Abstract
Son yıllarda normal demir metabolizmasının ve bununla ilişkili bozuklukların ortaya konulması hususunda çok önemli ilerlemeler kaydedilmiştir. Demir emilimi, enterositlerden ve makrofajlardan salınımında rol oynayan proteinlerin ve de en önemlisi hepsidin hormonunun keşfi sonucunda bu ilerlemeler kaydedilmiştir. Demir metabolizması bozuklukları, insanlarda en çok görülen hastalıklardandır. Bu derlemede normal demir metabolizması ile demir eksikliği bozuklukları ve demir birikimi bozukları incelenerek, literatürdeki son gelişmeler ışığında patofizyolojileri irdelenmiştir.
Keywords
References
- Camaschella C, Poggiali E. Inherited disorders of iron metabolism. Current Opinion in Pediatrics 2011;23:14-20.
- Manuel Munoz, Jose Ántonio Garcia-Erce, Angel Francisco Remacha. Disorders of iron metabolism. Part 1: Molecular basis of iron homoeostasis. J ClinPathol 2011;64:281-6.
- Muñoz M, García-Erce JA, Remacha ÁF. Disorders of iron metabolism. Part 2: Iron defi ciency and iron overload. J Clin Pathol 2011;64:287-96.
- Muñoz M, Villar I, García-Erce JA. An update on iron physiology. World J Gastroenterol 2009;15:4617-26.
- Evim MS, Baytan B, Güneş AM. Demir ve demir metabolizması. Güncel Pediatri 2012;10:65-9.
- Özbek N. Iron transport: From enterocyte to mitochondria. Turk J Hematol 2010;27:137-46.
Abstract
There has been major progress in the understanding of iron metabolism in recent years due to the discovery of proteins playing a role in iron absorption and its release from the enterocyte and macrophages. However the most important discovery was the identifi cation of hepcidin, currently considered to be the “iron hormone”. Disorders of iron homeostasis are among the most common disorders of humans. This review discusses normal iron metabolism together with iron defi ciency and iron overload disorders with recent insights into their pathophysiology in the latest literature
Keywords
References
- Camaschella C, Poggiali E. Inherited disorders of iron metabolism. Current Opinion in Pediatrics 2011;23:14-20.
- Manuel Munoz, Jose Ántonio Garcia-Erce, Angel Francisco Remacha. Disorders of iron metabolism. Part 1: Molecular basis of iron homoeostasis. J ClinPathol 2011;64:281-6.
- Muñoz M, García-Erce JA, Remacha ÁF. Disorders of iron metabolism. Part 2: Iron defi ciency and iron overload. J Clin Pathol 2011;64:287-96.
- Muñoz M, Villar I, García-Erce JA. An update on iron physiology. World J Gastroenterol 2009;15:4617-26.
- Evim MS, Baytan B, Güneş AM. Demir ve demir metabolizması. Güncel Pediatri 2012;10:65-9.
- Özbek N. Iron transport: From enterocyte to mitochondria. Turk J Hematol 2010;27:137-46.
Details
| Other ID | JA73KM23ZC |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | April 1, 2015 |
| Submission Date | April 1, 2015 |
| Published in Issue | Year 2015 Volume: 9 Issue: 1 |
The publication language of Turkish Journal of Pediatric Disease is English.
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