Abstract
Amaç: Tip 1 diyabetes mellitus (DM) çocukluk yaş grubunda sık görülen, pankreasın beta hücrelerinin tahrip olması sonucu gelişen insülopeni ve hiperglisemi ile karakterize kronik metabolik bir hastalıktır. Çalışmada, Tip 1 DM’lihastaların klinik ve laboratuvar bulgularının değerlendirilmesi ve bulguların literatür eşliğinde tartışılması amaçlanmıştır.Gereç ve Yöntemler: Bu çalışma 2010-2013 Ocak tarihleri arasında Pediatrik Endokrinoloji Kliniğinde takip edilen, Tip 1 DM’li 162 hastanın değerlendirildiği tanımlayıcı kesitsel bir araştırmadır.Bulgular: Çalışmamıza 162 hasta dahil edildi (Yaş ortalaması 12.3 ±4.2 yıl). Olguların ortalama diyabet süresi 3.9±2.3 yıl, son 1 yıldaki ortalama Hba1c değerleri%9.74 ± 2.5’di. Tip 1 DM’ye ek olarak olguların % 6.7’sinde (n=11) çölyak hastalığı , %18.52’inde (n=30) de otoimmüntiroid hastalığı mevcuttu. Olguların %9.2’sinde (n=15) hipertansiyon, %7. 4’ünde (n=12) dislipidemi saptandı. Mikrovasküler komplikasyon olarak % 6.1’inde (n=10) 24 saatlik idrarda mikroalbüminüri, %15.4’ünde (n=25) EMG’de sinir ileti hızında yavaşlama tespit edildi.Sonuç: Tip 1 DM’li hastaların izleminde eşlik edebilecek otoimmün hastaların tespiti ve diyabete bağlı gelişebilecek komplikasyonların erken dönemde saptanması ve koruyucu önlemlerin alınması hastaların hayat kalitesinin arttırılması açısından önemlidir.
References
- Sperling MA. Diabetes Mellitus. In: Sperling MA (ed). Pediatric Endocrinology. 2nd ed. Philadelphia: Saunders, Elsevier Science, 2002:323-66.
- Boucher BJ. Thyroid disease in young diabetics. Lancet 1982;2:774-5.
- National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114:555-76.
- Norris A, Wolfsdorf J. Diabetes Mellitus. In: Brook CGD (ed). Clinical Pediatric Endocrinology. 4th ed. USA: Blackwell Publishing, 2005:436-73.
- Coskun T. Hiperlipoproteinemili hastaların uzun sureli izlemi. Katkı Pediatri Dergisi 1999;20:506–35.
- Bemben DA, Hamm RM, Morgan L, Winn P, Davis A, Barton E. Thyroid disease in the elderly. Part 2. Predictability of subclinical hypothyroidism. J Fam Pract 1994;38:583-8.
- Newhook LA, Curtis J, Hagerty D, Grant M, Paterson AD, Crummel C, et al. High incidence of childhood type 1 diabetes in the Avalon Peninsula, Newfoundland, Canada. Diabetes Care 2004; 27: 885-8.
- Cordell HJ, Todd JA. Multi factorial inheritance in type 1 diabetes. Trends Genet 1995;11: 499–504.
- Fiallo-Scharer R, Eisenbarth GS. Pathophysiology of insulin- dependent diabetes. In: Pescovitz OH, Eugster EA (eds). Pediatric Endocrinology. 1st edition. Philadelphia (USA): Lippincott Williams and Wilkins, 2004:411-26.
- Haller MJ, Atkinson MA, Schatz D. Type 1 diabetes mellitus: Etiology, presentation, and management. Pediatr Clin North Am 2005;52:1553-78.
- Saka HN. Diabetes Mellitus. In: Günöz H, Öcal G, Yordam N, Kurtoğlu S (eds). Pediatrik Endokrinoloji. 1. Baskı. Ankara: Pediatrik Endokrinoloji ve Oksoloji Derneği, 2003:415-55.
