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Atopik Dermatitli Hastaların İki Yıllık İzlem Sonuçları

Year 2016, Volume: 10 Issue: 2, 120 - 125, 01.06.2016

Abstract

Amaç: Atopik dermatit (AD) çocukluk çağında en sık görülen inflamatuvar deri hastalığıdır. AD, atopik yürüyüşün ilk bulgusu olarak astım ve alerjik rinit olarak devam edebilir. Çalışmada polikliniğimizde AD tanısı almış olan hastalarımızın erken dönem prognozunun belirlenmesi ve gelişen alerjik hastalıklar açısından değerlendirilmesi amaçlandı.Gereç ve Yöntemler: Ankara Çocuk Sağlığı ve Hastalıkları Hematoloji Onkoloji Eğitim Araştırma Hastanesi Çocuk İmmünolojisi ve Alerji Hastalıkları Bölümünde Mart 2009-Ocak 2012 tarihleri arasında AD tanısı almış ve en az 2 yıl süre ile takip edilen hastalar AD bulgularının devamlılığı ve gelişen diğer alerjik hastalıklar açısından değerlendirildi.Bulgular: Çalışmaya, 104 hasta (59 erkek, 45 kız) dahil edildi. İki yıllık izlem sonunda 14 (%13.5) hastanın AD lezyonları devam ediyordu. Hastaların 14 (%13.5)’ünde alerjik rinit gelişmişti ve 16 (%15.4) hastaya astım tedavisi başlanmıştı. Atopik dermatit lezyonlarının devamlılığında besin alerjisi olması risk faktörü olarak bulundu OR (5.1) GA (1.4-18.3) (p=0,011). Astım ve/veya alerjik rinit gelişiminde parental astım varlığı (OR (6.2) (1.4-27.6) p=0,015) ve AD lezyonlarının devam ediyor olması (OR (7.2) (1.7-34.9) p=0,007) risk faktörü olarak bulundu.Sonuç: Çalışmamızda AD lezyonlarının devamlılığı ve astım/alerjik rinit gelişim sıklığı literatüre göre daha düşük bulundu. Hastaların, lezyonların devamlılığı ve gelişebilecek diğer alerjik hastalıklar açısından uzun dönem izlemi gereklidir.

References

  • Bogunıewicz M, Leung DYM. Atopic Dermatitis. In: Adkinson NF, Bochner BS, Burks AW, Busse WW, Holgate ST, Lemanske RF, O’Hehir RE (eds). Middleton’s Allergy Principles and Practice. 8th ed. USA: Elsevier Saunders, 2014: 540-64.
  • Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol 1980;92:44-7.
  • Oranjie AP. Practical issues on interpretation of scoring of atopic dermatitis: SCORAD index, objective SCORAD, patient-oriented SCORAD and three item severity score. Curr Probl Dermatol 2011;41:149-55.
  • GINA. http://www.ginasthma.com. 2014. Son ulaşılma tarihi: 4 Haziran 2014.
  • Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2) LEN and Aller Gen. Allergy 2008;86:8-160.
  • nın devam etme ihtimalini 5 kat arttırıyordu.
  • Linna O, Kokkonen J, Lahtela P, Tammela O. Ten- year prognosis for generalized infantile eczema. Acta Paediatr 1992;81:1013-6.
  • Kissling S, Wüthrich B. Follow-up of atopic dermatitis after early childhood. Hautarzt 1993;44:569-73.
  • Gustafsson D, Sjöberg O, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis- a prospective follow-up to 7 years of age. Allergy 2000;55:240-5.
  • Illi S, von Mutius E, Lau S, Nickel R, Grüber C, Niggeman B, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 2004;113:925-31.
  • Ballardini N, Kull I, Lind T, Hallner E, Almqvist C, Östblom E, et al. Development and comorbidity of eczema, asthma and rhinitis to age 12-data from the BAMSE birth cohort. Allergy 2012;67: 537-44.
  • von Kobyletzky L, Svensson A, Apfelbacher C, Schmitt J. Factors that predict remission of ınfant atopic dermatitis: A systematic review. Acta Derm Venereol 2015;95:389-94.
  • Ohshima Y, Yamada A, Hiraoka M, Katamura K, Ito S, Hirao T et al. Early sensitization to house dust mite is a major risk factor for subsequent development of bronchial asthma in Japanese infants with atopic dermatitis: Results of a 4-year followup study. Ann Allergy Asthma Immunol 2002;89:265-70.
  • Burrows D, Penman RWB. Prognosis of the eczema-asthma syndrome. Brit Med J 1960;2:825-8.

