BibTex RIS Cite

Nekrotizan Enterokolitte Önleyici Tedavi Seçenekleri

Year 2012, Volume: 6 Issue: 2, 121 - 128, 01.08.2012

Fatma Nur Sarı Uğur Dilmen

Abstract

Nekrotizan enterokolit, yenidoğanları etkileyen en ciddi gastrointestinal sistem hastalığıdır. Çok düşük doğum ağırlıklı bebeklerin %5-10’unda görülmektedir. Yenidoğan yoğun bakım ünitelerindeki mortalite ve morbiditenin en sık nedenlerinden biridir. Hastalığın patogenezi tam olarak bilinmemekle beraber, prematürite ve düşük doğum ağırlığı en önemli risk faktörleridir. Güncel tedavi şemaları ile nekrotizan enterokolitin olumsuz gidişatı değiştirilememektedir. Bununla birlikte antenatal ve postnatal dönemde birtakım önlemler alınabilmektedir. Prematüre doğumların ve fetal gelişme geriliğinin azaltılması nekrotizan enterokoliti önlemede önemli role sahiptir. Antenatal steroid kullanımı ve anne sütü ile beslenme nekrotizan enterokolitten korunmada etkili gözükmektedir. Oral antibiyotikler etkili gözükse de güvenilirlikleri kanıtlanmamıştır. Beslenmeye arginin eklenmesi ile yapılacak yeni çalışmalara ihtiyaç vardır. Prebiyotiklerin nekrotizan enterokolitten korunmadaki etkileri kesin değildir. Probiyotikler etkili bulunmakla birlikte doz, zamanlama, tür ve riskli bebeklerde kullanımıyla ilgili cevaplanması gereken sorular mevcuttur. Nekrotizan enterokolitten korunmada standart kılavuzların geliştirilmesine gerek vardır.

