Akut Lösemili Çocuklarda Febril Nötropeni Ataklarının Değerlendirilmesi

Abstract

Bu çalışmada 75 lösemili çocukta gelişen 221 febril nötropeni (FN) atağı retrospektif olarak incelenerek ampirik antibiyoterapi özellikleri, antibiyotik modifikasyonları, kültür sonuçları, tedavi süreleri ve mortaliteleri değerlendirildi. Mikrobiyolojik ve/veya klinik olarak kanıtlanmış enfeksiyon, 117 (%52.9) atakta saptandı. Kan kültüründe mikroorganizma izole edilme oranı %14.4 idi. Bunlardan %73.5’u gram pozitif, %17.6’sı gram negatif ve %8.8’i de fungal patojenlerdi. Ateşin kontrol altına alınma süresi ortalama 7.2 gün ve antibiyotik kullanma süresi ortalama 13 gün idi. Hastalarımızda, granülosit-koloni stimüle edici faktör (G-CSF) 102 FN atağında (%46.2) kullanıldı. Febril nötropeni atağı sırasında sekiz hasta (%3.6) kaybedildi.

Keywords

• Febril nötropeni, çocuk, akut lösemi

EVALUATION OF FEBRILE NEUTROPENIA IN CHILDREN WITH ACUTE LEUKEMIA

Abstract

In this retrospective study, we evaluated 221 febrile neutropenia (FN) episodes in 75 pediatric leukemia cases during empiric antibiotherapy in terms of antibiotic modifications, culture results, treatment period and mortality retrospectively. One hundred and seventeen (52.9%) episodes were microbiologically and/or clinically documented infections. During febrile neutropenia attacks, 14.4% of patients had bacteriemia. Of isolated microorganisms, 73.5% gram-positive, 17.6% were gram-negative and 8.8% fungal pathogens. Fever resolved after mean 7.2 days and mean antibiotic administration time was 13 days. Granulocyte-colony stimulating factor (G-CSF) was used in 102 episodes (46.2%) of FN. Eight patients (%3.6) died during a FN episode

Keywords

• Febrile neutropenia, children, acute leukemia

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