Two-Year Follow-up Results of Patients with Atopic Dermatitis

Year 2016, Volume: 10 Issue: 2, 120 - 125, 01.06.2016

Abstract

Objective: Atopic dermatitis (AD) is the most frequent inflammatory skin disease in childhood. Atopic dermatitis, as the first manifestation of atopic march may continue as asthma and allergic rhinitis. The aim of this study was to evaluate the early prognosis of AD in children.Material and Methods: Children who were diagnosed with AD before three years old between March 2009 and January 2012, and were followed for at least 2 years in the Pediatric Allergy Department of our tertiary hospital were enrolled in this study. Persistence of AD symptoms and development of asthma and/or allergic rhinitis were explored. Results: One hundred and four patients (59 male, 45 female) were included in the study. Atopic dermatitis persisted in 14 (13.5%) patients. Fourteen patients (13.5%) developed allergic rhinitis and 16 (15.4%) patients developed asthma. Food allergy was found to be a risk factor for persistence of AD lesions (OR (5.1) CI (1.4-18.3) (p=0.011).The presence of parental asthma (OR (6.2) (1.4-27.6) p=0,015) and persistence of AD lesions (OR (7.2) (1.7-34.9) p=0.007) were found to be risk factors for the development of asthma and/or allergic rhinitis.Conclusion: Persistence of atopic dermatitis and development of asthma and/or allergic rhinitis were significantly lower in our study group than in the literature. Long-term follow-up of patients with AD is required

References

  • Bogunıewicz M, Leung DYM. Atopic Dermatitis. In: Adkinson NF, Bochner BS, Burks AW, Busse WW, Holgate ST, Lemanske RF, O’Hehir RE (eds). Middleton’s Allergy Principles and Practice. 8th ed. USA: Elsevier Saunders, 2014: 540-64.
  • Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol 1980;92:44-7.
  • Oranjie AP. Practical issues on interpretation of scoring of atopic dermatitis: SCORAD index, objective SCORAD, patient-oriented SCORAD and three item severity score. Curr Probl Dermatol 2011;41:149-55.
  • GINA. http://www.ginasthma.com. 2014. Son ulaşılma tarihi: 4 Haziran 2014.
  • Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2) LEN and Aller Gen. Allergy 2008;86:8-160.
  • nın devam etme ihtimalini 5 kat arttırıyordu.
  • Linna O, Kokkonen J, Lahtela P, Tammela O. Ten- year prognosis for generalized infantile eczema. Acta Paediatr 1992;81:1013-6.
  • Kissling S, Wüthrich B. Follow-up of atopic dermatitis after early childhood. Hautarzt 1993;44:569-73.
  • Gustafsson D, Sjöberg O, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis- a prospective follow-up to 7 years of age. Allergy 2000;55:240-5.
  • Illi S, von Mutius E, Lau S, Nickel R, Grüber C, Niggeman B, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 2004;113:925-31.
  • Ballardini N, Kull I, Lind T, Hallner E, Almqvist C, Östblom E, et al. Development and comorbidity of eczema, asthma and rhinitis to age 12-data from the BAMSE birth cohort. Allergy 2012;67: 537-44.
  • von Kobyletzky L, Svensson A, Apfelbacher C, Schmitt J. Factors that predict remission of ınfant atopic dermatitis: A systematic review. Acta Derm Venereol 2015;95:389-94.
  • Ohshima Y, Yamada A, Hiraoka M, Katamura K, Ito S, Hirao T et al. Early sensitization to house dust mite is a major risk factor for subsequent development of bronchial asthma in Japanese infants with atopic dermatitis: Results of a 4-year followup study. Ann Allergy Asthma Immunol 2002;89:265-70.
  • Burrows D, Penman RWB. Prognosis of the eczema-asthma syndrome. Brit Med J 1960;2:825-8.
There are 14 citations in total.

Details

Other ID JA75PJ68DR
Journal Section Research Article
Authors

Emine Vezir This is me

Murat Çapanoğlu This is me

Emine Dibek Mısırlıoğlu This is me

Tayfur Giniş This is me

Ayşenur Kaya This is me

Ersoy Civelek This is me

Can Naci Kocabaş This is me

Publication Date June 1, 2016
Submission Date June 1, 2016
Published in Issue Year 2016 Volume: 10 Issue: 2

Cite

Vancouver Vezir E, Çapanoğlu M, Mısırlıoğlu ED, Giniş T, Kaya A, Civelek E, Kocabaş CN. Two-Year Follow-up Results of Patients with Atopic Dermatitis. Türkiye Çocuk Hast Derg. 2016;10(2):120-5.


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