Fetal Programlanma

Abstract

Hamilelikte annenin beslenmesi fetal beslenme durumunu da belirler. Fetal beslenme yetersizliği varsa, fetüs yaşama şansını artırabilmek için vasküler, metabolik ve endokrin adaptasyonlar geliştirir. Bu adaptasyonlar erişkin dönemde de vücutta kalıcı yapı ve fonksiyon değişikliklerine yol açmakta, buna eklenen erişkin – yaşam risk faktörleri ile hipertansiyon, tip 2 diyabet, obezite ve hiperkolesterolemi riskini artırmaktadır. “Fetal programlanma” hipotezi hamilelikte ekzojen maternal malnütrisyonun fetüste yaşam boyu devam eden bir adaptasyona (insülin direncine) sebep olduğunu öne sürmektedir. Ayrıca bazı maternal genlerin, örneğin G protein β3 subünitesinin fetal malnütrisyona katkıda bulunabileceği ve bu adaptasyonu indükleyebileceği ileri sürülmüştür. Bu yazıda fetal programlanma ve bunu değiştirebilecek şartlar ile ilgili güncel bilgiler literatür ışığında derlendi.

Keywords

• İntrauterin büyüme geriliği, fetal programlanma

FETAL PROGRAMMING

Abstract

Maternal nutrition during pregnancy determines fetal nutrition. Impaired fetal nutrition causes an adaptation which improves the chance for survival of the fetus. These adaptations may be vascular, metabolic or endocrine. They permanently change the function and the structure of the body in adult life. In combination with adverse adult-life risk factors, these persisting fetal adaptations causing low-birth-weight increase the risk for adult diseases such as hypertension, insulin, resistance and hypercholesterolemia according to “ fetal programming” hypothesis. In addition, beside maternal malnutrition during pregnancy, maternal genes such as G protein β3 subunit allele may contribute to fetal malnutrition and therefore induce these adaptations of the fetus which causes cardiovascular disease in adult life. This review gives the current knowledge about fetal programming and its manipulation in the highlight of the literature

Keywords

• Intrauterine growth retardation, fetal programming

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