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Transient Neurological Complication During Central Venous Catheterization in a Child with Hyperleukocytosis

Year 2017, Volume: 11 Issue: 1, 65 - 68, 01.04.2017

Abstract

Hyperleukocytosis is seen in 5-20% of childhood leukemia cases and it is a poor prognostic factor. Leukapheresis is an effective emergency treatment method by reducing the number of blasts and control of neurological symptoms. Here we report a pediatric patient whose physical status was ASA IVE. He was diagnosed as acute leukemia and had neurologic deterioration together with late recovery from anesthesia after central venous catheterization. Morbidity and mortality of central venous catheterization, which is necessary for leukapheresis treatment, is high. Therefore, all the risks of the disorder and the central catheterization procedure should be described in detail to the family by clinician and the anesthesiologist during preoperative evaluation. We suggest using local anesthesia during this procedure in suitable cases and avoiding sedation or general anesthesia. When there is disorientation, we must remember that this can be a sign of a cerebrovascular event

References

  • İrken G, Ören H, Öniz H, Çetingül N, Vergin C, Atabay B, et al. Hyperleukocytosis in childhood acute lymphoblastic leukemia: Complications and treatment outcome. Turk J Hematol 2006; 23:142-6.
  • Apak H, Karaman S, Celkan T, Özkan A, Canbolat A, Yantri L, ve ark. Akut lösemili hastalarda hiperlökositoz tedavisinde basit ve etkili kan değişimi yöntemi (ön sonuçlar). Türk Ped Arş 2008;43:24- 8.
  • Maurer HS, Steinherz PG, Gaynon PS, Finklestein JZ, Sather HN, Reaman GH, et al. The effect of initial management of hyperleukocytosis on early complications and outcome of children with acute lymphoblastic leukemia. J Clin Oncol 1988;6:1425-32.
  • Doğan M, Sal E, Açıkgöz M, Bora A, Öner AF. Lökostaz sonrası intrakraniyal kanama gelişen akut myeloid lösemi’li (AML) bir olgu sunumu. Van Tıp Dergisi 2008;15:30-3.
  • Porcu P, Farag S, Marcucci G, Cataland SR, Kennedy MS, Bissell M. Leukocytoreduction for acute leukemia. Ther Apher 2002;6:399- 400.
  • Strauss RA, Gloster ES, McCallister JA, Jimenez JF, Neuberg RW, Berry DH. Acute cytoreduction techniques in the early treatment of hyperleukocytosis associated with childhood hematologic malignancies. Med Pediatr Oncol 1985;13:346-51.
  • Porcu P, Danielson CFM, Orazi A, Buckwalter K, Lurito J, Skipworth E, et al. Acute lymphoblastic leukemia with hyperleukocytosis (HL) and supratentorial hemorrhage treated with leukapheresis. J Clin Apheresis 1998;13:82.
  • Eisen LA, Narasimhan M, Berger JS, Mayo PH, Rosen MJ, Schneider RF. Mechanical complications of central venous catheters. J Intensive Care Med 2006;21:40-6.
  • Koroglu M, Demir M, Koroglu BK, Sezer MT, Akhan O, Yildiz H, et al. Percutaneous placement of central venous catheters: comparing the anatomical landmark method with the radiologically guided technique for central venous catheterization through the internal jugular vein in emergent hemodialysis patients. Acta Radiol 2006;47:43-7.
  • Bo-Linn GW, Anderson DJ, Anderson KC, McGoon MD. Percutaneous central venous catheterization performed by medical house officers: A prospective study. Cath Cardiovasc Diagn 1982;8:23-29.

Hiperlökositozu Olan Çocuk Hastada Santral Venöz Kateterizasyon Sırasında Gelişen Geçici Nörolojik Komplikasyon

