Abstract
Methemoglobin (MetHb), hemoglobin molekülündeki Fe+2’nin Fe+3 şeklinde okside formda olmasını tanımlar. Konjenital ya da edinsel olabilir. Edinsel methemoglobinemi yapan çok sayıda ajan bilinmektedir. Kan MetHb düzeyi %55’in üzerinde ise fatal seydedebilir. Acil müdahale gereklidir. Burada prilokaine bağlı methemoglobinemi gelişen 4 aylık bir erkek hasta sunulmuştur. Tedavide kullanılan metilen mavisi ile dramatik bir düzelme sağlanmış ve hayat kurtarıcı olmuştur.
References
- DeBaun MR, Vichinsky E. Hereditary methemoglobinemia (Chapter 462, Hemoglobinopathies). In: Nelson Textbook of Pediatrics. 18th edition, Behrman & Kliegman& Jenson; 2007:2032-33.
- Trapp L, Will J. Acquired methemoglobinemia revisited. Dent Clin North Am 2010;54:665-75.
- Benini D, Vino L, Fanos V. Acquired methemoglobinemia: A case report. Pediatr Med Chir 1998;20:411-13.
- Türkiye Çocuk Hast Derg/Turkish J Pediatr Dis / 2013; 2: 86-88
- Frey B, Kehrer B. Toxic methaemoglobin concentrations in premature infants after application of a prilocaine containing cream and peridural prilocaine. Eur J Pediatr 1999;158:785-88.
- Akbayram S, Akgün C, Doğan M, Gündogdu M, Caksen H, Faik Öner A. Acquired methemoglobinemia due to application of prilocaine during circumcision. J Emerg Med 2010. [Epub ahead of print]
- Guay J. Methemoglobinemia related to local anesthetics: A summary of 242 episodes. Anesth Analg 2009;108:837-45.
- Soeding P, Deppe M, Gehring H. Pulse-Oximetric measurement of Prilocaine- Induced Methemoglobinemia in regional anesthesia. Anesth Analg 2010. [Epub ahead of print].
Abstract
Methemoglobinemia is a disorder characterized by the presence of a higher than normal level of ferric (Fe+3) rarer man ferrous (Fe+2) hemoglobin. It may be in two forms, congenital or acquired methemoglobinemia. It is known that many agents can cause acquired methemoglobinemia. If the blood methemoglobin level reaches 55%, it can be lethal. Prompt care is needed in this situation. Here, a 4-month-old boy with acquired methemoglobinemia due to prilocaine use is presented. Methylene blue was used in the treatment of this case. The treatment enabled a dramatic improvement and was life saving
References
- DeBaun MR, Vichinsky E. Hereditary methemoglobinemia (Chapter 462, Hemoglobinopathies). In: Nelson Textbook of Pediatrics. 18th edition, Behrman & Kliegman& Jenson; 2007:2032-33.
- Trapp L, Will J. Acquired methemoglobinemia revisited. Dent Clin North Am 2010;54:665-75.
- Benini D, Vino L, Fanos V. Acquired methemoglobinemia: A case report. Pediatr Med Chir 1998;20:411-13.
- Türkiye Çocuk Hast Derg/Turkish J Pediatr Dis / 2013; 2: 86-88
- Frey B, Kehrer B. Toxic methaemoglobin concentrations in premature infants after application of a prilocaine containing cream and peridural prilocaine. Eur J Pediatr 1999;158:785-88.
- Akbayram S, Akgün C, Doğan M, Gündogdu M, Caksen H, Faik Öner A. Acquired methemoglobinemia due to application of prilocaine during circumcision. J Emerg Med 2010. [Epub ahead of print]
- Guay J. Methemoglobinemia related to local anesthetics: A summary of 242 episodes. Anesth Analg 2009;108:837-45.
- Soeding P, Deppe M, Gehring H. Pulse-Oximetric measurement of Prilocaine- Induced Methemoglobinemia in regional anesthesia. Anesth Analg 2010. [Epub ahead of print].
Details
| Other ID | JA99NE56SF |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | August 1, 2013 |
| Submission Date | August 1, 2013 |
| Published in Issue | Year 2013 Volume: 7 Issue: 2 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 6 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
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