- Green A, Gale EA, Patterson CC. Incidence of childhood-onset insulin-dependent diabetes mellitus: The EURODIAB ACE study. Lancet 1992;339:905-9.
Abstract
Objective: Type 1 diabetes mellitus (DM) is a chronic metabolic disease of childhood characterized by insulin insufficiency and hyperglycemia due to the destruction of the beta cells of the pancreas. The aim of this study was to determine the laboratory and clinical characteristics of patients with type 1 diabetes mellitus and to compare the findings with the literature.Material and Methods: This is a descriptive study of 162 patients with type 1 diabetes mellitus followed by the Pediatric Endocrinology department between January 2010 and 2013.results: A total of 162 patients were included in this study (mean age, 12. 3 ±4. 2 years). The mean duration of diabetes was 3.89 ± 2.3 years and mean HbA1c was 2.5 ± 9.74%. In addition to Type 1 DM, 6.7% of cases (n = 11) had celiac disease and 18.52% of the cases (n = 30) had autoimmune thyroid disease. Hypertension was present in 9.2% of the cases (n = 15) while 7.4% (n = 12) had dyslipidemia. We found had 24-hour urine microalbuminuria in 6.1% of the cases (n = 10) and decreased EMG nerve conduction velocity in 15.4% of the cases (n =25).conclusion: It is important to detect any concurrent autoimmune disorders and diabetes-related potential complications in the early stages and to take preventive measures to increase the quality of life during follow-up of patients with Type 1 DM
References
- Sperling MA. Diabetes Mellitus. In: Sperling MA (ed). Pediatric Endocrinology. 2nd ed. Philadelphia: Saunders, Elsevier Science, 2002:323-66.
- Boucher BJ. Thyroid disease in young diabetics. Lancet 1982;2:774-5.
- National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114:555-76.
- Norris A, Wolfsdorf J. Diabetes Mellitus. In: Brook CGD (ed). Clinical Pediatric Endocrinology. 4th ed. USA: Blackwell Publishing, 2005:436-73.
- Coskun T. Hiperlipoproteinemili hastaların uzun sureli izlemi. Katkı Pediatri Dergisi 1999;20:506–35.
- Bemben DA, Hamm RM, Morgan L, Winn P, Davis A, Barton E. Thyroid disease in the elderly. Part 2. Predictability of subclinical hypothyroidism. J Fam Pract 1994;38:583-8.
- Newhook LA, Curtis J, Hagerty D, Grant M, Paterson AD, Crummel C, et al. High incidence of childhood type 1 diabetes in the Avalon Peninsula, Newfoundland, Canada. Diabetes Care 2004; 27: 885-8.
- Cordell HJ, Todd JA. Multi factorial inheritance in type 1 diabetes. Trends Genet 1995;11: 499–504.
- Fiallo-Scharer R, Eisenbarth GS. Pathophysiology of insulin- dependent diabetes. In: Pescovitz OH, Eugster EA (eds). Pediatric Endocrinology. 1st edition. Philadelphia (USA): Lippincott Williams and Wilkins, 2004:411-26.
- Haller MJ, Atkinson MA, Schatz D. Type 1 diabetes mellitus: Etiology, presentation, and management. Pediatr Clin North Am 2005;52:1553-78.
- Saka HN. Diabetes Mellitus. In: Günöz H, Öcal G, Yordam N, Kurtoğlu S (eds). Pediatrik Endokrinoloji. 1. Baskı. Ankara: Pediatrik Endokrinoloji ve Oksoloji Derneği, 2003:415-55.
- Green A, Gale EA, Patterson CC. Incidence of childhood-onset insulin-dependent diabetes mellitus: The EURODIAB ACE study. Lancet 1992;339:905-9.
Details
| Other ID | JA68GC63EU |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 1, 2015 |
| Submission Date | December 1, 2015 |
| Published in Issue | Year 2015 Volume: 9 Issue: 4 |
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