İnfantil Kolikli Bebeklerin Plazma Magnezyum ve Çinko Düzeyleri

Abstract

Amaç: Melatonin sentezinde kofaktör olmaları; Mg eksikliğine bağlı kas krampları, uyku bozuklukları, irritabilite ve Zn eksikliği ile ilişkili uyku ve davranış bozuklukları olması infantil kolikli bebeklerin plazma Mg ve Zn düzeylerinin düşük olabileceğini akla getirmiştir. Bu çalışmada infantil kolikli bebeklerin ve annelerinin plazma Mg ve Zn düzeylerinin kontrollerle karşılaştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu kesitsel çalışmaya infantil kolik tanısı alan 1-3 aylık 50 bebek ve 22 sağlıklı kontrol anneleri ile birlikte dahil edilmiştir. Kolik grubu iki alt gruba ayrılmıştır; (1) Mg içeren bitki çayları verilen bebekler (bitki çayı grubu, n=12), (2) Mg ya da Zn içeren herhangi bir destek verilmeyen bebekler (çalışma grubu, n=27). Plazma Mg ve Zn düzeyleri flame fotometride Atomik Absorbsiyon Spektrofotometresi ile ölçülmüştür. Bulgular: Bebeklerin Mg düzeyleri (mg/dl) açısından çalışma grubu (2.46±0.27) ve kontrol grubu (2.37±0.25) arasında fark yoktu (p=0.70). Bununla birlikte plazma Mg düzeyleri bitki çayı grubunda (2.68±1.90) çalışma (2.46±0.27) ve kontrol grubundan (2.37±0.25) daha yüksekti (sırasıyla p=0.04, p=0.004). Bebeklerin Zn düzeyleri, annelerinin Mg ve Zn düzeyleri gruplar arasında farklı değildi (sırasıyla p=0.36, p=0.61, p=0.22). Bitki çayı grubunda dört aile Mg-içeren bitki çaylarından fayda gördüklerini bildirdi, ancak bebeklerinin Mg düzeyleri Mg-içeren bitki çaylarından fayda görmediğini belirten ailelerinki ile benzer bulundu (p=0.79). Sonuç: Kolikli bebeklerin ve annelerinin plazma Mg ve Zn düzeyleri sağlıklı kontrollerinden farklı değildir. Mg desteğinin kolik şiddeti üzerine etkisinin araştırılması için daha ileri çalışmalara ihtiyaç vardır.

Keywords

• İnfantil kolik,Magnezyum,Çinko

Plasma Magnesium and Zinc Levels in Infants with Infantile Colic

Abstract

Objective:Muscle cramps, sleep disorders, and irritability due to Mg deficiency; and sleep and behavioral disorders associated with Zn deficiency and being cofactors in the melatonin synthesis have suggested that plasma Mg and Zn may be in lower levels in colicky infants. This study aimed to compare plasma Mg and Zn levels of colicky infants and the mothers’ with controls. 

Material and Methods:Fiftyinfants diagnosed with infantile colic and 22 controls aged 1-3 months with their mothers were included in this cross-sectional study. Colic group was divided into two subgroups; (1) infants who were given Mg-contain herbals (herbals-group, n=12), (2) infants who were not given any Mg or Zn-contain supplement (study group, n=27). Plasma Mg and Zn levels were measured by Atomic Absorption Spectrophotometer on flame photometry.

Results: Mg levels (mg/dl) of the infants were not different between study group (2.46±0.27) and controls (2.37±0.25)(p=0.70). However, plasma Mg levels were higher in the herbals-group (2.68±1.90)than the study group(2.46±0.27)and controls (2.37±0.25) (p=0.04, p=0,004; respectively). Zn levels (mg/dl) of the infants and Mg and Zn levels of the mothers were not different between the groups (p=0.36, p=0.61, p=0.22; respectively). Four parents in the herbals-groupreported they get benefit from the Mg-contain herbals, but Mg levels were similar with the parents who do not get benefit (p=0.79). 

Conclusion:Plasma Mg and Zn levels of colicky infants and their mothers’ were not different from healthy controls in this study. Further studies are needed to determine the effect of Mg supplementation on colic severity. 

Keywords

• infantile colic,magnesium,zinc

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