Keywords

Nekrotizan enterokolit önleyici tedaviler

References

  • Lin PW, Nasr TR, Stoll BJ. Necrotizing enterocolitis: recent scien- tific advances in pathophysiology and prevention. Semin Perinatol 2008;32(2):70-82.
  • Deshpande G, Rao S, Patole S. Probiotics for prevention of nec- rotising enterocolitis in preterm neonates with very low birthwe- ight: a systematic review of randomised controlled trials. Lancet 2007;369(9573):1614-20.
  • Embleton ND, Yates R. Probiotics and other preventative stra- tegies for necrotising enterocolitis. Semin Fetal Neonatal Med 2008;13(1):35-43.
  • Stoll BJ. Epidemiology of necrotizing enterocolitis. Clin Perinatol 1994;21(2):205-18.
  • Rowe MI, Reblock KK, Kurkchubasche AG, Healey PJ. Necroti- zing enterocolitis in the extremely low birth weight infant. J Pedi- atr Surg 1994;29(8):987-90.
  • Lin PW, Stoll BJ. Necrotising enterocolitis. Lancet 2006; 368(9543):1271-83.
  • Schulzke SM, Deshpande GC, Patole SK. Neurodevelopmental outcomes of very low-birth-weight infants with necrotizing ente- rocolitis: a systematic review of observational studies. Arch Pedi- atr Adolesc Med 2007;161(6):583-90.
  • Hsueh W, Caplan MS, Qu XW, Tan XD, De Plaen IG, Gonzalez- Crussi F. Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. Pediatr Dev Pathol 2003;6(1):6-23.
  • Dai D, Nanthkumar NN, Newburg DS, Walker WA. Role of oligo- saccharides and glycoconjugates in intestinal host defense. J Pedi- atr Gastroenterol Nutr 2000;30 Suppl 2: 23-33.
  • Costalos C, Kapiki A, Apostolou M, Papathoma E. The effect of a prebiotic supplemented formula on growth and stool microbiology of term infants. Early Hum Dev 2008;84(1):45-49.
  • Caplan M. Neonatal necrotizing enterocolitis. In: Martin RJ, Fana- roff AA, Walsh MC, eds. Fanaroff and Martin’s Neonatal-Perinatal Medicine. Philadelphia: Mosby 2006:1403-10.
  • Dorling J, Kempley S, Leaf A. Feeding growth restricted prematu- re infants with abnormal antenatal Doppler results. Arch Dis Child Fetal Neonatal Ed 2005;90(5):359-63.
  • Crowley P, Chalmers I, Keirse MJ. The effects of corticosteroid ad- ministration before premature delivery: an overview of the eviden- ce from controlled trials. Br J Obstet Gynaecol 1990;97(1):11-25.
  • Smith LM, Qureshi N, Chao CR. Effects of single and multiple co- urses of antenatal glucocorticoids in premature newborns less than 30 weeks’ gestation. J Maternal Fetal Med 2000;9(2):131-5.
  • Kenyon SL, Taylor DJ, Tarnow-Mordi W; ORALLE Collaborati- ve Group. Broad-spectrum antibiotics for preterm, prelabour rup- ture of fetal membranes: the ORACLE I randomised trial. ORAC- LE Collaborative Group. Lancet 2001; 357(9261):979-88.
  • Al-Sabbagh A, Moss S, Subhedar N. Neonatal necrotising entero- colitis and perinatal exposure to co-amoxyclav. Arch Dis Child Fe- tal Neonatal Ed 2004;89(2):187.
  • Treszl A, Heninger E, Kalman A, Schuler A, Tulassay T, Vásárhelyi B. Lower prevalence of IL-4 receptor alpha-chain gene G variant in very-low-birth-weight infants with necrotizing enterocolitis. J Pe- diatr Surg 2003;38(9):1374-8.
  • Schanler RJ, Lau C, Hurst NM, Smith EO. Randomized trial of do- nor human milk versus preterm formula as substitutes for mothers’ own milk in the feeding of extremely premature infants. Pediatrics 2005;116(2):400-6.
  • McGuire W, Anthony MY. Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review. Arch Dis Child Fetal Neonatal Ed 2003;88(1):11-4.
  • Quigley M, Henderson G, Anthony M, McGuine W. Formula milk versus donor breast milk for feeding preterm or low birth weight infants. Cochrane Database Syst Rev 2007; 4:CD002971.
  • Cooke RJ, Embleton ND. Feeding issues in premature infants. Arch Dis Child 2000;83(3):215-8.
  • Tyson JE, Kennedy KA. Trophic feedings for parenterally fed in- fants. Cochrane Database Syst Rev 2005; 20(39 :CD000504.
  • Berseth CL, Bisquera JA, Paje VU. Prolonging small feeding volu- mes early in life decreases the incidence of necrotizing enterocoli- tis in very low birth weight infants. Pediatrics 2003;111(3):529-34.
  • Kennedy KA, Tyson JE, Chamnanvanakij S. Rapid versus slow rate of advancement of feedings for promoting growth and preven- tin necrotizing enterocolitis in parenterally fed low-birth-weight infants. Cochrane Database Syst Rev 2000(2); CD001241.