Year 2017, Volume: 11 Issue: 1, 65 - 68, 01.04.2017

Abstract

Hiperlölositoz, çocukluk çağı lösemilerinin %5-20’sinde görülen, prognozu kötü etkileyen bir risk faktörüdür. Lökoferez bu hasta grubunda, blast sayısını etkin bir şekilde azaltarak nörolojik semptomların kontrolünü sağlayan, etkili, acil bir tedavi yöntemidir. Biz bu olgu sunumunda, hiperlökositoz nedeniyle lökoferez planlanan, ASA IVE, çocuk hastada santral venöz kateterizasyon sırasında gelişen nörolojik dezoryantasyon ve geç derlenmeyi tartışmayı planladık. Lökoferez için uygulanacak santral venöz kateterizasyon morbidite ve mortalitesi yüksek bir girişimdir. İşlemden önce, hastayı takip eden klinisyen ve anestezistin, hastalığın ve santral girişimin tüm risklerini aileye ayrıntılı anlatması gerektiği, işlem sırasında mümkün olan olgularda sadece lokal anestezi uygulanması, sedasyon ve genel anesteziden kaçınılması, hastanın bilinç durumunda bozulma olduğunda serebrovasküler olayların akla getirilerek hızla tanı ve tedavi için değerlendirilmesi gerektiği kanaatindeyiz.

References

  • İrken G, Ören H, Öniz H, Çetingül N, Vergin C, Atabay B, et al. Hyperleukocytosis in childhood acute lymphoblastic leukemia: Complications and treatment outcome. Turk J Hematol 2006; 23:142-6.
  • Apak H, Karaman S, Celkan T, Özkan A, Canbolat A, Yantri L, ve ark. Akut lösemili hastalarda hiperlökositoz tedavisinde basit ve etkili kan değişimi yöntemi (ön sonuçlar). Türk Ped Arş 2008;43:24- 8.
  • Maurer HS, Steinherz PG, Gaynon PS, Finklestein JZ, Sather HN, Reaman GH, et al. The effect of initial management of hyperleukocytosis on early complications and outcome of children with acute lymphoblastic leukemia. J Clin Oncol 1988;6:1425-32.
  • Doğan M, Sal E, Açıkgöz M, Bora A, Öner AF. Lökostaz sonrası intrakraniyal kanama gelişen akut myeloid lösemi’li (AML) bir olgu sunumu. Van Tıp Dergisi 2008;15:30-3.
  • Porcu P, Farag S, Marcucci G, Cataland SR, Kennedy MS, Bissell M. Leukocytoreduction for acute leukemia. Ther Apher 2002;6:399- 400.
  • Strauss RA, Gloster ES, McCallister JA, Jimenez JF, Neuberg RW, Berry DH. Acute cytoreduction techniques in the early treatment of hyperleukocytosis associated with childhood hematologic malignancies. Med Pediatr Oncol 1985;13:346-51.
  • Porcu P, Danielson CFM, Orazi A, Buckwalter K, Lurito J, Skipworth E, et al. Acute lymphoblastic leukemia with hyperleukocytosis (HL) and supratentorial hemorrhage treated with leukapheresis. J Clin Apheresis 1998;13:82.
  • Eisen LA, Narasimhan M, Berger JS, Mayo PH, Rosen MJ, Schneider RF. Mechanical complications of central venous catheters. J Intensive Care Med 2006;21:40-6.
  • Koroglu M, Demir M, Koroglu BK, Sezer MT, Akhan O, Yildiz H, et al. Percutaneous placement of central venous catheters: comparing the anatomical landmark method with the radiologically guided technique for central venous catheterization through the internal jugular vein in emergent hemodialysis patients. Acta Radiol 2006;47:43-7.
  • Bo-Linn GW, Anderson DJ, Anderson KC, McGoon MD. Percutaneous central venous catheterization performed by medical house officers: A prospective study. Cath Cardiovasc Diagn 1982;8:23-29.
There are 10 citations in total.

Details

Other ID JA69AM42RS
Journal Section Case Report
Authors

Gülsen Keskin This is me

Mine Akın This is me

Sengül Özmert This is me

Devrim Tanıl Kurt This is me

Sibel Saydam This is me

Yeşim Andıran Şenaylı This is me

Pınar Özışık This is me

Gülşah Bayram This is me

Emine Betül Tavil This is me

Publication Date April 1, 2017
Submission Date April 1, 2017
Published in Issue Year 2017 Volume: 11 Issue: 1

Cite

Vancouver Keskin G, Akın M, Özmert S, Kurt DT, Saydam S, Şenaylı YA, Özışık P, Bayram G, Tavil EB. Transient Neurological Complication During Central Venous Catheterization in a Child with Hyperleukocytosis. Türkiye Çocuk Hast Derg. 2017;11(1):65-8.


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