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Lenfadenomegalisi Olan 223 Çocuk Hastanın Prospektif Değerlendirilmesi

Year 2015, Volume: 9 Issue: 3, 161 - 166, 01.08.2015

Abstract

Amaç: Lenfadenomegali çocuklarda sık karşılaşılan bir bulgudur, çocuğun ailesi ve izleyen hekim için bazen zaman sıkıntılı bir sürece neden olur. Lenfadenomegalisi olan çocukların klinik ve laboratuvar bulgularını ileriye dönük olarak değerlendirilmesi amaçlandı.Gereç ve Yöntemler: 1 Eylül 2013-31 Ağustos 2014 tarihleri arasında Eskişehir Devlet Hastanesi Çocuk Hematolojisi ve Onkolojisi Polikliniğine lenfadenomegali nedeni ile yönlendirilen yaşları 0.3-17.5 yıl arasında 223 çocuk hasta dahil edildi.Bulgular: Olguların 64’ünde (%36) 4 haftadan daha uzun süredir büyümüş lenf nodları mevcuttu, bunlardan 17’sinde (%8) 3 cm’den daha büyüktü, 9 (%4) olguda eksiyonel biyopsi yapıldı, 6 (%2.7) hastada maliyn nedenler saptandı. Maliyn hastalık tanısı alan olgularda yaş ortalaması 13.3 ± 3.3 yıl (değer aralığı 8.7-17 yıl) ve ortalama lenfadenomegali çapı 3.1 ± 1 cm, bu değerler beniyn grupta 6.6 ± 4.2 yıl ( değer aralığı 0.3-17.5 yıl) ve 1.6 ± 0.9 cm olarak saptandı. Beniyn durum arz eden 208 hasta ortalama 2 ± 3 ay (1-12 ay) takip edildi, bunların içinde maliynite saptanan olmadı.Sonuç: Çocukluk çağı lenf nodu büyümelerinde tanı yönünden asıl olan yaklaşım tarzı klinik ve muayene bulgularıdır.

References

  • Ferrer R. Lymphadenopathy: Differential diagnosis and evaluation. Am Fam Physician 1998;58:1313-20.
  • Oguz A, Karadeniz C, Temel EA, Citak EC, Okur FV. Evaluation of peripheral lymphadenopathy in children. Pediatr Hematol Oncol 2006;23:549-61.
  • Kelly CS, Kelly RE Jr. Lymphadenopathy in children. Pediatr Clin North Am 1998;45:875-88.
  • Knight PJ, Mulne AF, Vassy LE. When is lymph node biopsy indicated in children with enlarged peripheral nodes? Pediatrics 1982;69:391-6.
  • Öksüz RYÇ, Dağdemir A, Acar S, Elli M, Öksüz M. Çocukluk çağı periferik lenfadenomegalili olguların retrospektif değerlendirilmesi. OMÜ Tıp Dergisi 2008;25:94–101.
  • Citak EC, Koku N, Demirci M, Tanyeri B, Deniz H: A retrospective chart review of evaluation of the cervical lymphadenopathies in children. Auris Nasus Larynx 2011;38:618–21.
  • Leung AK, Robson WL. Childhood cervical lymphadenopathy. J Pediatr Health Care 2004;18:3-7.
  • Dulin MF, Kennard TP, Leach L, Williams R. Management of cervical lymphadenitis in children. Am Fam Physician 2008;78:1097-8.
  • Genç DB. Approach to childhood lymphadenopathy. Journal of Pediatric Research 2014;1:6-12.
  • Bazemore AW, Smucker DR. Lymphadenopathy and malignancy. Am Fam Physician 2002;66:2103-11.
  • Reiter A, Ferrando AA. Lympadenopathy. In: Orkin SH, Fisher DE, Look AT, Lux SE, Gingsburg D, Nathan DG (eds). Oncology of Infancy and Childhood. 1st ed. Philadelphia: Saunders Elsevier, 2009:485-8.
  • Çalkavur Ş, Yalaz M, Kütükçüler N, Özkınay F, Kansoy S, Kültürsay N. Omenn sendromlu bir olgu. Türkiye Çocuk Hast Derg 2013;1: 40-3.
  • Barton LL. Childhood cervical adenitis. Am Fam Physician 1984; 29:163–6.
  • Adesuwa Olu-Eddo N, Egbagbe EE. Peripheral lymphadenopathy in Nigerian children. Niger J Clin Pract 2006;9:134-8.
  • Hafez NH, Tahoun NS. Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy. J Egypt Natl Canc Inst 2011;23:105-14.
  • Agrawal H, Gonsai RN, Singal S, Goswami HM. Fine needle aspiration (fnac) as a diagnostic tool ın paediatric lymphadenopathy. Int J Cur Res Rev 2014;6:39-43.
  • Yarış N, Çakır M, Sözen E, Cobanoglu U. Analysis of children with peripheral lymphadenopathy. Clin Pediatr 2006;45:544-9.

