NEONATAL AUTOIMMUNE THROMBOCYTOPENIA DUE TO MATERNAL IMMUNE THROMBOCYTOPENIC PURPURA: REPORT OF THREE CASES

Abstract

The overall frequency of thrombocytopenia in infants born to mothers with ITP is quite low, and about 1-5% of infants will have platelet count less than 20 000/ µL at birth, and about 1% will have significant bleeding complications. Three infants with severe thrombocytopenia born to mothers with ITP are described in this report. The infants were born from two pregnancies. Two of the infants were twins, and were born to a mother with ITP diagnosed at 22nd weeks of gestation. Their cord blood platelet counts were 6600/µL, and 31900/µL, respectively. The third infant was born to a mother with chronic ITP. The lowest platelet count was 20600/µL at postnatal day five. All infants received intravenous immunoglobulin therapy and one of them received platelet suspension infusion. Although neonatal thrombocytopenia associated with ITP is generally moderate or mild, it is important to note that some infants will have severe thrombocytopenia for several days following delivery

Keywords

• Neonatal Thrombocytopenia, IVIG, ITP

İmmün Trombositopenik Purpuralı Anne Bebeklerinde Trombositopeni: Üç Olgu Sunumu

Abstract

ITP tanılı annelerden doğan bebeklerde trombositopeni sıklığı oldukça düşüktür. Trombosit sayısının 20000 / μL ‘den az olma ihtimali % 1-5 arasındadır ve yaklaşık % 1’inde önemli derecede kanama komplikasyonu gelişir. Bu raporda, iki ITP’li anneden doğan üç bebek tanımlandı. İkizler 22. gebelik haftasında ITP tanısı alan anneden doğdular. Kordon kanı trombosit değerleri sırasıyla 6600/μL ve 31900/μL olarak tespit edildi. Üçüncü bebek kronik ITP’li anneden doğdu. Bu bebekte en düşük trombosit değeri beşinci günde 20600/μL olarak tespit edildi. Tüm bebekler intravenöz immunoglobulin alırken bir bebek trombosit süspansiyonu aldı. ITP ile ilişkili yenidoğan trombositopenisi genellikle hafif ve orta şiddette olmasına rağmen bazı yenidoğanlarda doğumu takip eden günlerde ağır trombositopeni gelişebilir.

Keywords

• Yenidoğan Trombositopenisi, IVIG, ITP

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