  • Wu G, Jaeger LA, Bazer FW, Rhoads JM. Arginine deficiency in premature infants: biochemical mechanisms and nutritional impli- cations. J Nutr Biochem 2004;15(8):442-51.
  • Ziegler TR, Evans ME, Fernandez-Estivariz C, Jones DP. Trophic and cytoprotective nutrition for intestinal adaptation, mucosal re- pair, and barrier function. Annu Rev Nutr 2003;23:229-61.
  • Domeneghini C, Di Giancamillo A, Arrighi S, Bosi G. Gut-trophic feed additives and their effects upon the gut structure and intesti- nal metabolism. State of the art in the pig, and perspectives towards humans. Histol Histopathol 2006;21(3):273-83.
  • Zamora SA, Amin HJ, McMillan DD, Kubes P, Fick GH, Bütz- ner JD, Parsons HG, Scott RB. Plasma L-arginin concentrati- ons in premature infants with necrotizing enterocolitis. J Pediatr 1997;131(2):226-32.
  • Becker RM, Wu G, Galanko JA, Chen W, Maynor AR, Bose CL, Rhoads JM. Reduced serum amino acid concentrations in infants with necrotizing enterocolitis. J Pediatr 2000;137(6):785-93.
  • Schanler RJ. Probiotics and necrotising enterocolitis in premature infants. Arch Dis Child Fetal Neonatal Ed 2006;91(6):395-7.
  • Millar M, Wilks M, Costeloe K. Probiotics for premature infants? Arch Dis Child Fetal Neonatal Ed 2003;88(5):354-8.
  • Bin-Nun A, Bromiker R, Wilschanski M, Kaplan M, Rudensky B, Caplan M, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr 2005;147(2):192-6.
  • Hoyos AB. Reduced incidence of necrotizing enterocolitis associ- ated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit. Int J Infect Dis 1999;3(4):197-202.
  • Dani C, Biadaioli R, Bertini G, Martelli E, Rubaltelli FF. Probio- tics feeding in prevention of urinary tract infection, bacterial sep- sis and necrotizing enterocolitis in premature infants. A prospecti- ve double-blind study. Biol Neonate 2002;82(2): 103-8.
  • Kitajima H, Sumida Y, Tanaka R, Yuki N, Takayama H, Fujimura M. Early administration of Bifidobacterium breve to premature in- fants: randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 1997;76(2):F101-7.
  • Lin HC, Hsu CH, Chen HL, Chung MY, Hsu JF, Lien RI, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth we- ight premature infants: a multicenter, randomized, controlled trial. Pediatrics. 2008;122(4):693-700.
  • Kunz AN, Fairchok MP, Noel JM. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;116(2):517-8.
  • Kunz AN, Noel JM, Fairchok MP. Two cases of Lactobacillus bac- teremia during probiotic treatment of short gut syndrome. J Pediatr Gastroenterol Nutr 2004;38(4):457-8.
  • Thompson C, McCarter YS, Krause PJ, Herson VC. Lactobacillus acidophilus sepsis in a neonate. J Perinatol 2001;21(4):258-60.
  • Butel MJ, Suau A, Campeotto F, Magne F, Aires J, Ferraris L, et al. Conditions of bifidobacterial colonization in premature infants: a prospective analysis. J Pediatr Gastroenterol Nutr 2007;44(5):577- 82.
  • Moro G, Minoli I, Mosca M, Fanaro S, Jelinek J, Stahl B, Bo- ehm G. Dosage-related bifidogenic effects of galacto- and fructoo- ligosaccharides in formula-fed term infants. J Pediatr Gastroente- rol Nutr 2002;34(3):291-5.
  • Boehm G, Lidestri M, Casetta P, Jelinek J, Negretti F, Stahl B, et al. Supplementation of a bovine milk formula with an oligosaccha- ride mixture increases counts of faecal bifidobacteria in premature infants. Arch Dis Child Fetal Neonatal Ed 2002;86(3):178-81.
  • Lidestri M, Agosti M, Marini A, Boehm G. Oligosaccharides might stimulate calcium absorption in formula-fed premature infants. Acta Paediatr Suppl 2003;91(441):91-92.
  • Knol J, Scholtens P, Kafka C, Steenbakkers J, Gro S, Helm K, et al. Colon microflora in infants fed formula with galacto- and fructo- oligosaccharides: more like breast-fed infants. J Pediatr Gastroen- terol Nutr 2005;40(1):36-42.
  • Mihatsch WA, Hoegel J, Pohlandt F. Prebiotic oligosaccharides re- duce stool viscosity and accelerate gastrointestinal transport in pre- mature infants. Acta Paediatr 2006;95(7):843-8.
  • Riskin A, Hochwald O, Bader D, Srugo I, Naftali G, Kugelman A, et al. The effects of lactulose supplementation to enteral feedings in premature infants: a pilot study. J Pediatr 2010;156(2):209-14.
  • Ouwehand AC, Derrien M, de Vos W, Tiihonen K, Rautonen N. Prebiotics and other microbial substrates for gut functionality. Curr Opin Biotechnol 2005;16(2): 212-7.

