BibTex RIS Cite

Juvenil İdiopatik Artritli Hastalarda Metabolik Sendrom Durumunun Değerlendirilmesi

Year 2015, Volume: 9 Issue: 1, 39 - 43, 01.04.2015

Abstract

Amaç: Çalışmamızda, juvenil idiopatik artritli (JİA) çocuklarda hastalığın seyrinin ve kullanılan ilaçların metabolik sendrom (MetS) görülme sıklığı üzerine olan etkisini değerlendirmeyi amaçladık.Gereç ve Yöntemler: Çalışmamıza International League Against Rheumatism (ILAR) teşhis kriterlerine göre JİA tanısı almış, ek kronik hastalığı olmayan 10 ile 16 yaş arası 67 hasta alındı. Çalışmaya alınan olgularda MetS tanısı, Uluslararası Diyabet Federasyonu (IDF) tarafından yaş gruplarına göre belirlenen MetS tanı kriterlerine göre konuldu.Bulgular: Hastaların %38.8’i entesit ilişkili JİA, %38.8’i oligoartiküler JİA, %13.4’ü poliartiküler JİA, %8.9’u sistemik JİA olarak belirlendi. Hasta ailelerinin %54’ünde hipertansiyon (HT), %27’inde tip 2 diyabetes mellitus (T2DM), %39’unda obezite, %13’ünde inme, %36’sında ateroskleroz ve annelerin %4’ünde gestasyonel diabetes mellitus (GDM) öyküsü vardı. JİA’lı hastaların %4,47’sinde MetS varlığı belirlendi. Hastaların %9’unda vücut kitle indeksi (VKİ)>95p, %7’sinde HT, %6’sında trigliserid (TG)≥150 mg/dl, %24’ünde yüksek dansiteli lipoprotein (HDL)≤40 mg/dl, %7’sinde açlık kan şekeri (AKŞ) ≥100 mg/dl, %16’sında stria, %7’sinde akantozis nigrikans belirlendi. JİA’lı hastaların %16’sının non-steroid anti inflamatuvar ilaç (NSAİİ), %1’inin metotreksat (MTX), %10’unun salazosulfapyridine (SASP), %7’sinin glukokortikoid (GC)+SASP, %18’inin MTX+GC, %7’sinin MTX+SASP, %12’sinin MTX+SASP+GC, %1’inin anti-tümör nekrozis faktöralfa (Anti-TNF-α)+MTX+GC, %1’inin Anti-TNF-alfa+MTX+GC+SASP kullandığı belirlendi.Sonuç: Çalışmamızda, JİA’lı hastalarda hastalığın seyri ve kullanılan ilaçların MetS sıklığını arttırmadığı belirlendi. JİA’lı hastalarda tedavi seçeneklerinin iyi bilinmesi ve gerektiği durumlarda alternatif tedavilerin kullanılması halinde MetS ve komponentlerine bağlı komplikasyonların önemli ölçüde azalacağı belirlendi. Bu hastalarda, MetS üzerine yapılan çalışmaların artması hastalığın tanımlanması ve yönetimi açısından daha fazla bilgi sahibi olmamızı sağlayacaktır.

References

  • Zanette Cde A, Machado SH, Brenol JC, Xavier RM. Metabolic syndrome and juvenile idiopathic arthritis. Rev Bras Reumatol ;50:190-204. Chen W, Berenson GS. Metabolic syndrome: Defi nition and prevalence in children. J Pediatr 2007;83:1-2.
  • Strufaldi MW, Silva EM, Puccini RF. Metabolic syndrome among prepubertal Brazilian schoolchildren. Diabetes Vasc Dis Res ;5:291-7. Bundak R, Furman A, Gunoz H, Darendeliler F, Bas F, Neyzi O. Body mass index references for Turkish children. Acta Paediatr ;95:194-8. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114:555-73.
  • Zimmet P, Alberti KGMM, Kaufman F, Tajima N, Silink M, Arslanian S, et al. IDF Consensus Group. The metabolic syndrome in children and adolescents-an IDF consensus report. Pediatric Diabetes ;8:299-306. rasyonları arasındaki ilişkiliyi göstermişlerdir. MetS’li hastaların Tablo IV: Metabolik sendrom tanısı alan olgular.   MetS tanısı alan olgular VKİ>95p+TG≥150mg/dl+AKŞ≥100mg/ (%1.49) dl+HT VKİ>95p+TG≥150mg/dl+HT (%1.49) VKİ>95p+TG≥150mg/dl+HDL≤40mg/ (%1.49) dl+HT

Juvenile Idiopathic Arthritis Evaluation of the Metabolic Syndrome Incidence in Patients with

