Abstract
Kısa etkili inhale beta 2 mimetik bir ilaç olan salbutamol, bronkospazm ve solunum sıkıntısı durumlarında çok sık kullanılmaktadır ama ülkemizde intihar amaçlı alımı nadir görülen bir durumdur. Salbutamole bağlı komplikasyonlar iyi bilinmektedir ve terapotik dozlarda da ortaya çıkabilir. İlaca bağlı toksikasyon geliştiğinde hiperaktivite, tremor, konvülzyon, hiperglisemi, hipokalemi, hipomagnezemi, laktik asidoz, hipotansiyon, hipertansiyon, konjestif kalp yetmezliği, miyokard iskemisi, atriyal ve ventriküler ektopik atımlar, atriyal aritmiler, QT uzaması ve ventriküler taşikardi gibi aritmiler ile ani kardiyak ölüm ortaya çıkabilir. Bu makalede, intihar amaçlı olarak salbutamolün tablet formundan 200 mgr kullanan 15 yaşındaki bir hasta sunuldu ve literatür bilgileri eşliğinde çocuklarda salbutamol zehirlenmesine yaklaşım tartışıldı.
Keywords
References
- Kayaalp SO. Bronkodilatatör ilaçlar ve diğer antiastmatik ilaçlar. Kayaalp SO (ed). Akılcıl Tedavi Yönünden Tıbbi Farmakoloji. Pelikan Yayıncılık, 2012:619-40.
- Öztürk S, Özkısa T. Beta adrenerjik agonistler. Türkiye Klinikleri J Allergy-Special Topics 2012;5:25-33.
- Lulich KM, Goldie RG, Ryan G, Paterson JW. Adverse reactions to beta 2-agonist bronchodilators. Med Toxicol 1986;1:286-99.
- Danenberg HD. Salbutamol intoxication. Harefuah 1997;132:549- 51.
- Uysal E, Solak S, Carus M,Uzun N, Cevik E. Salbutamol abuse is associated with ventricular fibrillation. Turk J Emerg Med 2015;15:87-9.
- Karadeniz C, Özdemir R, Yozgat Y, Meşe T. Adenosine for Salbutamol induced supraventricular tachycardias: Letter to the editor. Pediatr Heart J 2014;1:323-4.
- Bremner P, Woodman K, Burgess C, Crane J, Purdie G, Pearce N, et al. A comparison of the cardiovascular and metabolic effects of formoterol, salbutamol and fenoterol. Eur Respir J 1993;6:204-10.
- Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: A meta-analysis. Chest 2004;125:2309-21.
- Boucher A, Payen C, Garayt C, Ibanez H, Dieny A, Doche C, et al. Salbutamol misuse or abuse with fatal outcome: A case-report. Hum Exp Toxicol 2011;30:1869-71.
- Glatstein MM, Rimon A, Koren L, Marom R, Danino D, Scolnik D. Unintentional oral beta agonist overdose: Case report and review of the literature. Am J Ther 2013;20:311-4.
- Yilmaz HL, Kucukosmanoglu O, Hennes H, Celik T. Salbutamol intoxication: Is salbutamol a drug-inducing fever? A case report and treatment strategy. Eur J Emerg Med 2002;9:179-82.
Abstract
Salbutamol, a drug with short-acting inhaled beta 2 mimetic effect, is very frequently used in cases of bronchospasm and respiratory distress; however, its intake for suicide purposes is rare in Turkey. Salbutamol-induced complications are well established and may be seen at therapeutic doses. When drug-related intoxication develops, hyperactivity, tremor, convulsion, hyperglycemia, hypokalemia, hypomagnesemia, lactic acidosis, hypotension, hypertension, congestive heart failure, myocardial ischemia, atrial and ventricular ectopic heart beats, atrial arrhythmias, QT prolongation and arrhythmias such as ventricular tachycardia and sudden cardiac death may occur. This paper presents a 15-year-old patient who used 200 mg salbutamol in tablet form for suicide purposes and discusses the approach to salbutamol intoxication with a review of the literature information
Keywords
References
- Kayaalp SO. Bronkodilatatör ilaçlar ve diğer antiastmatik ilaçlar. Kayaalp SO (ed). Akılcıl Tedavi Yönünden Tıbbi Farmakoloji. Pelikan Yayıncılık, 2012:619-40.
- Öztürk S, Özkısa T. Beta adrenerjik agonistler. Türkiye Klinikleri J Allergy-Special Topics 2012;5:25-33.
- Lulich KM, Goldie RG, Ryan G, Paterson JW. Adverse reactions to beta 2-agonist bronchodilators. Med Toxicol 1986;1:286-99.
- Danenberg HD. Salbutamol intoxication. Harefuah 1997;132:549- 51.
- Uysal E, Solak S, Carus M,Uzun N, Cevik E. Salbutamol abuse is associated with ventricular fibrillation. Turk J Emerg Med 2015;15:87-9.
- Karadeniz C, Özdemir R, Yozgat Y, Meşe T. Adenosine for Salbutamol induced supraventricular tachycardias: Letter to the editor. Pediatr Heart J 2014;1:323-4.
- Bremner P, Woodman K, Burgess C, Crane J, Purdie G, Pearce N, et al. A comparison of the cardiovascular and metabolic effects of formoterol, salbutamol and fenoterol. Eur Respir J 1993;6:204-10.
- Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: A meta-analysis. Chest 2004;125:2309-21.
- Boucher A, Payen C, Garayt C, Ibanez H, Dieny A, Doche C, et al. Salbutamol misuse or abuse with fatal outcome: A case-report. Hum Exp Toxicol 2011;30:1869-71.
- Glatstein MM, Rimon A, Koren L, Marom R, Danino D, Scolnik D. Unintentional oral beta agonist overdose: Case report and review of the literature. Am J Ther 2013;20:311-4.
- Yilmaz HL, Kucukosmanoglu O, Hennes H, Celik T. Salbutamol intoxication: Is salbutamol a drug-inducing fever? A case report and treatment strategy. Eur J Emerg Med 2002;9:179-82.
Details
| Other ID | JA64GB79DU |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | June 1, 2017 |
| Submission Date | June 1, 2017 |
| Published in Issue | Year 2017 Volume: 11 Issue: 2 |
The publication language of Turkish Journal of Pediatric Disease is English.
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