Prospective Evaluation of 223 Children with Lymphadenomegaly

Year 2015, Volume: 9 Issue: 3, 161 - 166, 01.08.2015

Abstract

Objective: A palpable lymph node in the physical examination may pose a distressing situation for both the parents and the physician who is following the child. We aimed to prospectively document the value of clinical and laboratory findings in children with lymphadenomegaly.Material and Methods: Two hundred twenty-three children aged 0.3 to 17.5 years with lymphadenomegaly diagnosed during general physical examinations and referred to Eskisehir State Hospital Pediatric Hematology/Oncology outpatient clinic for the first time between 1 September 2013 and 31 August 2014 were included in the study.Results: Seventy-one patients (32%) were female. Benign causes were detected in 217 (97.3%) cases and malignant causes were detected in 6 (2.7%) cases of total 223 cases. The average age of the patients that were diagnosed with malignant disease was 13.3 ± 3.3 years (range 8.7-17 years) and the mean lymphadenomegaly diameter was 3.1 ± 1 cm. The average age of the cases diagnosed with benign disease was 6.6 ± 4.2 years and the mean lymphadenomegaly diameter was 1.6 ± 0.9 cm. The median follow-up for 208 of 223 evaluable patients was 2 months (range, 1 to 12 months) in patients with a benign clinical picture and no patient had a malignant tumor. conclusion: Primary diagnostic evaluation is based mainly on clinical and physical examinations in children with lymph node enlargement

References

  • Ferrer R. Lymphadenopathy: Differential diagnosis and evaluation. Am Fam Physician 1998;58:1313-20.
  • Oguz A, Karadeniz C, Temel EA, Citak EC, Okur FV. Evaluation of peripheral lymphadenopathy in children. Pediatr Hematol Oncol 2006;23:549-61.
  • Kelly CS, Kelly RE Jr. Lymphadenopathy in children. Pediatr Clin North Am 1998;45:875-88.
  • Knight PJ, Mulne AF, Vassy LE. When is lymph node biopsy indicated in children with enlarged peripheral nodes? Pediatrics 1982;69:391-6.
  • Öksüz RYÇ, Dağdemir A, Acar S, Elli M, Öksüz M. Çocukluk çağı periferik lenfadenomegalili olguların retrospektif değerlendirilmesi. OMÜ Tıp Dergisi 2008;25:94–101.
  • Citak EC, Koku N, Demirci M, Tanyeri B, Deniz H: A retrospective chart review of evaluation of the cervical lymphadenopathies in children. Auris Nasus Larynx 2011;38:618–21.
  • Leung AK, Robson WL. Childhood cervical lymphadenopathy. J Pediatr Health Care 2004;18:3-7.
  • Dulin MF, Kennard TP, Leach L, Williams R. Management of cervical lymphadenitis in children. Am Fam Physician 2008;78:1097-8.
  • Genç DB. Approach to childhood lymphadenopathy. Journal of Pediatric Research 2014;1:6-12.
  • Bazemore AW, Smucker DR. Lymphadenopathy and malignancy. Am Fam Physician 2002;66:2103-11.
  • Reiter A, Ferrando AA. Lympadenopathy. In: Orkin SH, Fisher DE, Look AT, Lux SE, Gingsburg D, Nathan DG (eds). Oncology of Infancy and Childhood. 1st ed. Philadelphia: Saunders Elsevier, 2009:485-8.
  • Çalkavur Ş, Yalaz M, Kütükçüler N, Özkınay F, Kansoy S, Kültürsay N. Omenn sendromlu bir olgu. Türkiye Çocuk Hast Derg 2013;1: 40-3.
  • Barton LL. Childhood cervical adenitis. Am Fam Physician 1984; 29:163–6.
  • Adesuwa Olu-Eddo N, Egbagbe EE. Peripheral lymphadenopathy in Nigerian children. Niger J Clin Pract 2006;9:134-8.
  • Hafez NH, Tahoun NS. Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy. J Egypt Natl Canc Inst 2011;23:105-14.
  • Agrawal H, Gonsai RN, Singal S, Goswami HM. Fine needle aspiration (fnac) as a diagnostic tool ın paediatric lymphadenopathy. Int J Cur Res Rev 2014;6:39-43.
  • Yarış N, Çakır M, Sözen E, Cobanoglu U. Analysis of children with peripheral lymphadenopathy. Clin Pediatr 2006;45:544-9.
There are 17 citations in total.

Details

Other ID JA87RA83MA
Journal Section Research Article
Authors

Ali Ayçiçek This is me

Bahattin Erdoğan This is me

Publication Date August 1, 2015
Submission Date August 1, 2015
Published in Issue Year 2015 Volume: 9 Issue: 3

Cite

Vancouver Ayçiçek A, Erdoğan B. Prospective Evaluation of 223 Children with Lymphadenomegaly. Türkiye Çocuk Hast Derg. 2015;9(3):161-6.


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