COVID-19’DA SİTOKİN SALINIM SENDROMU VE TEDAVİ YAKLAŞIMLARI

Abstract

Yeni ortaya çıkan coronavirus hastalığı 2019 (COVID-19) küresel bir sağlık sorunudur ve pandemi olarak kabul edilmiştir. COVID-19, hastaların çoğunda hafif grip benzeri semptomlara yol açmasına rağmen, hastalık akut solunum sıkıntısı sendromu ve sitokin salınım sendromu gibi sıklıkla ölümcül, ciddi komplikasyonlara neden olabilir. Bu hastalarda lenfositik sitolitik aktivitedeki defektler proinflamatuar sitokin kaskadını tetiklemekte ve “sitokin fırtınasını” başlatmaktadır. Sonuç olarak, dokulara kontrolsüz aktif makrofaj girişine ve hemofagositoza yol açmaktadır. Burada, COVID-19’da konakçı hücrelerin yanıtları, sitokin salınım sendromu ve sitokin fırtınasını durdurmak için tedavi yaklaşımları ele alınmıştır.

Keywords

• COVID-19
• Sitokin Salınım Sendromu
• Sitokin Fırtınası
• Tocilizumab

CYTOKINE RELEASE SYNDROME AND TREATMENT IN COVID-19

Abstract

The emergent outbreak of coronavirus disease 2019 (COVID-19) is a global health problem and has been recognized as a pandemic. Although COVID-19 leads to mild flu-like symptoms in most patients, the disease may cause frequently fatal, severe complications, such as acute respiratory distress syndrome and cytokine release syndrome. In these patients, defects in lymphocytic cytolytic activity trigger the proinflammatory cytokine cascade, and then “cytokine storm” begins. As a result, it leads to uncontrolled active macrophage entry into the tissues and hemophagocytosis. Here, the responses of host cells, cytokine release syndrome and the therapeutic approaches to alleviate the cytokine storm in COVID-19 will be reviewed.

Keywords

• Cytokine Release Syndrome
• Cytokine Storm
• Tocilizumab
• COVID-19

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