Çocuklarda Astım Atağında Trombosit Aktivasyonun Değerlendirilmesi

Year 2016, Volume: 10 Issue: 2, 84 - 89, 01.06.2016

Tugce Tural Kara Ozlem Yılmaz Özbek Burcu Tahire Koksal

Abstract

Amaç: Astım havayollarının kronik inflamatuvar bir hastalığıdır. Allerjik inflamasyon özellikle mast hücreler, eozinofiller, T lenfositler ve trombositlerin toplanmasıyla karakterizedir. Astımlı çocuklarda atak anında ve ataktan en az 1 ay sonraki dönemde ortalama trombosit hacmi (MPV), trombosit dağılım aralığı (PDW), plateletcrit ve p-selektin düzeylerindeki değişimlerin belirlenerek atak sırasında bir belirteç olarak kullanılabilirliğinin olup olmadığını araştırdık.Gereç ve Yöntemler: Çalışmaya astım atağındaki 40 çocuk alındı. Hastalardan atak anında ve ataktan en az 1 ay sonra MPV, PDW, PCT, p-selektin, eozinofil ve trombosit sayılarını değerlendirmek için kan örnekleri alındı.Bulgular: Atak anındaki MPV, PCT ve p-selektin düzeyleri ataktan bir ay sonrası ile karşılaştırıldığında daha düşük bulundu.Sonuç: Bulgularımız rutin pratikte sık kullanılan parametreler olan MPV ve PCT değerlerinin astım atağını belirlemede kullanılabileceğini göstermiştir.

Keywords

Astım, Ortalama trombosit hacmi (MPV), Trombosit dağılım aralığı (PDW), Plateletcrit, P-selektin

Evaluation of Platelet Activation During an Asthmatic Attack in Children

Abstract

Objective: Asthma is a chronic inflammatory disease of the airways. Allergic inflammation is characterized by accumulation of various cells, particularly mast cells, eosinophils, T lymphocytes and platelets. We investigated whether changes in mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) and p-selectin levels of children with asthma during and at least 1 month after the attack can be used as a marker.Material and Methods: The study was performed in 40 children who suffered asthma attacks. Blood samples were taken for MPV, PDW, PCT, p-selectin, eosinophil and platelet values during and at least 1 month after the attack. Results: Mean platelet volume, PCT, and p-selectin levels were significantly lower at the time of the attack when compared to those at least 1 month after the attack. Conclusion: Our findings suggest that MPV and PCT, common parameters in routine practice, can be used to determine an asthma attack

Keywords

Asthma, Mean platelet volume (MPV), Platelet distribution width (PDW), Plateletcrit (PCT), P-selectin

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