Abstract
Bruselloz, tüm dünyada ve ülkemizde yaygın olarak görülen önemli bir halk sağlığı sorunudur. Kesin tanısı, bakterinin kan ya da kemik iliği kültüründe üretilmesi olmasına rağmen; hastaların tanı almadan önce çeşitli antibiyotikleri kullanması ve kültür sonuçlarının geç öğrenilmesi nedeniyle, sıklıkla serolojik tanı yöntemlerine başvurulmaktadır. Brusella enfeksiyonunun serolojik tanısında en sık kullanılan serum aglütinasyon (Wright) testinde, prozon fenomeni nedeniyle yanlış negatif sonuçlar görülebilmektedir. Prozon fenomeni, antikor fazlalığı veya özgün olmayan serum faktörleri nedeniyle düşük dilüsyonlarda aglütinasyonun inhibe olmasıdır. Bu olgu, kuvvetle bruselloz düşünüldüğünde prozon fenomeninin akılda bulundurulması gerektiğini ve tanı konulmasında klinik şüpheciliğin önemini vurgulamak amacıyla sunulmuştur.
Keywords
References
- Corbel MJ. Brucellosis: An overview. Emerg Infect Dis 1997;3: 213-21.
- Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol 2007;25:188-202.
- Ciftdoğan DY, Bayram N, Vardar F. Brucellosis as a cause of fever of unknown origin in children admitted to a tertiary hospital in the Aegean region of Turkey. Vector-borne and Zoonotic Dis 2011;11:1037-40.
- Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med 2005; 352:2325-36.
- Arica V, Karakuş A, Arıca S, Tutanç M, Şilfeler İ, Motor V. Two cases of brucellosis with atypical maculopapuler rash recorded in siblings. J Infect Dis Immun 2011;3:165-8.
- Ayaslioglu E, Koçak M, Bozdogan O. A case of brucellosis presenting with widespread maculopapuler rash. Am J Dermatopathol 2009;31:687-90.
- Akcalı C, Savas L, Baba M, Turunc T, Seckin D. Cutaneous manifestations in brucellosis: A prospective study. Adv Ther 2007; 24:706-11.
- Milionis H, Christou L, Elisaf M. Cutaneous manifestations in brucellosis: Case report and review of the literature. Infection 2000;28:124-6.
Abstract
Brucellosis is an important public health problem that is seen commonly in our country and the world. Although the absolute diagnosis of brucellosis requires isolation of the bacterium from blood or bone marrow, serological methods are used frequently because of antibiotic use before the diagnosis and the fact that culture results may not become available for a long time. False negative results due to the prozone phenomenon may be seen in the serum agglutination test that is commonly used in the serological diagnosis of brucellosis. The inhibition of agglutination at low dilutions due to an excess of antibodies or to nonspecific serum factors is called the prozone phenomenon. This case is reported to draw attention to the prozone phenomenon that should be recognized when there is a strong suspicion of brucellosis and the importance of clinical suspicion in the diagnosis of this disorder
Keywords
References
- Corbel MJ. Brucellosis: An overview. Emerg Infect Dis 1997;3: 213-21.
- Mantur BG, Amarnath SK, Shinde RS. Review of clinical and laboratory features of human brucellosis. Indian J Med Microbiol 2007;25:188-202.
- Ciftdoğan DY, Bayram N, Vardar F. Brucellosis as a cause of fever of unknown origin in children admitted to a tertiary hospital in the Aegean region of Turkey. Vector-borne and Zoonotic Dis 2011;11:1037-40.
- Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med 2005; 352:2325-36.
- Arica V, Karakuş A, Arıca S, Tutanç M, Şilfeler İ, Motor V. Two cases of brucellosis with atypical maculopapuler rash recorded in siblings. J Infect Dis Immun 2011;3:165-8.
- Ayaslioglu E, Koçak M, Bozdogan O. A case of brucellosis presenting with widespread maculopapuler rash. Am J Dermatopathol 2009;31:687-90.
- Akcalı C, Savas L, Baba M, Turunc T, Seckin D. Cutaneous manifestations in brucellosis: A prospective study. Adv Ther 2007; 24:706-11.
- Milionis H, Christou L, Elisaf M. Cutaneous manifestations in brucellosis: Case report and review of the literature. Infection 2000;28:124-6.
Details
| Other ID | JA52ZD26SR |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | June 1, 2013 |
| Submission Date | June 1, 2013 |
| Published in Issue | Year 2013 Volume: 7 Issue: 1,EK |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
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