Açıklanamayan Transaminaz Yüksekliği ve Atipik Çölyak Hastalığı: Olgu Sunumu

Abstract

Çölyak hastalığı transaminaz yüksekliğinin önemli nedenlerinden birisidir. Açıklanamayan transaminaz yüksekliği olan hastaların % 9'unda çölyak hastalığı saptandığı bildirilmiştir. Başka bir bulgusu olmaksızın 6 aydır devam eden transaminaz yüksekliği nedeniyle tetkik edilirken çölyak hastalığı tanısı alan ve glutensiz diyet başlandıktan 6 ay sonra transaminaz yüksekliği normale dönen, bir çocuk hasta sunulmuştur.

Keywords

• Çölyak hastalığı, transaminaz yüksekliği, çocuk

UNEXPLAINED ELEVATION OF SERUM TRANSAMINASE LEVEL AND ATYPICAL CELIAC DISEASE: A CASE REPORT

Abstract

Celiac disease is an important cause of hypertransaminasemia. Celiac disease has been reported in 9 % of patients with unexplained hypertransaminasemia. We report a child who presented with elevated serum transaminase activity, and diagnosed as celiac disease after exclusion of other causes of chronic hypretransaminasemia. Hypertransaminasemia improved after 6 months of gluten free diet

Keywords

• Celiac disease, elevated transaminase level, children

References

1. Farre C, Esteve M, Curcoy A, Cabre E, Arranz E, Amat LL, Garcia- Tornel S. Hypertransaminasemia in pediatric coeliac disease and its prevalance as a diagnostic clue. Am J Gastroenterol 2002;97:3176-3181.
2. Ludvigsson JF, Elfström P, Broome U, Ekbom A, Montgomery SM. Celiac disease and risk of liver disease: a general population-based study. Clin Gastroenterol Hepatol 2007;5:63-69.
3. Kaukinen K, Hamle L, Collin P, Farkkıla M, Maki M, Vehmanen P, Partanen J, Höckerstedt K. Celiac disease in patients with severe liver disease: gluten free diet may reverse hepatic failure. Gastroenterology 2002;122:881-888.
4. Volta U, de Franceschi L, Molinaro N, Cassani F, Muratori L, Lenzi M, Bianchi FB, Czaja AJ. Frequency and significance antigliadin and antiendomysial antibodies in autoimmune hepatitis. Dig Dis Sci 1998;43:2190-2195.
5. Jacobsen MB, Fausa O, Elgjo K, Schrumpf E. Hepatic lesions in adult coeliac disease. Scand J Gastroenterol 1990;25:656-662.
6. Greco L, Auricchio S, Mayer M, Grimaldi M. Case-control study on nutritional risk factors in celiac disease. J Pediatr Gatroenterol Nutr 1988;7:395-399.
7. Peters U, Schneeweiss S, Trautwein EA, Erbersdobler HF. A case- control study of the effcet of infant feeding on coeliac disese. Ann Nutr Metab 2001;45:135-142.
8. Auricchio S, Follo D, de Ritis G, Giunta A, Marzorati D, Prampolini L, Ansaldi N, Levi P, Dall'olio D, Bossi A, et all. Does brestfeeding protect against the development of clinical symptoms of coeliac disease in children. J Pediatr Gastroenterol Nutr 1983;2:428-433.

9. Falth-Magnusson K, Franzen L, Jansson G, Laurin P, Stenhammar L. Infant feeding history shows distinct differences between Swedish celiac and reference children. Pediatr Allergy Immunol 1996;7:1-5.
10. Ascher H, Krantz I, Rydberg L, Nordin P, Kristiansson. Influence of infant feeding and gluten intake on coeliac disease. Arch Dis Child 1997;76:113-117.
11. Akobeng AK, Ramanan AV, Buchan I, Heller RF. Effect of breastfeeding on coeliac disease: a sytematic review and meta-analysis of observational study. Arch Dis Child 2006;91:39-43.
12. Novacek G, Miehsler W, Wrba F, Ferenci P, Penner E, Vogelsang H.
13. Arslan N, Büyükgebiz B, Öztürk Y, Özer E. The prevalance of liver function abnormalities in pediatric celiac disease patients and its relation with intestinal biopsy findings. Acta Gastroenterol Belg 2005;68:424-427.