Abstract
Amaç: Atopik dermatit (AD) çocukluk çağında en sık görülen inflamatuvar deri hastalığıdır. AD, atopik yürüyüşün ilk bulgusu olarak astım ve alerjik rinit olarak devam edebilir. Çalışmada polikliniğimizde AD tanısı almış olan hastalarımızın erken dönem prognozunun belirlenmesi ve gelişen alerjik hastalıklar açısından değerlendirilmesi amaçlandı.Gereç ve Yöntemler: Ankara Çocuk Sağlığı ve Hastalıkları Hematoloji Onkoloji Eğitim Araştırma Hastanesi Çocuk İmmünolojisi ve Alerji Hastalıkları Bölümünde Mart 2009-Ocak 2012 tarihleri arasında AD tanısı almış ve en az 2 yıl süre ile takip edilen hastalar AD bulgularının devamlılığı ve gelişen diğer alerjik hastalıklar açısından değerlendirildi.Bulgular: Çalışmaya, 104 hasta (59 erkek, 45 kız) dahil edildi. İki yıllık izlem sonunda 14 (%13.5) hastanın AD lezyonları devam ediyordu. Hastaların 14 (%13.5)’ünde alerjik rinit gelişmişti ve 16 (%15.4) hastaya astım tedavisi başlanmıştı. Atopik dermatit lezyonlarının devamlılığında besin alerjisi olması risk faktörü olarak bulundu OR (5.1) GA (1.4-18.3) (p=0,011). Astım ve/veya alerjik rinit gelişiminde parental astım varlığı (OR (6.2) (1.4-27.6) p=0,015) ve AD lezyonlarının devam ediyor olması (OR (7.2) (1.7-34.9) p=0,007) risk faktörü olarak bulundu.Sonuç: Çalışmamızda AD lezyonlarının devamlılığı ve astım/alerjik rinit gelişim sıklığı literatüre göre daha düşük bulundu. Hastaların, lezyonların devamlılığı ve gelişebilecek diğer alerjik hastalıklar açısından uzun dönem izlemi gereklidir.
References
- Bogunıewicz M, Leung DYM. Atopic Dermatitis. In: Adkinson NF, Bochner BS, Burks AW, Busse WW, Holgate ST, Lemanske RF, O’Hehir RE (eds). Middleton’s Allergy Principles and Practice. 8th ed. USA: Elsevier Saunders, 2014: 540-64.
- Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol 1980;92:44-7.
- Oranjie AP. Practical issues on interpretation of scoring of atopic dermatitis: SCORAD index, objective SCORAD, patient-oriented SCORAD and three item severity score. Curr Probl Dermatol 2011;41:149-55.
- GINA. http://www.ginasthma.com. 2014. Son ulaşılma tarihi: 4 Haziran 2014.
- Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2) LEN and Aller Gen. Allergy 2008;86:8-160.
- nın devam etme ihtimalini 5 kat arttırıyordu.
- Linna O, Kokkonen J, Lahtela P, Tammela O. Ten- year prognosis for generalized infantile eczema. Acta Paediatr 1992;81:1013-6.
- Kissling S, Wüthrich B. Follow-up of atopic dermatitis after early childhood. Hautarzt 1993;44:569-73.
- Gustafsson D, Sjöberg O, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis- a prospective follow-up to 7 years of age. Allergy 2000;55:240-5.
- Illi S, von Mutius E, Lau S, Nickel R, Grüber C, Niggeman B, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 2004;113:925-31.
- Ballardini N, Kull I, Lind T, Hallner E, Almqvist C, Östblom E, et al. Development and comorbidity of eczema, asthma and rhinitis to age 12-data from the BAMSE birth cohort. Allergy 2012;67: 537-44.
- von Kobyletzky L, Svensson A, Apfelbacher C, Schmitt J. Factors that predict remission of ınfant atopic dermatitis: A systematic review. Acta Derm Venereol 2015;95:389-94.
- Ohshima Y, Yamada A, Hiraoka M, Katamura K, Ito S, Hirao T et al. Early sensitization to house dust mite is a major risk factor for subsequent development of bronchial asthma in Japanese infants with atopic dermatitis: Results of a 4-year followup study. Ann Allergy Asthma Immunol 2002;89:265-70.
- Burrows D, Penman RWB. Prognosis of the eczema-asthma syndrome. Brit Med J 1960;2:825-8.