PREVENTATIVE STRATEGIES IN NECROTIZING ENTEROCOLITIS

Year 2012, Volume: 6 Issue: 2, 121 - 128, 01.08.2012

Fatma Nur Sarı Uğur Dilmen

Abstract

Necrotizing enterocolitis (NEC) is the most serious disease of newborn gastrointestinal tract. NEC affects 5-10% of very low birth weight infants. It is one of the most common causes of mortality and morbidity in neonatal intensive care units. Although pathogenesis of the disease is not clear, prematurity and low birth weight are the most significant risk factors. Poor prognosis of NEC could not be changed with current therapies. However, some preventive strategies can be used in the antenatal and postnatal period. Decreasing the incidence of premature births or poor fetal growth would have a major effect on the prevalence of NEC. Breast feeding and antenatal steroid therapy seem to be preventive for NEC. Although oral antibiotics seem to be effective, their safety is unclear. New studies are required with arginin supplementation. Prebiotics do not appear to be of benefit in prevention of NEC. Although probiotics seem to be effective, optimum strain, duration of supplementation, dose and safety in critically ill infants are the questions that have to be answered. The development of standard guidelines is required in the prevention of NEC

Keywords

Necrotizing enterocolitis preventive strategies

References

  • Lin PW, Nasr TR, Stoll BJ. Necrotizing enterocolitis: recent scien- tific advances in pathophysiology and prevention. Semin Perinatol 2008;32(2):70-82.
  • Deshpande G, Rao S, Patole S. Probiotics for prevention of nec- rotising enterocolitis in preterm neonates with very low birthwe- ight: a systematic review of randomised controlled trials. Lancet 2007;369(9573):1614-20.
  • Embleton ND, Yates R. Probiotics and other preventative stra- tegies for necrotising enterocolitis. Semin Fetal Neonatal Med 2008;13(1):35-43.
  • Stoll BJ. Epidemiology of necrotizing enterocolitis. Clin Perinatol 1994;21(2):205-18.
  • Rowe MI, Reblock KK, Kurkchubasche AG, Healey PJ. Necroti- zing enterocolitis in the extremely low birth weight infant. J Pedi- atr Surg 1994;29(8):987-90.
  • Lin PW, Stoll BJ. Necrotising enterocolitis. Lancet 2006; 368(9543):1271-83.
  • Schulzke SM, Deshpande GC, Patole SK. Neurodevelopmental outcomes of very low-birth-weight infants with necrotizing ente- rocolitis: a systematic review of observational studies. Arch Pedi- atr Adolesc Med 2007;161(6):583-90.
  • Hsueh W, Caplan MS, Qu XW, Tan XD, De Plaen IG, Gonzalez- Crussi F. Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. Pediatr Dev Pathol 2003;6(1):6-23.
  • Dai D, Nanthkumar NN, Newburg DS, Walker WA. Role of oligo- saccharides and glycoconjugates in intestinal host defense. J Pedi- atr Gastroenterol Nutr 2000;30 Suppl 2: 23-33.
  • Costalos C, Kapiki A, Apostolou M, Papathoma E. The effect of a prebiotic supplemented formula on growth and stool microbiology of term infants. Early Hum Dev 2008;84(1):45-49.
  • Caplan M. Neonatal necrotizing enterocolitis. In: Martin RJ, Fana- roff AA, Walsh MC, eds. Fanaroff and Martin’s Neonatal-Perinatal Medicine. Philadelphia: Mosby 2006:1403-10.
  • Dorling J, Kempley S, Leaf A. Feeding growth restricted prematu- re infants with abnormal antenatal Doppler results. Arch Dis Child Fetal Neonatal Ed 2005;90(5):359-63.
  • Crowley P, Chalmers I, Keirse MJ. The effects of corticosteroid ad- ministration before premature delivery: an overview of the eviden- ce from controlled trials. Br J Obstet Gynaecol 1990;97(1):11-25.
  • Smith LM, Qureshi N, Chao CR. Effects of single and multiple co- urses of antenatal glucocorticoids in premature newborns less than 30 weeks’ gestation. J Maternal Fetal Med 2000;9(2):131-5.
