Alerjik İnflamasyonda Yeni Aktör Trombositler Hemostaz sürecinin en önemli elemanlarından olan trombositlerin son yıllarda yapılan çalışmalar ile immün yanıtın oluşmasında
Abstract
Trombosit aktivasyonun belirlenmesi oldukça zor süreçler gerektirmektedir. Ancak ortalama trombosit volümü basit bir metodoloji olarak trombosit aktivasyonun göstergesi olarak kabul edilmektedir. Bu yöntem ile bir çok hastalıkta trombosit aktivasyonu değerlendirilmiştir. Alerjik hastalıklarda da (kronik ürtiker, astım, alerjik rinit vb) ortalama trombosit volüm değişiklikleri ile aktivasyon göstergesi olarak değerlendirilmiştir (8,9). Ancak bu çalışmalarda volüm değişiklikleri gösterilmiş olmakla beraber halen tartışmalı olma özelliğini korumaktadır. Dergimizin bu sayısında Kara ve Ark (10). Tarafından yapılan çalışmada da astımlı hastalarda atak sırasında trombositlerin aktivasyonu değerlendirilmiştir. Trombostilerin atak sırasında aktive olduğu ve tanıya da katkısı olabileceği gösterilmiştir. Astım atağı sırasında trombosit volüm değişikliklerini inceleyen çalışmalar oldukça sınırlı sayıdadır. Çalışma planı ve aktivasyonu gösteren bir çok parametrenin çalışılması ile de bilime önemli katkıları olacaktır. Sonuç olarak yeni araştırmalar ile trombositlerin alerjik hastalıkların patogenezinde ki yeri daha iyi aydınlatılacak ve buna paralel olarak tedavi seçenekleri geliştirilecektir
Keywords
References
- Idzko M, Pitchford S, Page C. Role of platelets in allergic airway inflammation. J Allergy Clin Immunol 2015;135:1416-23.
- M. Capron, M. Joseph. The low affinity receptor for IgE on eosinophils and platelets. Monogr Allergy 1991;29:63-7.
- Page C, Pitchford S. Platelets and allergic inflammation. Clin Exp Allergy 2014;44:901-13.
- Dürk T, Duerschmied D, Müller T, Grimm M, Reuter S, Vieira RP, et al. Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation. Am J Respir Crit Care Med 2013;187:476-85.
- Yeaman MR. Platelets: at the nexus of antimicrobial defence. Nat Rev Microbiol 2014;12:426–437
- de Stoppelaar SF, van ‘t Veer C, Claushuis TA, Albersen BJ, Roelofs JJ, van der Poll T. Thrombocytopenia impairs host defense in gram- negative pneumonia-derived sepsis in mice. Blood 2014;124:3781-90.
- Page CP. The involvement of platelets in non-thrombotic processes. Trends Pharmacol Sci,1988;9:66-71.
- Vena GA, Cassano N, Marzano AV, Asero R. The Role of Platelets in Chronic Urticaria. Int Arch Allergy Immunol 2016;169:71-9.
- Doğru M, Aktas A, Ozturkmen S. Mean platelet volume increased in children with asthma.Pediatr Allergy Immunol 2015;26:823-6.
- Tural Kara T, Yılmaz Özbek Ö, Tahire Köksal B. Evaluation of Platelet Activation During an Asthmatic Attack in Children.Türkiye Çocuk Hast Derg 2016;10:84-9.
Abstract
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Keywords
References
- Idzko M, Pitchford S, Page C. Role of platelets in allergic airway inflammation. J Allergy Clin Immunol 2015;135:1416-23.
- M. Capron, M. Joseph. The low affinity receptor for IgE on eosinophils and platelets. Monogr Allergy 1991;29:63-7.
- Page C, Pitchford S. Platelets and allergic inflammation. Clin Exp Allergy 2014;44:901-13.
- Dürk T, Duerschmied D, Müller T, Grimm M, Reuter S, Vieira RP, et al. Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation. Am J Respir Crit Care Med 2013;187:476-85.
- Yeaman MR. Platelets: at the nexus of antimicrobial defence. Nat Rev Microbiol 2014;12:426–437
- de Stoppelaar SF, van ‘t Veer C, Claushuis TA, Albersen BJ, Roelofs JJ, van der Poll T. Thrombocytopenia impairs host defense in gram- negative pneumonia-derived sepsis in mice. Blood 2014;124:3781-90.
- Page CP. The involvement of platelets in non-thrombotic processes. Trends Pharmacol Sci,1988;9:66-71.
- Vena GA, Cassano N, Marzano AV, Asero R. The Role of Platelets in Chronic Urticaria. Int Arch Allergy Immunol 2016;169:71-9.
- Doğru M, Aktas A, Ozturkmen S. Mean platelet volume increased in children with asthma.Pediatr Allergy Immunol 2015;26:823-6.
- Tural Kara T, Yılmaz Özbek Ö, Tahire Köksal B. Evaluation of Platelet Activation During an Asthmatic Attack in Children.Türkiye Çocuk Hast Derg 2016;10:84-9.
Details
| Other ID | JA66JF43ZZ |
|---|---|
| Journal Section | Editorial |
| Authors | |
| Publication Date | June 1, 2016 |
| Submission Date | June 1, 2016 |
| Published in Issue | Year 2016 Volume: 10 Issue: 2 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
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