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Konservatif Tedavi, Hemodiyaliz ve Sürekli Ayaktan Periton Diyalizi ile İzlenen Kronik Böbrek Yetmezlikli Çocuklarda Boy Gelişiminin Lineer Değerlendirilmesi

Year 2013, Volume: 7 Issue: 4, 178 - 182, 01.12.2013

Abstract

Amaç: Çalışmamızda, kronik böbrek yetmezliği (KBY) tanısı ile izlenen ve henüz böbrek transplantasyonu yapılmamış olan çocuklarda konservatif tedavi, sürekli ayaktan periton diyalizi (SAPD) ve hemodiyaliz tedavilerinin boy gelişimine etkilerinin belirlenmesi amaçlanmıştır.Gereç ve Yöntemler: Kronik böbrek yetmezliği tanısı ile enaz 6 aydır düzenli olarak izlenen, böbrek transplantasyonu yapılmamış ve büyüme hormonu tedavisi almamış toplam 87 hasta retrospektif olarak değerlendirilmiştir. Hastalar prediyaliz (n=25), SAPD (n=47) ve hemodiyaliz (n=15) grubu olarak 3 gruba ayrılmıştır. Hastaların antropometrik değerlendirmesinde boy, BoySDS ve ΔBoySDS parametreleri kullanılmıştır. Grupların antropometrik verileri longitudinal izlem başlangıcında, 1, 2 ve 3.yılda değerlendirilmiştir. Grupların desimal yaşları istatistiksel olarak anlamlı farklılık gösterdiğinden (p<0.01), gruplar arası karşılaştırma yaş faktörünü devre dışı bırakan ortalama BoySDS ve ΔBoySDS arasında yapılmıştır.Bulgular: Çalışma başlangıcında ortalama BoySDS değerlerinde, 1.yılda ve 3.yılda ortalama BoySDS ve ΔBoySDS değerlerinde gruplar arasında farklılık bulunmamıştır. İzlemin 2. yılında ise ortalama BoySDS ve ΔBoySDS değerlerinde prediyaliz ile SAPD grubu arasında istatistiksel olarak anlamlı farklılık olduğu ve bu parametrelerin prediyaliz grubunda anlamlı olarak yüksek olduğu belirlenmiştir (p<0.05 ve p<0.01).Sonuç: Kronik böbrek yetmezliği tanısı alan çocuklarda hayatın ilk yılında ya da takibeden yıllarda normal büyüme paternine ulaşma önemli bir sorundur. KBY’li bir çocuğa tatmin edici erişkin final boya ulaşma şansı tanımada gerekli koşul mümkün olan en erken dönemde transplantasyon programının başlatılması olacaktır.

References

  • Fine Rn. Etiology and treatment of growth retardation in children with chronic kidney disease and end-stage renal disease: A historical perspective. Pediatr nephrol 2010;25:725-32.
  • Janjua HS, Mahan JD. Growth in chronic kidney disease. Adv Chronic Kidney Dis 2011;18:324-31.
  • Issa n, lankireddy S, Kukla A. Should peritoneal dialysis be the preferred therapy pre-kidney transplantation? Adv Perit Dial 2012;28:89-93.
  • Stefanidis l, Klaus G. Growth of pre-pubertal children on dialysis. Pediatr nephrol 2007;22:1251-9.
  • Wesseling-Perry K, Salusky IB. Chronic kidney disease: Mineral and bone disorder in children. Semin nephrol 2013;33:169-79.
  • Mahan JD, Warady BA. Assessment and treatment of short stature in pediatric patients with chronic kidney disease: A consensus statement. Pediatr nephrol 2006; 21:917-30.
  • Kari JA, Gonzalez C, ledermann SE, Shaw V, Rees l. Outcome and growth of infants with severe chronic renal failure. Kidney Int 2000;57:1681-7.

The Evaluation of Longitudinal Growth in Pediatric Chronic Renal Failure Patients Receiving Conservative Treatment, Continuous Ambulatory Peritoneal Dialysis and Hemodialysis

Year 2013, Volume: 7 Issue: 4, 178 - 182, 01.12.2013

Abstract

Objective: The aim of the study was to determine the effects of conservative treatment, continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis on height growth in pediatric chronic renal insufficiency (CRI) patients who have not yet received renal replacement treatment. Material and Methods: This retrospective study included 87 pediatric CRI patients who were regularly followed for at least 6 months, and had not received growth hormone or renal replacement treatment. Patients were classified according to treatment modalities as predialysis (n=25), CAPD (n=47) and hemodialysis (n=15). Height, mean height standard deviation score (SDS) and mean Δ height SDS were used for anthropometric measurements. The data were evaluated at the beginning of the study and then at the first, second and third years of the longitudinal follow-up. As the decimal ages of the groups showed a statistically significant difference (p<0.01), comparison was conducted between the mean height SDS and Δ height SDS that deactivated the age factor. results: The mean height SDS and Δ height SDS did not differ between the groups in the first and third years. However, there was a statistically significant difference between predialysis and CAPD for the mean height SDS and Δ height SDS in the second year of the follow-up and these parameters were significantly higher in the predialysis group (p<0.05 and p<0.01). conclusion: Ensuring a normal growth pattern for pediatric CRI patients is an important problem. Early renal transplantation makes it possible for these children to attain a satisfying final adult height

References

  • Fine Rn. Etiology and treatment of growth retardation in children with chronic kidney disease and end-stage renal disease: A historical perspective. Pediatr nephrol 2010;25:725-32.
  • Janjua HS, Mahan JD. Growth in chronic kidney disease. Adv Chronic Kidney Dis 2011;18:324-31.
  • Issa n, lankireddy S, Kukla A. Should peritoneal dialysis be the preferred therapy pre-kidney transplantation? Adv Perit Dial 2012;28:89-93.
  • Stefanidis l, Klaus G. Growth of pre-pubertal children on dialysis. Pediatr nephrol 2007;22:1251-9.
  • Wesseling-Perry K, Salusky IB. Chronic kidney disease: Mineral and bone disorder in children. Semin nephrol 2013;33:169-79.
  • Mahan JD, Warady BA. Assessment and treatment of short stature in pediatric patients with chronic kidney disease: A consensus statement. Pediatr nephrol 2006; 21:917-30.
  • Kari JA, Gonzalez C, ledermann SE, Shaw V, Rees l. Outcome and growth of infants with severe chronic renal failure. Kidney Int 2000;57:1681-7.
There are 7 citations in total.

Details

Other ID JA72FG68KE
Journal Section Research Article
Authors

Zeynep Eras This is me

Mesiha Ekim This is me

Publication Date December 1, 2013
Submission Date December 1, 2013
Published in Issue Year 2013 Volume: 7 Issue: 4

Cite

Vancouver Eras Z, Ekim M. The Evaluation of Longitudinal Growth in Pediatric Chronic Renal Failure Patients Receiving Conservative Treatment, Continuous Ambulatory Peritoneal Dialysis and Hemodialysis. Turkish J Pediatr Dis. 2013;7(4):178-82.


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