  • Kenyon SL, Taylor DJ, Tarnow-Mordi W; ORALLE Collaborati- ve Group. Broad-spectrum antibiotics for preterm, prelabour rup- ture of fetal membranes: the ORACLE I randomised trial. ORAC- LE Collaborative Group. Lancet 2001; 357(9261):979-88.
  • Al-Sabbagh A, Moss S, Subhedar N. Neonatal necrotising entero- colitis and perinatal exposure to co-amoxyclav. Arch Dis Child Fe- tal Neonatal Ed 2004;89(2):187.
  • Treszl A, Heninger E, Kalman A, Schuler A, Tulassay T, Vásárhelyi B. Lower prevalence of IL-4 receptor alpha-chain gene G variant in very-low-birth-weight infants with necrotizing enterocolitis. J Pe- diatr Surg 2003;38(9):1374-8.
  • Schanler RJ, Lau C, Hurst NM, Smith EO. Randomized trial of do- nor human milk versus preterm formula as substitutes for mothers’ own milk in the feeding of extremely premature infants. Pediatrics 2005;116(2):400-6.
  • McGuire W, Anthony MY. Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review. Arch Dis Child Fetal Neonatal Ed 2003;88(1):11-4.
  • Quigley M, Henderson G, Anthony M, McGuine W. Formula milk versus donor breast milk for feeding preterm or low birth weight infants. Cochrane Database Syst Rev 2007; 4:CD002971.
  • Cooke RJ, Embleton ND. Feeding issues in premature infants. Arch Dis Child 2000;83(3):215-8.
  • Tyson JE, Kennedy KA. Trophic feedings for parenterally fed in- fants. Cochrane Database Syst Rev 2005; 20(39 :CD000504.
  • Berseth CL, Bisquera JA, Paje VU. Prolonging small feeding volu- mes early in life decreases the incidence of necrotizing enterocoli- tis in very low birth weight infants. Pediatrics 2003;111(3):529-34.
  • Kennedy KA, Tyson JE, Chamnanvanakij S. Rapid versus slow rate of advancement of feedings for promoting growth and preven- tin necrotizing enterocolitis in parenterally fed low-birth-weight infants. Cochrane Database Syst Rev 2000(2); CD001241.
  • Wu G, Jaeger LA, Bazer FW, Rhoads JM. Arginine deficiency in premature infants: biochemical mechanisms and nutritional impli- cations. J Nutr Biochem 2004;15(8):442-51.
  • Ziegler TR, Evans ME, Fernandez-Estivariz C, Jones DP. Trophic and cytoprotective nutrition for intestinal adaptation, mucosal re- pair, and barrier function. Annu Rev Nutr 2003;23:229-61.
  • Domeneghini C, Di Giancamillo A, Arrighi S, Bosi G. Gut-trophic feed additives and their effects upon the gut structure and intesti- nal metabolism. State of the art in the pig, and perspectives towards humans. Histol Histopathol 2006;21(3):273-83.
  • Zamora SA, Amin HJ, McMillan DD, Kubes P, Fick GH, Bütz- ner JD, Parsons HG, Scott RB. Plasma L-arginin concentrati- ons in premature infants with necrotizing enterocolitis. J Pediatr 1997;131(2):226-32.
  • Becker RM, Wu G, Galanko JA, Chen W, Maynor AR, Bose CL, Rhoads JM. Reduced serum amino acid concentrations in infants with necrotizing enterocolitis. J Pediatr 2000;137(6):785-93.
  • Schanler RJ. Probiotics and necrotising enterocolitis in premature infants. Arch Dis Child Fetal Neonatal Ed 2006;91(6):395-7.
  • Millar M, Wilks M, Costeloe K. Probiotics for premature infants? Arch Dis Child Fetal Neonatal Ed 2003;88(5):354-8.
  • Bin-Nun A, Bromiker R, Wilschanski M, Kaplan M, Rudensky B, Caplan M, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr 2005;147(2):192-6.
  • Hoyos AB. Reduced incidence of necrotizing enterocolitis associ- ated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit. Int J Infect Dis 1999;3(4):197-202.
  • Dani C, Biadaioli R, Bertini G, Martelli E, Rubaltelli FF. Probio- tics feeding in prevention of urinary tract infection, bacterial sep- sis and necrotizing enterocolitis in premature infants. A prospecti- ve double-blind study. Biol Neonate 2002;82(2): 103-8.
