Abstract
Amaç: Obez adölesanlarda total vücut yağ oranı ve serum ürik asit düzeyinin metabolik parametreler ile olan ilişkisini araştırmak.Gereç ve Yöntemler: Çalışmaya yaşları 10-16 yıl olan 124 adölesan alındı. Normal tartılılar (Kontrol grubu, n=40) ve obezler (Çalışma grubu, n=84) olmak üzere iki grup oluşturuldu. Obez çocuklarda Metabolik Sendrom (MS) olup olmamasına göre, Obez MS (-) (n=45) ve Obez MS (+) (n=39) olmak üzere 2 gruba ayrıldı. Vücut yağ oranı (VYO) biyoelektrik impedans analizi ile ölçüldü.Bulgular: Obez grupla kontrol grubu karşılaştırıldığında Vücut Kitle İndeksi-Standart Deviasyon Skoru (VKI-SDS), bel çevresi (BÇ), vücut yağ oranı-SDS, sistolik ve diyastolik kan basıncı, açlık insülin, HOMA-IR değeri, ürik asit düzeyi, trigliserid ve HDL düzeyleri farklı iken (p<0.001), açlık kan şekeri total kolesterol ve LDL düzeyleri benzerdi (p=0.41; p=0.70 and p=0.28 sırası ile). VYO-SDS ve serum ürik asit düzeyi ile VKI, bel çevresi, kan basıncı, kan şekeri, insülin, HOMA-IR değeri, trigliserid arasında pozitif, HDL arasında negatif korelasyon vardı (p<0.001). Çoklu lineer regresyon analizinde VYO-SDS düzeyleri sistolik kan basıncı (p<0.005), BÇ (p<0.001) ve ürik asit (p<0.005) düzeyi ile ilişkili bulundu.Sonuç: Biyoelektrik impedans analizi ile ölçülen vücut yağ oranı ölçümü ve serum ürik asit düzeyi MS kompenentleri ile yakın ilişkili olup MS tanısında öngördürücü belirteç olarak kullanılabilirler.
References
- Zimmet P, Alberti KG, Kaufman F, Tajima N, Silink M, Arslanian S, et al. The metabolic syndrome in children and adolescents - an IDF consensus report. Pediatr Diabetes 2007;8:299-306.
- Rodriguez G, Moreno LA, Blay MG, Blay VA, Fleta J, Sarria A, et al. Body fat measurement in adolescents: Comparison of skinfold thickness equations with dual-energy X-ray absorptiometry. Eur J Clin Nutr 2005;59:1158-66.
- Rodriguez G, Moreno LA, Blay MG, Blay VA, Garagorri JM, Sarria A, et al. Body composition in adolescents: measurements and metabolic aspects. Int J Obes Relat Metab Disord 2004;(28 Suppl 3):54-58.
- Lindsay RS, Hanson RL, Roumain J, Ravussin E, Knowler WC, Tataranni PA. Body mass index as a measure of adiposity in children and adolescents: Relationship to adiposity by dual energy x-ray absorptiometry and to cardiovascular risk factors. J Clin Endocrinol Metab 2001;86:4061-7.
- Daniels SR, Khoury PR, Morrison JA. The utility of body mass index as a measure of body fatness in children and adolescents: Differences by race and gender. Pediatrics 1997;99:804-7. 3.44 (2.43-4.46) 0.24 (0.004-0.48) p
The Relationship of Metabolic Parameters with Serum Uric Acid and Percentage of Body Fat in Obese Adolescents
Abstract
Objective: To evaluate the relationship of metabolic parameters with serum uric acid and percentage of body fat in obese adolescents.Material and Methods: A total 124 adolescents between 10-16 years of age were included in the study. Two groups were created as normal weight (Control, n=40) and obese (n=84). The obese children were also divided into 2 groups according to the presence or absence of Metabolic Syndrome (MS); Obese MS (-) (n=45) and Obese MS (+) (n=39). Bioelectrical impedance analysis was used to measure the percentage of body fat (BF %).Results: The values of body mass index- standard deviation score (BMI-SDS), waist circumference (WC), total body fat-standard deviation score (BF% -SDS), systolic and diastolic blood pressure (BP), fasting insulin, HOMA-IR, triglyceride, HDL and uric acid were significantly different as expected (p<0.001), whereas the fasting blood glucose, total cholesterol and LDL values were similar (p=0.41, p=0.70 and p=0.28, respectively). Percentage of total body fat - standard deviation score and uric acid was significantly correlated with body BMI-SDS, waist circumference (WC), systolic and diastolic BP, fasting insulin, HOMA-IR, triglyceride and HDL (p<0.001). In the multiple linear regressions, it was demonstrated that BF%-SDS was significantly related to the systolic BP (p<0.005), WC (p<0.001) and uric acid (p<0.005).Conclusion: Total body fat measured via bioelectrical impedance analysis and uric acid had a close relationship with MS components and may be a useful predictive marker for MS diagnosis
References
- Zimmet P, Alberti KG, Kaufman F, Tajima N, Silink M, Arslanian S, et al. The metabolic syndrome in children and adolescents - an IDF consensus report. Pediatr Diabetes 2007;8:299-306.
- Rodriguez G, Moreno LA, Blay MG, Blay VA, Fleta J, Sarria A, et al. Body fat measurement in adolescents: Comparison of skinfold thickness equations with dual-energy X-ray absorptiometry. Eur J Clin Nutr 2005;59:1158-66.
- Rodriguez G, Moreno LA, Blay MG, Blay VA, Garagorri JM, Sarria A, et al. Body composition in adolescents: measurements and metabolic aspects. Int J Obes Relat Metab Disord 2004;(28 Suppl 3):54-58.
- Lindsay RS, Hanson RL, Roumain J, Ravussin E, Knowler WC, Tataranni PA. Body mass index as a measure of adiposity in children and adolescents: Relationship to adiposity by dual energy x-ray absorptiometry and to cardiovascular risk factors. J Clin Endocrinol Metab 2001;86:4061-7.
- Daniels SR, Khoury PR, Morrison JA. The utility of body mass index as a measure of body fatness in children and adolescents: Differences by race and gender. Pediatrics 1997;99:804-7. 3.44 (2.43-4.46) 0.24 (0.004-0.48) p
Details
| Other ID | JA49CZ44EV |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 1, 2016 |
| Submission Date | June 1, 2016 |
| Published in Issue | Year 2016 Volume: 10 Issue: 2 |
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