Research Article

What Has Changed Over the Last Decade in Systemic Juvenile İdiopathic Arthritis?

Volume: 15 Number: 1 January 22, 2021
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Türkiye Çocuk Hastalıkları Dergisi
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What Has Changed Over the Last Decade in Systemic Juvenile İdiopathic Arthritis?

Abstract

Objective: Systemic juvenile idiopathic arthritis (sJIA) is one of seven subtypes of JIA. The aim of this study was to investigate the characteristics, the course and the outcome of sJIA patients in our clinic and to identify what has changed over the last decade in sJIA.

Material and Methods: Files of sJIA patients that were followed between March 2002 and April 2019 were evaluated.

Results: During the study period 36 patients were diagnosed with sJIA in our clinic (19 were male). Mean age of patients was 81.7±50.1 months at the onset of disease. Most common presenting features were fever (100%), arthritis (83.3%), rash (66.7%) and hepatosplenomegaly (38.9%). Seven patients (19.4%) were diagnosed as macrophage activation syndrome (MAS) due to sJIA. All patients had received corticosteroids. Additional treatments (disease-modifying drugs, intravenous immunoglobulin and biological agents) were given to 29 patients. In our clinic, anti-IL-1 agents have been used since 2011. In this group 26 (72.2%) patients were diagnosed after 2011. After the usage of biological agents, the duration of steroid exposure significantly decreased (p= 0.001).

Conclusion: After the introduction of biological agents in the treatment of sJIA, the duration of steroid exposure decreased significantly. Considering anti interleukin (IL)-1 and anti IL-6 treatments among the priority treatments in sJIA patients is important in terms of both providing rapid disease control and reducing side effects related to drugs.

Keywords

References

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Details

Primary Language

English

Subjects

​Internal Diseases

Journal Section

Research Article

Authors

Nilüfer Tekgöz This is me
0000-0002-2235-4489
Türkiye

Publication Date

January 22, 2021

Submission Date

October 8, 2020

Acceptance Date

November 24, 2020

Published in Issue

Year 2021 Volume: 15 Number: 1

DOI

https://doi.org/10.12956/tchd.807572

IZ

https://izlik.org/JA72NT45WM

Cite

RIS / Bibtex
APA
Aydın, F., Kurt, T., Tekgöz, N., Sezer, M., Başaran, Ö., Çakar, N., & Acar, B. (2021). What Has Changed Over the Last Decade in Systemic Juvenile İdiopathic Arthritis? Türkiye Çocuk Hastalıkları Dergisi, 15(1), 65-71. https://doi.org/10.12956/tchd.807572
AMA
1.Aydın F, Kurt T, Tekgöz N, et al. What Has Changed Over the Last Decade in Systemic Juvenile İdiopathic Arthritis? Turkish J Pediatr Dis. 2021;15(1):65-71. doi:10.12956/tchd.807572
Chicago
Aydın, Fatma, Tuba Kurt, Nilüfer Tekgöz, et al. 2021. “What Has Changed Over the Last Decade in Systemic Juvenile İdiopathic Arthritis?”. Türkiye Çocuk Hastalıkları Dergisi 15 (1): 65-71. https://doi.org/10.12956/tchd.807572.
EndNote
Aydın F, Kurt T, Tekgöz N, Sezer M, Başaran Ö, Çakar N, Acar B (January 1, 2021) What Has Changed Over the Last Decade in Systemic Juvenile İdiopathic Arthritis? Türkiye Çocuk Hastalıkları Dergisi 15 1 65–71.
IEEE
[1]F. Aydın et al., “What Has Changed Over the Last Decade in Systemic Juvenile İdiopathic Arthritis?”, Turkish J Pediatr Dis, vol. 15, no. 1, pp. 65–71, Jan. 2021, doi: 10.12956/tchd.807572.
ISNAD
Aydın, Fatma - Kurt, Tuba - Tekgöz, Nilüfer - Sezer, Müge - Başaran, Özge - Çakar, Nilgün - Acar, Banu. “What Has Changed Over the Last Decade in Systemic Juvenile İdiopathic Arthritis?”. Türkiye Çocuk Hastalıkları Dergisi 15/1 (January 1, 2021): 65-71. https://doi.org/10.12956/tchd.807572.
JAMA
1.Aydın F, Kurt T, Tekgöz N, Sezer M, Başaran Ö, Çakar N, Acar B. What Has Changed Over the Last Decade in Systemic Juvenile İdiopathic Arthritis? Turkish J Pediatr Dis. 2021;15:65–71.
MLA
Aydın, Fatma, et al. “What Has Changed Over the Last Decade in Systemic Juvenile İdiopathic Arthritis?”. Türkiye Çocuk Hastalıkları Dergisi, vol. 15, no. 1, Jan. 2021, pp. 65-71, doi:10.12956/tchd.807572.
Vancouver
1.Fatma Aydın, Tuba Kurt, Nilüfer Tekgöz, Müge Sezer, Özge Başaran, Nilgün Çakar, Banu Acar. What Has Changed Over the Last Decade in Systemic Juvenile İdiopathic Arthritis? Turkish J Pediatr Dis. 2021 Jan. 1;15(1):65-71. doi:10.12956/tchd.807572

Cited By

Treatment of systemic juvenile idiopathic arthritis: conventional treatment versus biologics

The Turkish Journal of Pediatrics

https://doi.org/10.24953/turkjpediatr.2025.5482


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