Comparison Between Cardio-Electrophysiological Balance Index and Corrected Values in Different Age Groups Among School-Age Children

Year 2024, Articles Online First, 1 - 6

Ömer Güneş Ahmet Yasin Güney Halit Halil Aylin Kayalı Akyol Özhan Akyol Fatih Üçkardeş Bahar Öztelcan Gündüz Yüksel Hakan Aydoğmuş Utku Pamuk Ayhan Kılıç Bülent Ünay

https://doi.org/10.12956/tchd.1449621

Abstract

Objective: The index of cardio-electrophysiological balance (iCEB) is a new non-invasive marker that can be used to predict malignant ventricular arrhythmias. Pediatric studies on iCEB are limited in number. Our study aimed to determine the range of its values in different age groups among school-age children.

Material and Methods: The study included patients aged 5-17 admitted to Gülhane Training and Research Hospital Pediatric Cardiology Outpatient Clinic between March 2020 and March 2022 without a history of chronic disease, cardiac disease, arrhythmia, or cardiac surgery. Participants were categorised into ages 5-8, 9-12, and 13-17. The iCEB and iCEBc values were calculated and compared between groups.

Results: The total number of 1303 cases were categorised into the 5-8 (n=270), 9-12 (n=389), and 13-17 (n=644) age groups. The mean iCEB and iCEBc values for all age groups were 4.39±0.53 and 5.16±0.53, respectively. Any difference was not detected among age groups of 5-8, 9-12, and 13-17 years in terms of iCEB and iCEBc values (4.42±0.56, 4.39±0.53 and 4.39±0.52 vs. 5.19±0.56, 5.15±0.55 and 5.16±0.52, respectively). However, a significant difference was found between male (n=699) and female (n=604) patients in terms of mean iCEB (4.23±0.52 vs. 4.59±0.47) and iCEBc (4.98±0.53 vs. 5.38±0.46) values (p <0.001).

Conclusion: iCEB and iCEBc values in school-age children did not differ according to age groups. However, these values differed between boys and girls. This study is the first to reveal normal ranges of iCEB and iCEBc values in school-age children.

Keywords

school age, child, ECG, iCEB, iCEBc

Ethical Statement

-

Supporting Institution

-

Project Number

-

Thanks

-

Okul Çağındaki Çocuklarda Farklı Yaş Gruplarında Kardiyo-Elektrofizyolojik Denge İndeksi ve Düzeltilmiş Değerlerinin Karşılaştırılması

Abstract

Amaç: Kardiyo-elektrofizyolojik denge indeksi (iCEB), malign ventriküler aritmileri tahmin etmede kullanılabilecek yeni, invazif olmayan bir belirteçtir. iCEB ile ilgili pediatrik çalışmalar sayıca sınırlıdır. Çalışmamız okul çağındaki çocuklarda farklı yaş gruplarındaki iCEB değerlerinin aralığını belirlemeyi amaçladı.

Gereç ve Yöntemler: Gülhane Eğitim ve Araştırma Hastanesi Çocuk Kardiyoloji Polikliniğine Mart 2020-Mart 2022 tarihleri arasında başvuran, kronik hastalık, kalp hastalığı, aritmi ve kalp cerrahisi öyküsü olmayan 5-17 yaş arası hastalar çalışmaya dahil edildi. Katılımcılar 5-8, 9-12 ve 13-17 yaş gruplarına ayrıldı. iCEB ve iCEBc değerleri hesaplandı ve gruplar arasında karşılaştırıldı.

Bulgular: Toplam 1303 vaka 5-8 (n=270), 9-12 (n=389) ve 13-17 (n=644) yaş gruplarına ayrıldı. Tüm yaş grupları için ortalama iCEB ve iCEBc değerleri sırasıyla 4.39±0.53 ve 5.16±0.53’di. iCEB ve iCEBc değerleri açısından 5-8, 9-12 ve 13-17 yaş grupları arasında farklılık saptanmadı (4.42±0.56, 4,.39±0.53 ve 4.39±0.52 vs. 5.19±0.56, 5.15±0.55 ve 5.16±0.52). Ancak erkek (n=699) ve kadın (n=604) hastalar arasında ortalama iCEB (4.23±0.52 vs. 4.59±0.47) ve iCEBc (4.98±0.53 vs. 5.38±0.46) değerleri açısından anlamlı fark bulundu (p <0.001).

