The Relationship Between Esophageal Corrosion and Dynamic Thiol-Disulfide and Ischemia Modified Albumin Levels in Children

Abstract

Objective: Corrosive burns of esophagus occurring in childhood has life-threatening complications. Its detection via biochemical substrates instead of performing esophagoscopy is crucially important for children. Determination of oxidative stress markers including thiol/disulfide homeostasis and ischemia modified albumin levels may provide valuable information for corrosive esophageal burns. The study aims to investigate the relation between esophageal corrosion and thiol/disulfide homeostasis and ischemia-modified albumin levels in children.

Material and Methods: Eighteen patients who underwent esophagoscopy due to corrosive substances intake (esophagoscopy group) and age and gender-matched 18 volunteers (control group) were included study. Blood levels of native thiol (-SH), total thiol (SH+SS), dynamic disulfide (SS), albumin and ischemia modified albumin (IMA) were measured in both groups. SPSS 17.0 was used for analyses and p <0.05 was considered significant.

Results: Laboratory results of cases with esophageal burn (n = 13) and without burn (n = 5) and control (n = 18) were compared. There was a significant decrease in levels of dynamic disulfide (p=0.03), and dynamic disulfide/total thiol ratio (p=0.01) of children with esophageal burn compared with that of children with no burn or were found to be statistically significant.

Conclusion: Decreased levels of disulphide and dynamic disulfide/total thiol ratio would be used as a laboratory test to show corrosion in the esophagus. However, randomized, multicentric studies with larger samples are needed.

Keywords

• Corrosive esophageal burns;
• oxidative stress
• thiol/disulfide homeostasis
• Ischemia Modified Albumin
• children

Çocuklarda Özefagus Korozyonu ile Dinamik Tiyol-Disülfid ve İskemi Modifiye Albumin Düzeyleri Arasındaki İlişki

Abstract

Amaç: Çocukluk çağında özoagusun korozif yanıkları hayatı tehdit eden ciddi bir durumdur. Çocuklarda korozif tanısı koymada özefagoskopi yapmak yerine biyokimyasal marker ile saptamak çok önemlidir. Oksidatif stres belirteçlerinden tiyol / disülfid homeostazı ve iskemi modifiye albümin seviyelerinin belirlenmesi, korozif özofagus yanıkları için tanısal bilgiler sağlayabilir. Çalışma, çocuklarda özofagus korozyonu ile tiyol / disülfid homeostazı ve iskemi modifiye albümin düzeyleri arasındaki ilişkiyi araştırmayı amaçlamaktır.

Gereç ve Yöntemler: Çalışmaya, korozif madde alımı nedeni ile özofagoskopi yapılan 18 hasta (özofagoskopi grubu) ve yaş ve cinsiyet uyumlu 18 gönüllü (kontrol grubu) dâhil edildi. Her iki grupta nativ tiyol (-SH), toplam tiyol (SH+SS), dinamik disülfid (SS), albümin ve iskemi modifiye albümin (İMA) kan seviyeleri ölçüldü. Analizler için SPSS 17.0 kullanıldı ve p <0.05 anlamlı kabul edildi.

Bulgular: Özofagus yanığı olan (n = 13) ve yanık olmayan (n = 5) olguların ve kontrol grubunun (n = 18) laboratuvar sonuçları karşılaştırıldı. Özofagus yanığı olan çocukların dinamik disülfid düzeylerinde (p=0.03) ve dinamik disülfid / toplam tiyol oranında (p=0.01) yanık olmayan çocuklara göre azalma görüldü veya istatistiksel olarak anlamlı bulundu.

Sonuç: Disülfid seviyesi ve dinamik disülfid / total tiyol oranının azalmasından dolayı özefagus korozyonu göstermek için bir laboratuvar testi olarak kullanılabilir. Ancak, çok merkezli, randomize, daha fazla örneklemli çalışmalara ihtiyaç vardır.

Keywords

• korozif özefagus yanıkları
• çocuk
• oksidatif stres
• tiyol-disülfid dengesi
• iskemi modifiye albumin

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