Abstract
Objective: Atopic dermatitis (AD) is the most frequent inflammatory skin disease in childhood. Atopic dermatitis, as the first manifestation of atopic march may continue as asthma and allergic rhinitis. The aim of this study was to evaluate the early prognosis of AD in children.Material and Methods: Children who were diagnosed with AD before three years old between March 2009 and January 2012, and were followed for at least 2 years in the Pediatric Allergy Department of our tertiary hospital were enrolled in this study. Persistence of AD symptoms and development of asthma and/or allergic rhinitis were explored. Results: One hundred and four patients (59 male, 45 female) were included in the study. Atopic dermatitis persisted in 14 (13.5%) patients. Fourteen patients (13.5%) developed allergic rhinitis and 16 (15.4%) patients developed asthma. Food allergy was found to be a risk factor for persistence of AD lesions (OR (5.1) CI (1.4-18.3) (p=0.011).The presence of parental asthma (OR (6.2) (1.4-27.6) p=0,015) and persistence of AD lesions (OR (7.2) (1.7-34.9) p=0.007) were found to be risk factors for the development of asthma and/or allergic rhinitis.Conclusion: Persistence of atopic dermatitis and development of asthma and/or allergic rhinitis were significantly lower in our study group than in the literature. Long-term follow-up of patients with AD is required
References
- Bogunıewicz M, Leung DYM. Atopic Dermatitis. In: Adkinson NF, Bochner BS, Burks AW, Busse WW, Holgate ST, Lemanske RF, O’Hehir RE (eds). Middleton’s Allergy Principles and Practice. 8th ed. USA: Elsevier Saunders, 2014: 540-64.
- Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol 1980;92:44-7.
- Oranjie AP. Practical issues on interpretation of scoring of atopic dermatitis: SCORAD index, objective SCORAD, patient-oriented SCORAD and three item severity score. Curr Probl Dermatol 2011;41:149-55.
- GINA. http://www.ginasthma.com. 2014. Son ulaşılma tarihi: 4 Haziran 2014.
- Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2) LEN and Aller Gen. Allergy 2008;86:8-160.
- nın devam etme ihtimalini 5 kat arttırıyordu.
- Linna O, Kokkonen J, Lahtela P, Tammela O. Ten- year prognosis for generalized infantile eczema. Acta Paediatr 1992;81:1013-6.
- Kissling S, Wüthrich B. Follow-up of atopic dermatitis after early childhood. Hautarzt 1993;44:569-73.
- Gustafsson D, Sjöberg O, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis- a prospective follow-up to 7 years of age. Allergy 2000;55:240-5.
- Illi S, von Mutius E, Lau S, Nickel R, Grüber C, Niggeman B, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 2004;113:925-31.
- Ballardini N, Kull I, Lind T, Hallner E, Almqvist C, Östblom E, et al. Development and comorbidity of eczema, asthma and rhinitis to age 12-data from the BAMSE birth cohort. Allergy 2012;67: 537-44.
- von Kobyletzky L, Svensson A, Apfelbacher C, Schmitt J. Factors that predict remission of ınfant atopic dermatitis: A systematic review. Acta Derm Venereol 2015;95:389-94.
- Ohshima Y, Yamada A, Hiraoka M, Katamura K, Ito S, Hirao T et al. Early sensitization to house dust mite is a major risk factor for subsequent development of bronchial asthma in Japanese infants with atopic dermatitis: Results of a 4-year followup study. Ann Allergy Asthma Immunol 2002;89:265-70.
- Burrows D, Penman RWB. Prognosis of the eczema-asthma syndrome. Brit Med J 1960;2:825-8.
Details
| Other ID | JA75PJ68DR |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 1, 2016 |
| Submission Date | June 1, 2016 |
| Published in Issue | Year 2016 Volume: 10 Issue: 2 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
The aim of the Turkish Journal of Pediatrics is to publish high-quality original research articles that will contribute to the international literature in the field of general pediatric health and diseases and its sub-branches. It also publishes editorial opinions, letters to the editor, reviews, case reports, book reviews, comments on previously published articles, meeting and conference proceedings, announcements, and biography. In addition to the field of child health and diseases, the journal also includes articles prepared in fields such as surgery, dentistry, public health, nutrition and dietetics, social services, human genetics, basic sciences, psychology, psychiatry, educational sciences, sociology and nursing, provided that they are related to this field. can be published.