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Farklı Klinik Bulgular Gösteren Glukoz-6-Fosfat Dehidrogenaz Enzim Eksikliği Olguları: Semptomsuz Baba ve Hemolitik Anemili Kızı

Year 2015, Volume: 9 Issue: 3, 0 - 0, 01.08.2015

Abstract

Glukoz-6-fosfat dehidrogenaz (G6PD), eritrositlerde pentoz monofosfat yolunda görev alan, aynı zamanda hücreleri oksidatif stresten koruyan bir enzimdir.G6PD eksikliğinin en sık görülen klinik belirtileri yenidoğan sarılığı ve genellikle ilaçlar, enfeksiyonlar ve bazı gıdalar gibi eksojen ajanlar tarafından tetiklenen akut hemolitik anemidir. Bazı G6PD varyantları doğumsal non-sferositik hemolitik anemiye neden olabilirler. X’e bağlı resesif kalıtım göstermektedir. Hastalık erkeklerde ve homozigot kızlarda ortaya çıkar.Yirmi altı aylık kız olgumuz bakla yeme sonrasında göz akında sararma ve huzursuzluk şikayeti ile başvurdu. G6PD enzim eksikliği tanısı konulan hastanın babasında da GGPDH enzim düzeyi düşük saptandı. Ancak, baba defalarca bakla yeme öyküsü olmasına karşın herhangi bir hemolitik tablo gelişmemişti. Bu olgu, G6PD enzim eksikliğinin farklı cinsiyetlerde farklı klinik seyirlerinin olabileceğini vurgulamak amacı ile sunulmuştur.

References

  • Luzatto L, Paggi V. Glucose 6 phosphate dehydrogenase deficiency. In: Orkin SH, Nathan DG (eds). Nathan and Oski’s Hematology Infancy and Childhood. 7th ed. Philadelphia: Saunders Elsevier, 2009:883-907.
  • Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet 2008;371:64-74.
  • Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis. Blood Cells Mol Dis 2009;42:267-78.
  • Altay Ç, Gümrük F. Red cell glucose-6-phosphate dehydrogenase deficiency in Turkey. Turk J Hematol 2008; 25:1-7.
  • Minucci A, Moradkhani K, Hwang MJ, Zuppi C, Giardina B, Capoluongo E: Glucose-6-phosphate dehydrogenase (G6PD) mutations database: Review of the “old” and update of the new mutations. Blood Cells Mol Dis 2012;48:154-65.
  • Mason PJ, Bautista JM, Gilsanz F. G6PD deficiency: The genotype- phenotype association. Blood Rev 2007;21:267-83.
  • Manco L, Pereira J, Relvas L, Rebelo U, Crisóstomo AI, Bento C, Ribeiro ML. Chronic hemolytic anemia is associated with a new glucose-6-phosphate dehydrogenase in-frame deletion in an older woman. Blood Cells Mol Dis 2011;15:288-93.
  • Peters AL, Van Noorden CJ. Glucose-6-phosphate dehydrogenase deficiency and malaria: Cytochemical detection of heterozygous G6PD deficiency in women. J Histochem Cytochem 2009;57:1003- 11.
  • Nance WE. Turner’s syndrome, twinning, and an unusual variant of glucose-6-phosphate dehydrogenase. Am J Hum Genet 1964;16:380-92.

Glucose-6-Phosphate Dehydrogenase Deficiency Cases with Different Clinical Findings: Daughter with Hemolytic Anemia and Asymptomatic Father

Year 2015, Volume: 9 Issue: 3, 0 - 0, 01.08.2015

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme included in the pentose phosphate pathway with a cellular protective effect against oxidative stress.The most frequent clinical manifestations of G6PD deficiency are neonatal jaundice and acute hemolytic anemia, which is usually triggered by an exogenous agent such as drugs, infections and certain nutrients. Some G6PD variants cause chronic hemolysis, leading to congenital non-spherocytic hemolytic anemia. The disorder is inherited by X-linked transmission. Homozygote females and males are the cases at risk for G6PD deficiency.A 26-month-old girl presented with hemolytic anemia after eating broad beans. She was diagnosed with G6PD deficiency and interestingly the G6DP level was also decreased in her father. There was no history of hemolytic anemia in the father despite multiple exposure to broad beans. We aimed to underline the different types of clinical expressions of G6PD deficiency in different genders by presenting this case report

References

  • Luzatto L, Paggi V. Glucose 6 phosphate dehydrogenase deficiency. In: Orkin SH, Nathan DG (eds). Nathan and Oski’s Hematology Infancy and Childhood. 7th ed. Philadelphia: Saunders Elsevier, 2009:883-907.
  • Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet 2008;371:64-74.
  • Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis. Blood Cells Mol Dis 2009;42:267-78.
  • Altay Ç, Gümrük F. Red cell glucose-6-phosphate dehydrogenase deficiency in Turkey. Turk J Hematol 2008; 25:1-7.
  • Minucci A, Moradkhani K, Hwang MJ, Zuppi C, Giardina B, Capoluongo E: Glucose-6-phosphate dehydrogenase (G6PD) mutations database: Review of the “old” and update of the new mutations. Blood Cells Mol Dis 2012;48:154-65.
  • Mason PJ, Bautista JM, Gilsanz F. G6PD deficiency: The genotype- phenotype association. Blood Rev 2007;21:267-83.
  • Manco L, Pereira J, Relvas L, Rebelo U, Crisóstomo AI, Bento C, Ribeiro ML. Chronic hemolytic anemia is associated with a new glucose-6-phosphate dehydrogenase in-frame deletion in an older woman. Blood Cells Mol Dis 2011;15:288-93.
  • Peters AL, Van Noorden CJ. Glucose-6-phosphate dehydrogenase deficiency and malaria: Cytochemical detection of heterozygous G6PD deficiency in women. J Histochem Cytochem 2009;57:1003- 11.
  • Nance WE. Turner’s syndrome, twinning, and an unusual variant of glucose-6-phosphate dehydrogenase. Am J Hum Genet 1964;16:380-92.
There are 9 citations in total.

Details

Other ID JA58HH83CR
Journal Section Research Article
Authors

Barış Malbora This is me

Serkan Bilge Koca This is me

Hikmet Gülşah Tanyıldız This is me

Publication Date August 1, 2015
Submission Date August 1, 2015
Published in Issue Year 2015 Volume: 9 Issue: 3

Cite

Vancouver Malbora B, Koca SB, Tanyıldız HG. Glucose-6-Phosphate Dehydrogenase Deficiency Cases with Different Clinical Findings: Daughter with Hemolytic Anemia and Asymptomatic Father. Türkiye Çocuk Hast Derg. 2015;9(3).


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