Can Uric Acid Be A Marker For Metabolically Unhealthy Obesity in Children and Adolescents?

Abstract

Aim: In this study it was investigated whether there is a difference between metabolically healthy (MHO) and unhealthy (MUO) obese children regarding laboratory results, especially serum uric acid levels.
Patients and Methods: Data of 220 individuals diagnosed with obesity were collected from medical records. Obese individuals without cardiovascular risk factors (fasting serum lipids, blood pressure, and glucose) were classified as MHO (n=124). Individuals meeting one or more criteria of cardiovascular risk factors were classified as MUO (n=96). The control group was composed of 111 healthy individuals.
Results: The mean age of the participants was 12.14±3.28 years, including 44.4% (n=147) were males. While there was statistical significance regarding uric acid between obese and healthy individuals (308.11±71.97 umol/L (5.18±1.21 mg/dl), 251.6±70.78 umol/L (4.23±1.19 mg/dl), Z=6.670, p<0.001, respectively). No statistical significance was found between MHO and MUO groups (302.16±69 umol/L (5.08±1.16 mg/dl), 315.84±74.94 umol/L (5.31±1.26 mg/dl), Z=1.265, p=0.206, respectively). However, uric acid had a significant correlation with many variables, such as weight, height, body mass index, triglyceride, high-density lipoprotein and serum insulin levels, but the strongest being with weight (Spearman r=0.525, p<0.001). Moreover, there was no difference between these 3 groups concerning platelet count, mean platelet volume, and platelet distribution width (H; p, 3.620; 0.164, 1.624; 0.444, and 1.948; 0.378, respectively).
Conclusions: This study showed that uric acid level is higher in obese than healthy controls and the most significant correlation with weight. However, uric acid alone is not a good indicator between MHO and MUO groups.  

Keywords

• Adolescent
• Metabolically Healthy Obesity
• Metabolically Unhealthy Obesity
• Children
• Uric Acid

Ürik Asit Metabolik Sağlıksız Çocuk ve Adolesanlarda Ayırt Edici Bir Marker Olabilir mi?

Abstract

Amaç: Bu çalışmada metabolik olarak sağlıklı ve sağlıksız obez çocuklar arasında laboratuvar değerlerinin, özellikle serum ürik asit düzeyleri açısından bir fark olup olmadığı araştırılmıştır.
Gereç ve Yöntemler: Obezite teşhisi konulan çocuk ve adolesan 220 kişinin verileri tıbbi kayıtlardan toplandı. Kardiyovasküler risk faktörleri (açlık serum lipidleri, kan basıncı ve açlık glukoz yüksekliği) olmayan obez bireyler sağlıklı obez (n = 124) olarak sınıflandırıldı. Bir veya daha fazla kardiyovasküler risk faktörü kriterini karşılayan kişiler sağlıksız obez (n = 96) olarak sınıflandırıldı. Kontrol grubu 111 sağlıklı bireyden oluşturuldu.
Bulgular: Çalışmaya alınan olguların yaş ortalaması 12.14 ± 3.28 yıl, %44.4'ü (n = 147) erkekti. Obez bireyler ile sağlıklı kontroller arasında ürik asit düzeyleri arasında istatistiksel anlamlı olarak fark saptandı (sırasıyla, 308.11±71.97 umol/L (5.18±1.21 mg/dl), 251.6±70.78 umol/L (4.23±1.19 mg/dl); Z=6.670, p<0.001), bu fark metabolik olarak sağlıklı ve sağlıksız obezlerde saptanmadı (sırasıyla, 302.16±69 umol/L (5.08±1.16 mg/dl), 315.84±74.94 umol/L (5.31±1.26 mg/dl); Z=1.265, p=0.206). Ancak kilo, boy, vücut kitle indeksi, trigliserid, yüksek yoğunluklu lipoprotein ve insülin serum seviyeleri gibi ürik asit düzeyi üzerine etkili birçok faktör saptandı, fakat en güçlü oranda korelasyon vücut ağırlığı ile ürik asit düzeyi arasında saptandı (Spearman r=0.525, p <0,001). Ayrıca trombosit sayısı, ortalama trombosit hacmi ve trombosit dağılım genişliği açısından bu 3 grup arasında fark yoktu (sırasıyla H; p, 3.620; 0.164, 1.624; 0.444 ve 1.948; 0.378).
Sonuç: Bu çalışma, obezlerde ürik asit düzeyinin sağlıklı kontrollere göre daha yüksek olduğunu, ürik asit düzeyleri ile en güçlü korelasyon gösteren parametrenin kilo olduğunu göstermektedir. Ancak ürik asit tek başına metabolik olarak sağlıklı ve sağlıksız obezlerde iyi bir gösterge değildir.  

Keywords

• Adolesan
• Adolesan
• Metabolik sağlıklı obezite
• Çocuk
• Ürik asit

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