  • Kitajima H, Sumida Y, Tanaka R, Yuki N, Takayama H, Fujimura M. Early administration of Bifidobacterium breve to premature in- fants: randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 1997;76(2):F101-7.
  • Lin HC, Hsu CH, Chen HL, Chung MY, Hsu JF, Lien RI, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth we- ight premature infants: a multicenter, randomized, controlled trial. Pediatrics. 2008;122(4):693-700.
  • Kunz AN, Fairchok MP, Noel JM. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;116(2):517-8.
  • Kunz AN, Noel JM, Fairchok MP. Two cases of Lactobacillus bac- teremia during probiotic treatment of short gut syndrome. J Pediatr Gastroenterol Nutr 2004;38(4):457-8.
  • Thompson C, McCarter YS, Krause PJ, Herson VC. Lactobacillus acidophilus sepsis in a neonate. J Perinatol 2001;21(4):258-60.
  • Butel MJ, Suau A, Campeotto F, Magne F, Aires J, Ferraris L, et al. Conditions of bifidobacterial colonization in premature infants: a prospective analysis. J Pediatr Gastroenterol Nutr 2007;44(5):577- 82.
  • Moro G, Minoli I, Mosca M, Fanaro S, Jelinek J, Stahl B, Bo- ehm G. Dosage-related bifidogenic effects of galacto- and fructoo- ligosaccharides in formula-fed term infants. J Pediatr Gastroente- rol Nutr 2002;34(3):291-5.
  • Boehm G, Lidestri M, Casetta P, Jelinek J, Negretti F, Stahl B, et al. Supplementation of a bovine milk formula with an oligosaccha- ride mixture increases counts of faecal bifidobacteria in premature infants. Arch Dis Child Fetal Neonatal Ed 2002;86(3):178-81.
  • Lidestri M, Agosti M, Marini A, Boehm G. Oligosaccharides might stimulate calcium absorption in formula-fed premature infants. Acta Paediatr Suppl 2003;91(441):91-92.
  • Knol J, Scholtens P, Kafka C, Steenbakkers J, Gro S, Helm K, et al. Colon microflora in infants fed formula with galacto- and fructo- oligosaccharides: more like breast-fed infants. J Pediatr Gastroen- terol Nutr 2005;40(1):36-42.
  • Mihatsch WA, Hoegel J, Pohlandt F. Prebiotic oligosaccharides re- duce stool viscosity and accelerate gastrointestinal transport in pre- mature infants. Acta Paediatr 2006;95(7):843-8.
  • Riskin A, Hochwald O, Bader D, Srugo I, Naftali G, Kugelman A, et al. The effects of lactulose supplementation to enteral feedings in premature infants: a pilot study. J Pediatr 2010;156(2):209-14.
  • Ouwehand AC, Derrien M, de Vos W, Tiihonen K, Rautonen N. Prebiotics and other microbial substrates for gut functionality. Curr Opin Biotechnol 2005;16(2): 212-7.
There are 47 citations in total.

Details

Other ID JA57VM22DB
Journal Section Research Article
Authors

Fatma Nur Sarı This is me

Uğur Dilmen This is me

Publication Date August 1, 2012
Submission Date August 1, 2012
Published in Issue Year 2012 Volume: 6 Issue: 2

Cite

Vancouver Sarı FN, Dilmen U. PREVENTATIVE STRATEGIES IN NECROTIZING ENTEROCOLITIS. Türkiye Çocuk Hast Derg. 2012;6(2):121-8.


The publication language of Turkish Journal of Pediatric Disease is English.


Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.


The aim of the Turkish Journal of Pediatrics is to publish high-quality original research articles that will contribute to the international literature in the field of general pediatric health and diseases and its sub-branches. It also publishes editorial opinions, letters to the editor, reviews, case reports, book reviews, comments on previously published articles, meeting and conference proceedings, announcements, and biography. In addition to the field of child health and diseases, the journal also includes articles prepared in fields such as surgery, dentistry, public health, nutrition and dietetics, social services, human genetics, basic sciences, psychology, psychiatry, educational sciences, sociology and nursing, provided that they are related to this field. can be published.