Year 2015, Volume: 9 Issue: 1, 39 - 43, 01.04.2015

Abstract

Objective: In our study we aimed to evaluate the effects of natural course of juvenile idiopathic arthritis (JIA) in children and drugs used for the treatment on the occurence frequency of metabolic syndrome.Material and Methods: Our study was conducted on 67 patients who were diagnosed according to the International League Against Rheumatism (ILAR) criteria between the ages of 10 and 16 without any accompanying chronic diseases. In the cases included in this study, metabolic syndrome (MetS) was diagnosed according to the criteria defi ned for the metabolic syndrome by International Diabetes Federation (IDF) based upon age groups.Results: 38.8% of patients were diagnosed with enthesitis-related JIA, 38.8% with oligoarticular, 13.4% with polyarticular and 8.9% with systemic JIA. In 54% of the patients’ parents, hypertension; in 27% type 2 diabetes mellitus (T2DM), in 39% obesity, in 13% stroke, in 36% atherosclerosis and fi nally in 4% of the mothers, gestational diabetes (GDM) were found to be present. MetS was found in 4.47% of the patients with JIA. In 9% of the patients BMI was >95p; in 7% hypertension was present; in 6% TG was ≥150 mg/dl; in 24% HDL-C was ≤40 mg/dl; in 7% Fasting Blood Glucose (FBG) was ≥100 mg/dl; in 16% there was strias, and fi nally in 7%, acanthosis nigricans were found. It was determined that 16% of the patients with JIA use NSAID; 1% use MTX; 10% use SASP; 7% use GC+SASP; 18% use MTX+GC; 7% use MTX+SASP; 12% use MTX+SASP+GC; 1% use Anti-TNF-α+MTX+GC; and %1 use Anti-TNFalfa+MTX+GC+SASP. Conclusion: In our study, it was determined that the continuation of the disease and the medicines used do not increase the density of MetS in the patients with JIA. It was determined that MetS and the complications dependent on its complications can decrease signifi cantly, provided that the alternatives of treatment are known well and these alternative treatments are used in patients with JIA, if necessary. In these patients, to increase the studies on MetS will help us be more informed about the identifi cation and management of the disease

References

  • Zanette Cde A, Machado SH, Brenol JC, Xavier RM. Metabolic syndrome and juvenile idiopathic arthritis. Rev Bras Reumatol ;50:190-204. Chen W, Berenson GS. Metabolic syndrome: Defi nition and prevalence in children. J Pediatr 2007;83:1-2.
  • Strufaldi MW, Silva EM, Puccini RF. Metabolic syndrome among prepubertal Brazilian schoolchildren. Diabetes Vasc Dis Res ;5:291-7. Bundak R, Furman A, Gunoz H, Darendeliler F, Bas F, Neyzi O. Body mass index references for Turkish children. Acta Paediatr ;95:194-8. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114:555-73.
  • Zimmet P, Alberti KGMM, Kaufman F, Tajima N, Silink M, Arslanian S, et al. IDF Consensus Group. The metabolic syndrome in children and adolescents-an IDF consensus report. Pediatric Diabetes ;8:299-306. rasyonları arasındaki ilişkiliyi göstermişlerdir. MetS’li hastaların Tablo IV: Metabolik sendrom tanısı alan olgular.   MetS tanısı alan olgular VKİ>95p+TG≥150mg/dl+AKŞ≥100mg/ (%1.49) dl+HT VKİ>95p+TG≥150mg/dl+HT (%1.49) VKİ>95p+TG≥150mg/dl+HDL≤40mg/ (%1.49) dl+HT
There are 3 citations in total.

Details

Other ID JA65GF83FF
Journal Section Research Article
Authors

Nurhayat Yakut This is me

Kahraman Yakut This is me

Müferet Ergüven This is me

Publication Date April 1, 2015
Submission Date April 1, 2015
Published in Issue Year 2015 Volume: 9 Issue: 1

Cite

Vancouver Yakut N, Yakut K, Ergüven M. Juvenile Idiopathic Arthritis Evaluation of the Metabolic Syndrome Incidence in Patients with. Türkiye Çocuk Hast Derg. 2015;9(1):39-43.


The publication language of Turkish Journal of Pediatric Disease is English.


Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.


The aim of the Turkish Journal of Pediatrics is to publish high-quality original research articles that will contribute to the international literature in the field of general pediatric health and diseases and its sub-branches. It also publishes editorial opinions, letters to the editor, reviews, case reports, book reviews, comments on previously published articles, meeting and conference proceedings, announcements, and biography. In addition to the field of child health and diseases, the journal also includes articles prepared in fields such as surgery, dentistry, public health, nutrition and dietetics, social services, human genetics, basic sciences, psychology, psychiatry, educational sciences, sociology and nursing, provided that they are related to this field. can be published.