COVID-19’lu Hastalarda Görülen Hematolojik Parametreler

Abstract

SARS-CoV-2 primer olarak solunum yolu enfeksiyonuna neden olmakla birlikte hematopoietik ve immun sistemlerini de etkileyebilmektedir. Enfekte olan hastalarda, lenfositler, nötrofiller, monositler ve trombositlerde kantitatif ve kalitatif değişiklikler bildirilmektedir. Bu değişiklikler ile hastalığın şiddeti arasında ilişki olduğu da gösterilmiştir. Lenfopeni, SARS-CoV-2 ile enfekte erişkin hastalarda en sık görülen bulgu iken çocuklarda çok daha az görülmektedir. Şiddetli enfeksiyonu olan hastalarda lökositoz saptanabilir, hafif-orta şiddette enfeksiyonu olan hastalarda ise lökositoz daha nadirdir. Klinik ile uyumlu olarak trombositopeni veya trombositoz da görülebilmektedir. Hastaların periferik yaymalarında özellikle nötrofil ve trombositlerde displastik morfolojik değişikler saptanabilir.

Keywords

• COVID-19
• Hematology
• lymphocyte
• Thrombocyte
• Neutrophil

Hematologic Parameters of Patients with COVID-19 Infection

Abstract

SARS-CoV-2 causes primarily respiratory tract infection, but can also affect hematopoietic and immune systems. Quantitative and qualitative changes in lymphocytes, neutrophils, monocytes and platelets, are reported in infected patients. These changes are related to the severity of the disease. Lymphopenia is the most common finding in adult patients infected with SARS-CoV-2, while it is much less common in children. Leukocytosis can be detected in patients with severe infection, but rare in patients with mild to moderate infection. Thrombocytopenia or thrombocytosis can also be seen in accordance with the clinic. Dysplastic morphological changes in neutrophils and platelets can be detected in peripheral smear of patients.

Keywords

• COVID-19
• Hematology
• lymphocyte
• Thrombocyte
• Neutrophil

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