Evaluation of the Clinical Characteristics of the Girls with Central Precocious Puberty at Diagnosis and During Treatment

Abstract

Aim: It is aimed to evaluate the anthropometric and clinical characteristics of the girls with idiopathic central precocius puberty (CPP) at diagnosis, during and at the end of treatment.  

Materials and methods: Sixty-one girls who were diagnosed with CPP and treated between January 2015 and December 2018 were included in the study. The anthropometric, clinical characteristics and laboratory test results at diagnosis, during and at the end of treatment were retrospectively evaluated.

Results: Mean age of the patients at diagnosis was 8.7±0.6 years, bone age was 10.3±1.3 years, target height was 158.4±5.2 cm and predicted height was 160.1±7.6 cm. While 18 (30%) patients presented with isolated thelarche, 11 (18%) patients presented with menarche. At diagnosis, 28% of the patients were obese and 25% were overweight. The average treatment period was 2 years. The body mass index (BMI) increased during treatment (p<0.001) which was significant especially in the first two years of treatment (p<0.001). In first year of treatment, the ratio of the obese patients had increased to 36%. During treatment, height growth rates were decreased (p=0.02). However, the predicted height at the end of the study was 160.1±6.2 cm and there was no difference when compared to the height at diagnosis (p>0.05).

Conclusion: Obese and overweight girls should be followed up for pubertal development. Awareness level of primary care physicians and pediatricians should be increased in order to identify the early puberty findings and provide appropriate guidance.

Keywords

• Awareness,idiopathic,menarche,obesity,precocious puberty

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