İlaç Alerjisi Ayırıcı Tanısında Mycoplasma Pneumoniae’nin Neden Olduğu Döküntü ve Mukozit (Mırm)

Year 2024, Articles Online First, 1 - 4

Sinem Polat , Hacer İlbilge Ertoy Karagöl , Gizem Koken , A Tapisiz , Arzu Bakırtaş

https://doi.org/10.12956/tchd.1499268

Abstract

Mycoplasma pneumoniae (MP) enfeksiyonu ile ilişkili mukokütanöz döküntüler, MP’nin neden olduğu döküntü ve mukozit olarak tanımlanan yeni bir terimle açıklanmaktadır. Amoksisilin-klavulanik asit’in ilk dozundan sonra, 17 yaşındaki bir erkek çocuğunda döküntü, iki taraflı pürülan konjonktivit, ağız ve genital ülserler gelişmiş ve hastaya ilaç alerjisi ön tanısı konulmuştur. Hasta, Stevens-Johnson sendromu ön tanısıyla hastaneye yatırılıp, sistemik steroid tedavisine başlanmıştır. Takip sürecinde, hastada laboratuvar testleri ile doğrulanan MP nedenli pnömoni gelişmiş ve hastaya MP’nin neden olduğu döküntü ve mukozit tanısı konulmuştur. Hasta, azitromisin ve intravenöz immünoglobulin tedavisi ile iki hafta içinde tamamen iyileşmiştir. Bu olguda, ilaç alerjisi ayırıcı tanısında dikkate alınması gereken MP’nin neden olduğu döküntü ve mukozitli bir olguyu tartışmayı ve bu duruma dair farkındalığı artırmayı amaçladık.

Keywords

Ergen, ilaç alerjisi, Mycoplasma pneumoniae’nin neden olduğu döküntü ve mukozit

Mycoplasma Pneumoniae Induced Rash and Mucositis (Mirm): in the Differential Diagnosis of Drug Allergy

Abstract

Mucocutaneous eruptions associated with Mycoplasma pneumoniae (MP) infection has been newly termed ‘MP-induced rash and mucositis (MIRM)’. A 17-year-old male developed a rash, bilateral purulent conjunctivitis, and oral and genital ulcers after the first dose of amoxicillin-clavulanic acid, initially considered as a drug allergy. Following hospitalization under a preliminary diagnosis of Stevens-Johnson syndrome and initiation of systemic steroids, he developed pneumonia. Laboratory tests confirmed MP infection, leading to a refined diagnosis of MIRM. The patient fully recovered within two weeks following treatment with azithromycin and intravenous immunoglobulin. This case underscores the importance of considering MIRM in the differential diagnosis of drug allergies and aims to enhance awareness of this condition.

Keywords

adolescent, drug allergy, mycoplasma pneumoniae induced rash and mucositis

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