Abstract
İnme, orak hücreli anemili hastalarda ciddi morbiditeye neden olan ve tekrarlayabilen önemli bir komplikasyondur. Riskli hastalar, aylık kan değişimi transfüzyon programına alınırsa inme görülme ihtimali %90 azalmaktadır.Makalede dokuz yaşında hemipleji etiyolojisi araştırılırken orak hücre anemisi tanısı alan bir olgu sunulmuştur. Tanı ve tedavi geciktiği için çok sayıda serebral damarda tıkanıklık ve tekrarlayan enfarktlara bağlı hemipleji gelişmiştir.Orak hücre anemisinin erken tanısı için, tüm yenidoğanlara hemoglobinopati taraması yapılmasını gerekli görüyoruz. Tanı alan hastalara ise iki yaştan sonra uygulanan transkraniyal Doppler ile yüksek riskli olanlar aylık kan değişimi transfüzyon programına alınmalıdır.
Keywords
References
- Lanzkowsky P. Manual of pediatric hematology and oncology (5th ed). San Diego: Academic Press 2011:200-29.
- Wang WC. The pathophysiology, prevention, and treatment of stroke in sickle cell disease. Curr Opin Hematol 2007;14:191-7.
- Kossorotoff M, Grevent D, de Montalembert M. Cerebral vasculo- pathy in pediatric sickle-cell anemia. Arch Pediatr 2014;21:404-14.
- Brousse V, Gandhi S, de Montalembert M, Height S, Dick MC, O’Driscoll S, et al. Combined blood transfusion and hydroxy- carbamide in with sickle cell anaemia. Br J Haematol 2013;160: 255-72.
Abstract
Stroke is a significant cause of morbidity in children with sickle cell disease and may recur. The risk of a first stroke is reduced by 90% in patients enrolled in a monthly transfusion exchange program. We report a case of a 9-year-old child who was diagnosed with sickle cell anemia at this delayed age when referred for investigation of the etiology of hemiplegia. The lack of diagnosis and treatment had caused recurrent cerebral infarcts leading to hemiplegia due to multiple vessel occlusions.It is crucial to implement a neonatal screening program for hemoglobinopathies for the early diagnosis of sickle cell anemia. Transcranial Doppler screening should be considered after two years age for patients diagnosed with sickle cell anemia and those with high risk should be enrolled in a monthly transfusion exchange program
Keywords
References
- Lanzkowsky P. Manual of pediatric hematology and oncology (5th ed). San Diego: Academic Press 2011:200-29.
- Wang WC. The pathophysiology, prevention, and treatment of stroke in sickle cell disease. Curr Opin Hematol 2007;14:191-7.
- Kossorotoff M, Grevent D, de Montalembert M. Cerebral vasculo- pathy in pediatric sickle-cell anemia. Arch Pediatr 2014;21:404-14.
- Brousse V, Gandhi S, de Montalembert M, Height S, Dick MC, O’Driscoll S, et al. Combined blood transfusion and hydroxy- carbamide in with sickle cell anaemia. Br J Haematol 2013;160: 255-72.
Details
| Other ID | JA62AE69TK |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | August 1, 2016 |
| Submission Date | August 1, 2016 |
| Published in Issue | Year 2016 Volume: 10 Issue: 3 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
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