Sonuç: Okul çağındaki çocuklarda iCEB ve iCEBc değerleri yaş gruplarına göre farklılık göstermedi. Ancak bu değerler kız ve erkek çocuklar arasında farklılık göstermektedir. Bu çalışma, okul çağındaki çocuklarda iCEB ve iCEBc değerlerinin normal aralıklarını ortaya koyan ilk çalışmadır.

Keywords

okul yaşı, çocuk, EKG, iCEB, iCEBc

Project Number

-

References

• Lu HR, Yan GX, Gallacher DJ. A new biomarker--index of cardiac electrophysiological balance (iCEB)-plays an important role in drug-induced cardiac arrhythmias beyond QT-prolongation and Torsades de Pointes (TdPs). J Pharmacol Toxicol Methods 2013;68:250-9.
• Asoglu R, Tibilli H, Asoglu E, Aladag N, Ozdemir M, Suner A. Evaluation of index of cardiac electrophysiological balance in COVID-19 patients. Bratisl Lek Listy 2021;122:598-604.
• Alareedh M, Nafakhi H, Shaghee F, Nafakhi A. Electrocardiographic markers of increased risk of sudden cardiac death in patients with COVID-19 pneumonia. Ann Non-invasive Electrocardiol 2021;26:e12824.
• Sivri S, Çelik M. Evaluation of index of cardiac-electrophysiological balance before and after hemodialysis in patients with end-stage renal disease. J Electrocardiol 2019;54:72-5.
• Alsancak Y, Korkmaz C. Evaluation of Index of Cardiac-Electrophysiological Balance and Electrocardiographic Alternations in Patients with Sarcoidosis. Sakarya Med J 2021;11: 193-200.
• Zorlu Ç, Ömür S. E. Evaluation of Index of Cardiac Electrophysiological Balance in Type 1 Diabetes Mellitus. Journal of Harran University Medical Faculty 2021;18: 441-5.
• Kaya H, Suner A, Koparal M, Yucetas SC, Kafadar S. Evaluation of Tp-e interval, Tp-e/QT ratio and index of cardiac-electrophysiological balance in patients with tinnitus. BMC Cardiovasc Disord 2021;21:415.
• Yücetas SC, Kaya H, Kafadar S, Kafadar H, Tibilli H, Akcay A. Evaluation of index of cardiac-electrophysiological balance in patients with subarachnoid hemorrhage. BMC Cardiovasc Disord 2022;22:477.
• Okşul M, Bilge Ö, Türken A, Işık F, Akyüz A, Çap M, et al. Evaluation of Index of Cardiac Electrophysiological Balance in Patients With Myotonic Dystrophy Type 1. Cureus 2023;15:e34600.
• Neyzi O, Bundak R, Gökçay G, Günöz H, Furman A, Darendeliler F, et al. Reference Values for Weight, Height, Head Circumference, and Body Mass Index in Turkish Children. J Clin Res Pediatr Endocrinol 2015;7:280-93.
• Keskinoglu A, Keskinoglu B, Ozgur S, Kose T. Blood Pressure Percentiles in Turkish Children and Adolescents. J Pediatr Res 2020;7:279-85.
• Rijnbeek PR, Witsenburg M, Schrama E, Hess J, Kors JA. New normal limits for the paediatric electrocardiogram. Eur Heart J 2001;22:702-11.
• Sap F, Guney AY, Oflaz MB, Baysal T. Index of Cardiac Electrophysiological Balance in Electrocardiography of Children with Acute Rheumatic Carditis. Selcuk Med J 2022;38: 64-70.
• Robyns T, Lu HR, Gallacher DJ, Garweg C, Ector J, Willems R, et al. Evaluation of Index of Cardio-Electrophysiological Balance (iCEB) as a New Biomarker for the Identification of Patients at Increased Arrhythmic Risk. Ann Non-invasive Electrocardiol 2016;21:294-304.
• Chen X, Wang Z, Liu L, Zhang W, Tang Z, Liu B, et al. Prognostic value of index of cardiac electrophysiological balance among U.S. middle-aged adults. Front Cardiovasc Med 2023;10:1139967.
• Özdemir L, Sökmen E. Effect of habitual cigarette smoking on the index of cardiac electrophysiological balance in apparently healthy individuals. J Electrocardiol 2020;59:41-4.
• Afsin A, Asoglu R, Kobat MA, Asoglu E, Suner A. Evaluation of Index of Cardio-Electrophysiological Balance in Patients With Atrial Fibrillation on Antiarrhythmic-Drug Therapy. Cardiol Res 2021;12:37-46.