR) in 18, impaired fasting glucose in 6, impaired glucose tolerance in 9 and diabetes in 2 patients. Hypertriglyceridemia was found in 12 of 27 dyslipidemic MS patients, low HDL-C in two, hypertriglyceridemia and low HDL-C in nine, and hypertriglyceridemia and LDL-C elevation in three patients. LDL-C elevation was detected only in one patient. There was systolic hypertension in 12 patients. Ten patients had diastolic hypertension. Hepatosteatosis was determined by USG in 10 of 21 patients with MS.conclusion: Obese children have a high prevalence of MS. These patients possess multiple risk factors for the development of diabetes and cardiovascular disease in the future such as hypertension, dyslipidemia and insulin resistance

Keywords

• Dyslipidemia, Insulin resistance, Metabolic syndrome, Obesity

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