Case Report

Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection

Volume: 12 Number: 4 December 30, 2018
Türkiye Çocuk Hastalıkları Dergisi Cover
Türkiye Çocuk Hastalıkları Dergisi
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Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection

Abstract

Subcutaneous interferon beta 1a (IFN β 1a) has been shown to reduce relapse rates in patients with relapsing-remitting

multiple sclerosis. We report the occurrence of severe necrotizing cutaneous reactions in a 19-year-old girl. She self

injected IFN β 1a three times a week on the abdomen and both thighs. Treatment was initially well tolerated, but she

described erythematous patches and local pain at the injection sites recently. The areas on the abdomen became

violaceous with necrotic ulcers. Her therapy was changed to 0.5 mg fingolimod. The lesions began to improve and

cicatrize after several weeks with postinflammatory hyperpigmentation. Early recognition of severe local adverse

reactions and correction of the injection technique is important.

Keywords

References

  1. 1. PRISMS (Prevention of Relapses and Disability by Interferon betala Subcutaneously in Multiple sclerosis) Study Group. Randomized double-blind placebo-controlled study of interferon beta-la in relapsing-remitting multiple sclerosis. Lancet 1998;352:1498-504.
  2. 2. Elgart GW, Sheremata W, Ahn YS. Cutaneous reactions to recombinant human interferon beta 1b: The clinical and histologic spectrum. J Am Acad Dermatol 1997;37:5538.
  3. 3. Lebrun C, Bertagna M, Cohen M. Cutanous side effects of immunomodulators in MS. Int MS J 2011;17:88-94.
  4. 4. Beer K, Müller M, Hew-Winzeler AM, Bont A, Maire P, You X, et al. The prevalence of injection-site reactions with disease-modifying therapies and their effect on adherence in patients with multiple sclerosis: An observational study. BMC Neurol 2011;11:144.
  5. 5. Sheremata WA, Taylor JR, Elgart GW. Severe necrotizing cutaneous lesions complicating treatment with interferon beta-1b. N Engl J Med 1995;332:1584.

Details

Primary Language

English

Subjects

​Internal Diseases

Journal Section

Case Report

Authors

Publication Date

December 30, 2018

Submission Date

October 6, 2017

Acceptance Date

-

Published in Issue

Year 2018 Volume: 12 Number: 4

DOI

https://doi.org/10.12956/tjpd.2018.336

IZ

https://izlik.org/JA53YA59UC

Cite

RIS / Bibtex
APA
Öz Tunçer, G. (2018). Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection. Türkiye Çocuk Hastalıkları Dergisi, 12(4), 280-282. https://doi.org/10.12956/tjpd.2018.336
AMA
1.Öz Tunçer G. Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection. Turkish J Pediatr Dis. 2018;12(4):280-282. doi:10.12956/tjpd.2018.336
Chicago
Öz Tunçer, Gökçen. 2018. “Cutaneous Ulceration Associated With Subcutaneous Interferon Beta 1a Injection”. Türkiye Çocuk Hastalıkları Dergisi 12 (4): 280-82. https://doi.org/10.12956/tjpd.2018.336.
EndNote
Öz Tunçer G (December 1, 2018) Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection. Türkiye Çocuk Hastalıkları Dergisi 12 4 280–282.
IEEE
[1]G. Öz Tunçer, “Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection”, Turkish J Pediatr Dis, vol. 12, no. 4, pp. 280–282, Dec. 2018, doi: 10.12956/tjpd.2018.336.
ISNAD
Öz Tunçer, Gökçen. “Cutaneous Ulceration Associated With Subcutaneous Interferon Beta 1a Injection”. Türkiye Çocuk Hastalıkları Dergisi 12/4 (December 1, 2018): 280-282. https://doi.org/10.12956/tjpd.2018.336.
JAMA
1.Öz Tunçer G. Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection. Turkish J Pediatr Dis. 2018;12:280–282.
MLA
Öz Tunçer, Gökçen. “Cutaneous Ulceration Associated With Subcutaneous Interferon Beta 1a Injection”. Türkiye Çocuk Hastalıkları Dergisi, vol. 12, no. 4, Dec. 2018, pp. 280-2, doi:10.12956/tjpd.2018.336.
Vancouver
1.Gökçen Öz Tunçer. Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection. Turkish J Pediatr Dis. 2018 Dec. 1;12(4):280-2. doi:10.12956/tjpd.2018.336

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